C4B63_17g98

E3 ubiquitin-protein ligase UPL3
Trypanosoma cruzi Dm28c 2018 OG6: OG6_102181 OG7: OG7_0002947 176 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 176 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_56g51 ⚠
RNA-binding protein
— OG7
C4B63_13g157 ⚠
elongation factor 2
— OG7
C4B63_13g153 ⚠
elongation factor 2
— OG7
C4B63_160g33 ⚠
ubiquitin-activating enzyme E1
— OG7
C4B63_11g18 ⚠
translation elongation factor EF-2
— OG7
C4B63_11g17 ⚠
translation elongation factor EF-2
— OG7
C4B63_13g156 ⚠
elongation factor 2
— OG7
C4B63_9g523 ⚠
U5 small nuclear ribonucleoprotein component
— OG7
C4B63_13g155 ⚠
elongation factor 2
— OG7
C4B63_13g154 ⚠
elongation factor 2
— OG7
C4B63_48g28 ⚠
protein prenyltransferase
— OG7
C4B63_18g319 ⚠
Internalin-A
— OG7
C4B63_56g75 ⚠
Vacuolar protein sorting-associated protein V
— OG7
C4B63_243g12 ⚠
Vacuolar protein sorting-associated protein V
— OG7
C4B63_60g116 ⚠
aspartate carbamoyltransferase
— OG7
C4B63_31g264 ⚠
aspartate carbamoyltransferase
— OG7
C4B63_35g155 ⚠
aspartate carbamoyltransferase
— OG7
C4B63_134g60 ⚠
aspartate carbamoyltransferase
— OG7
C4B63_7g235 ⚠
Carboxypeptidase-like protein
— OG7
C4B63_40g50 ⚠
metallo-peptidase, Clan MC, Family M14
— OG7
C4B63_21g280 ⚠
ribonuclease mar1
— OG7
C4B63_113g49 ⚠
metallo-peptidase, Clan MC, Family M14
— OG7
C4B63_8g190 ⚠
conserved hypothetical protein
— OG7
C4B63_197g36 ⚠
conserved hypothetical protein
— OG7
C4B63_30g290 ⚠
mercaptopyruvate sulfurtransferase
— OG7
C4B63_18g217 ⚠
homoserine kinase
— OG7
C4B63_35g166 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_134g71 ⚠
conserved hypothetical protein
— OG7
C4B63_19g44 ⚠
5'-3' exoribonuclease 2
— OG7
C4B63_60g125 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_134g73 ⚠
conserved hypothetical protein
— OG7
C4B63_134g72 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_31g273 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_4g1058c ⚠
sporangia induced deflagellation-inducible pr
— OG7
C4B63_227g70c ⚠
sjogren s syndrome nuclear autoantigen 1
— OG7
C4B63_128g63 ⚠
GTP-binding protein
— OG7
C4B63_56g32 ⚠
GTPase
— OG7
C4B63_8g202 ⚠
GTP-binding protein
— OG7
C4B63_91g35 ⚠
GTPase
— OG7
C4B63_2g345 ⚠
GTP-binding protein
— OG7
C4B63_128g62 ⚠
50S ribosome-binding GTPase
— OG7
C4B63_128g61 ⚠
50S ribosome-binding GTPase
— OG7
C4B63_2g431 ⚠
GTPase protein
— OG7
C4B63_56g50 ⚠
Surp module,
— OG7
C4B63_2g816 ⚠
conserved hypothetical protein
— OG7
C4B63_2g761 ⚠
Peroxin 19
— OG7
C4B63_43g202 ⚠
hook complex protein, conserved
— OG7
C4B63_2g817 ⚠
conserved hypothetical protein
— OG7
C4B63_54g82 ⚠
conserved hypothetical protein
— OG7
C4B63_42g192 ⚠
N-alpha-acetyltransferase 25, NatB auxiliary
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.