C4B63_128g62

50S ribosome-binding GTPase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101986 OG7: OG7_0001608 280 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 280 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_206g3 ⚠
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminoc
— OG7
C4B63_32g259 ⚠
Cyclin-U4-1
— OG7
C4B63_293g2 ⚠
p22 protein precursor (Mitochondrial glycopro
— OG7
C4B63_2g567 ⚠
mRNA export factor MEX67
— OG7
C4B63_72g98 ⚠
RNA pseudouridylate synthase protein
— OG7
C4B63_13g1005c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_293g30c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_4g509 ⚠
FKBP-type peptidylprolyl cis-trans isomerase
— OG7
C4B63_18g174 ⚠
cyclin
— OG7
C4B63_56g69 ⚠
CYC2-like cyclin
— OG7
C4B63_7g382 ⚠
ubiquitin-protein ligase
— OG7
C4B63_4g63 ⚠
polyprenyl synthase
— OG7
C4B63_56g82 ⚠
mitochondrial glycoprotein-like protein
— OG7
C4B63_4g508 ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_276g11 ⚠
DIS3-like exonuclease(fragment)
— OG7
C4B63_19g179 ⚠
protein kinase
— OG7
C4B63_134g71 ⚠
conserved hypothetical protein
— OG7
C4B63_13g153 ⚠
elongation factor 2
— OG7
C4B63_13g157 ⚠
elongation factor 2
— OG7
C4B63_181g13 ⚠
conserved hypothetical protein
— OG7
C4B63_13g152 ⚠
elongation factor 2
— OG7
C4B63_20g49 ⚠
conserved hypothetical protein
— OG7
C4B63_171g30 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
C4B63_339g3 ⚠
tRNA-dihydrouridine synthase 3
— OG7
C4B63_243g9 ⚠
CYC2-like cyclin
— OG7
C4B63_49g54 ⚠
p22 protein precursor (Mitochondrial glycopro
— OG7
C4B63_114g1 ⚠
N-acetyltransferase
— OG7
C4B63_35g166 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_157g28 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
C4B63_17g98 ⚠
E3 ubiquitin-protein ligase UPL3
— OG7
C4B63_6g521 ⚠
DIS3-like exonuclease
— OG7
C4B63_72g106 ⚠
DIS3-like exonuclease(fragment)
— OG7
C4B63_34g156 ⚠
Acyl-CoA-binding domain-containing protein 4
— OG7
C4B63_61g23 ⚠
tRNA-dihydrouridine synthase 3
— OG7
C4B63_25g968c ⚠
Acyl-CoA-binding domain-containing protein 5
— OG7
C4B63_69g21 ⚠
pseudouridylate synthase-like protein
— OG7
C4B63_124g1 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_17g277 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_17g278 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_7g380 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_124g3 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_34g361 ⚠
phosphatidylinositol kinase related protein
— OG7
C4B63_124g2 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_22g113 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_38g68 ⚠
60S ribosomal protein L10
— Both
C4B63_10g492 ⚠
conserved hypothetical protein
— Both
C4B63_45g97 ⚠
eukaryotic translation initiation factor 3 su
— Both
C4B63_34g313 ⚠
casein kinase II, alpha chain
— OG6
C4B63_38g87 ⚠
60S ribosomal protein L10
— Both
C4B63_293g3 ⚠
conserved hypothetical protein
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.