C4B63_60g125

XRN 5'-3' exonuclease N-terminus
Trypanosoma cruzi Dm28c 2018 OG6: OG6_146609 OG7: OG7_0016759 96 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 96 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_2g88 ⚠
ubiquitin-protein ligase
— OG7
C4B63_127g35 ⚠
peptidase
— OG7
C4B63_294g18 ⚠
dihydrouridine synthase (Dus)
— OG7
C4B63_42g192 ⚠
N-alpha-acetyltransferase 25, NatB auxiliary
— OG7
C4B63_227g70c ⚠
sjogren s syndrome nuclear autoantigen 1
— OG7
C4B63_233g31 ⚠
ubiquitin hydrolase
— OG7
C4B63_233g32 ⚠
ubiquitin hydrolase
— OG7
C4B63_13g118 ⚠
tRNA-dihydrouridine synthase 2
— OG7
C4B63_20g51 ⚠
tRNA-dihydrouridine synthase 4
— OG7
C4B63_336g10 ⚠
dihydrouridine synthase (Dus)
— OG7
C4B63_293g2 ⚠
p22 protein precursor (Mitochondrial glycopro
— OG7
C4B63_313g3 ⚠
dihydrouridine synthase (Dus)(fragment)
— OG7
C4B63_10g137 ⚠
conserved hypothetical protein
— OG7
C4B63_7g382 ⚠
ubiquitin-protein ligase
— OG7
C4B63_7g392 ⚠
ubiquitin hydrolase
— OG7
C4B63_350g11 ⚠
dihydrouridine synthase (Dus)
— OG7
C4B63_23g100 ⚠
conserved hypothetical protein
— OG7
C4B63_42g70 ⚠
p22 protein precursor
— OG7
C4B63_56g82 ⚠
mitochondrial glycoprotein-like protein
— OG7
C4B63_322g8 ⚠
dihydrouridine synthase (Dus)
— OG7
C4B63_18g217 ⚠
homoserine kinase
— OG7
C4B63_20g61 ⚠
conserved hypothetical protein
— OG7
C4B63_339g3 ⚠
tRNA-dihydrouridine synthase 3
— OG7
C4B63_2g761 ⚠
Peroxin 19
— OG7
C4B63_25g215 ⚠
tRNA (cytosine(34)-C(5))-methyltransferase
— OG7
C4B63_113g58 ⚠
hydrogenase
— OG7
C4B63_8g510 ⚠
conserved hypothetical protein
— OG7
C4B63_22g79 ⚠
Tubulin/FtsZ family
— OG7
C4B63_79g85 ⚠
nucleotide-binding protein
— OG7
C4B63_8g526 ⚠
nucleotide-binding protein
— OG7
C4B63_87g16 ⚠
pitrilysin-like metalloprotease
— OG7
C4B63_87g17 ⚠
pitrilysin-like metalloprotease
— OG7
C4B63_11g93 ⚠
mitochondrial RNA binding complex 1 subunit
— OG7
C4B63_25g216 ⚠
conserved hypothetical protein
— OG7
C4B63_19g26 ⚠
guide RNA-binding protein of 21 kDa
— OG7
C4B63_81g44 ⚠
tRNA (cytosine(34)-C(5))-methyltransferase
— OG7
C4B63_49g54 ⚠
p22 protein precursor (Mitochondrial glycopro
— OG7
C4B63_4g245 ⚠
Multisite-specific tRNA:(cytosine-C(5))-methy
— OG7
C4B63_25g214 ⚠
conserved hypothetical protein
— OG7
C4B63_23g207 ⚠
tRNA (cytosine(34)-C(5))-methyltransferase
— OG7
C4B63_2g431 ⚠
GTPase protein
— OG7
C4B63_128g61 ⚠
50S ribosome-binding GTPase
— OG7
C4B63_128g62 ⚠
50S ribosome-binding GTPase
— OG7
C4B63_2g345 ⚠
GTP-binding protein
— OG7
C4B63_91g35 ⚠
GTPase
— OG7
C4B63_8g202 ⚠
GTP-binding protein
— OG7
C4B63_56g32 ⚠
GTPase
— OG7
C4B63_128g63 ⚠
GTP-binding protein
— OG7
C4B63_13g156 ⚠
elongation factor 2
— OG7
C4B63_134g60 ⚠
aspartate carbamoyltransferase
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.