C4B63_52g42

glutathione synthetase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101596 OG7: OG7_0006266 89 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 89 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_10g165 ⚠
conserved hypothetical protein
— Both
C4B63_10g166 ⚠
conserved hypothetical protein
— Both
C4B63_160g33 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_19g259 ⚠
conserved hypothetical protein
— OG7
C4B63_95g32
conserved hypothetical protein
— OG7
C4B63_83g29 ⚠
ATP-dependent protease ATPase subunit HslU1
— OG7
C4B63_17g179 ⚠
Importin subunit beta-3
— OG7
C4B63_95g48
protein kinase
— Both
C4B63_61g105
Probable N6-adenine methyltransferase
— Both
C4B63_113g63
conserved hypothetical protein
— Both
C4B63_49g120
Acyl-CoA-binding domain-containing protein 4
— OG6
C4B63_2g1123c ⚠
small nuclear ribonucleoprotein Sm-F
— Both
C4B63_47g96 ⚠
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminoc
— OG7
C4B63_18g288 ⚠
heat shock 70 kDa protein, mitochondrial prec
— Both
C4B63_2g786 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_7g392 ⚠
ubiquitin hydrolase
— Both
C4B63_142g8 ⚠
methyltransferase
— Both
C4B63_136g37 ⚠
tRNA synthetases class II (A)/Threonyl and Al
— Both
C4B63_16g331 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_35g171 ⚠
tRNA (guanine(37)-N1)-methyltransferase 1
— Both
C4B63_54g62
proteasome activator protein pa26
— Both
C4B63_136g36 ⚠
Alanyl-tRNA editing protein Aarsd1
— Both
C4B63_101g36 ⚠
inositol-3-phosphate synthase
— Both
C4B63_7g391 ⚠
ubiquitin hydrolase
— Both
C4B63_47g107 ⚠
ABC transporter
— OG7
C4B63_11g283c ⚠
U6 snRNA-associated Sm-like protein LSm8
— OG7
C4B63_4g502 ⚠
ABC transporter
— OG7
C4B63_233g31 ⚠
ubiquitin hydrolase
— OG7
C4B63_233g32 ⚠
ubiquitin hydrolase
— OG7
C4B63_12g153 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_43g1065c ⚠
U6 snRNA-associated Sm-like protein LSm7p
— OG7
C4B63_70g129 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_271g80c ⚠
U6 snRNA-associated Sm-like protein LSm7p
— OG7
C4B63_193g9 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_69g174c ⚠
U6 snRNA-associated Sm-like protein LSm6p
— OG7
C4B63_13g189 ⚠
ubiquitin-like protein
— OG7
C4B63_144g102c ⚠
U6 snRNA-associated Sm-like protein LSm6p
— OG7
C4B63_16g95
conserved hypothetical protein
— OG7
C4B63_12g21 ⚠
Uncharacterized oxidoreductase YkwC
— OG7
C4B63_206g3 ⚠
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminoc
— OG7
C4B63_26g231 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_13g162 ⚠
cap guanine-N7 methyltransferase
— OG7
C4B63_2g4 ⚠
ubiquitin hydrolase
— OG7
C4B63_206g11 ⚠
ABC transporter
— OG7
C4B63_26g232 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_113g34 ⚠
ABC transporter
— Both
C4B63_333g14 ⚠
beta tubulin
— OG6
C4B63_85g40
conserved hypothetical protein
— Both
C4B63_45g133
splicing factor TSR1
— Both
C4B63_20g226 ⚠
Probable importin subunit beta-4
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.