C4B63_160g33

ubiquitin-activating enzyme E1
Trypanosoma cruzi Dm28c 2018 OG6: OG6_100444 OG7: OG7_0003530 200 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 200 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_7g391 ⚠
ubiquitin hydrolase
— Both
C4B63_26g231 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_2g4 ⚠
ubiquitin hydrolase
— OG7
C4B63_26g232 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_7g392 ⚠
ubiquitin hydrolase
— Both
C4B63_233g32 ⚠
ubiquitin hydrolase
— OG7
C4B63_233g31 ⚠
ubiquitin hydrolase
— OG7
C4B63_34g313 ⚠
casein kinase II, alpha chain
— OG6
C4B63_61g23 ⚠
tRNA-dihydrouridine synthase 3
— OG7
C4B63_18g319 ⚠
Internalin-A
— OG7
C4B63_14g171 ⚠
ubiquitin-protein ligase
— OG7
C4B63_113g49 ⚠
metallo-peptidase, Clan MC, Family M14
— OG7
C4B63_13g152 ⚠
elongation factor 2
— OG7
C4B63_199g21 ⚠
oxidoreductase
— OG7
C4B63_21g114 ⚠
oxidoreductase
— OG7
C4B63_20g226 ⚠
Probable importin subunit beta-4
— OG7
C4B63_113g58 ⚠
hydrogenase
— Both
C4B63_54g62 ⚠
proteasome activator protein pa26
— Both
C4B63_95g48 ⚠
protein kinase
— Both
C4B63_113g34 ⚠
ABC transporter
— Both
C4B63_11g26 ⚠
Xaa-Pro aminopeptidase
— Both
C4B63_49g130 ⚠
Putative hydrolase C777.06c
— Both
C4B63_49g131 ⚠
conserved hypothetical protein
— Both
C4B63_16g122 ⚠
Beta-lactamase superfamily domain containing
— Both
C4B63_102g71 ⚠
Programmed cell death protein 2, C-terminal d
— Both
C4B63_168g23 ⚠
Programmed cell death protein 2, C-terminal d
— Both
C4B63_42g242 ⚠
2-hydroxy-3-oxopropionate reductase
— Both
C4B63_2g416 ⚠
conserved hypothetical protein
— Both
C4B63_26g305 ⚠
conserved hypothetical protein
— Both
C4B63_56g67 ⚠
Sperm-tail PG-rich repeat-containing protein
— Both
C4B63_25g232 ⚠
Tetratricopeptide repeat protein 27 homolog
— Both
C4B63_267g8 ⚠
Structure-specific endonuclease subunit SLX1
— Both
C4B63_267g7 ⚠
GIY-YIG catalytic domain containing protein
— Both
C4B63_2g417 ⚠
conserved hypothetical protein
— Both
C4B63_12g310 ⚠
Structure-specific endonuclease subunit SLX1
— Both
C4B63_6g205 ⚠
Mitochondrial import receptor subunit ATOM69
— Both
C4B63_18g130 ⚠
glutamyl-tRNA synthetase
— Both
C4B63_212g12 ⚠
anion-transporting ATPase-like
— Both
C4B63_76g201c ⚠
conserved hypothetical protein
— OG6
C4B63_6g262 ⚠
MRP protein
— OG6
C4B63_35g171 ⚠
tRNA (guanine(37)-N1)-methyltransferase 1
— Both
C4B63_22g51 ⚠
conserved hypothetical protein
— Both
C4B63_7g410 ⚠
conserved hypothetical protein
— Both
C4B63_330g2 ⚠
MRP protein
— OG6
C4B63_8g526 ⚠
nucleotide-binding protein
— Both
C4B63_79g85 ⚠
nucleotide-binding protein
— Both
C4B63_2g72 ⚠
Importin 1
— Both
C4B63_52g42 ⚠
glutathione synthetase
— Both
C4B63_22g80 ⚠
tubulin-tyrosine ligase
— OG6
C4B63_35g166 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.