C4B63_2g88

ubiquitin-protein ligase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_146796 OG7: OG7_0002947 176 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 176 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_2g1123c ⚠
small nuclear ribonucleoprotein Sm-F
— OG7
C4B63_18g277 ⚠
replication factor C, subunit 2
— OG7
C4B63_61g81 ⚠
conserved hypothetical protein
— OG7
C4B63_63g41 ⚠
replication factor C, subunit 3
— OG7
C4B63_39g340 ⚠
replication factor C, subunit 4
— OG7
C4B63_42g42 ⚠
co-chaperone GrpE
— OG7
C4B63_13g152 ⚠
elongation factor 2
— OG7
C4B63_13g157 ⚠
elongation factor 2
— OG7
C4B63_13g153 ⚠
elongation factor 2
— OG7
C4B63_13g156 ⚠
elongation factor 2
— OG7
C4B63_9g523 ⚠
U5 small nuclear ribonucleoprotein component
— OG7
C4B63_13g155 ⚠
elongation factor 2
— OG7
C4B63_13g154 ⚠
elongation factor 2
— OG7
C4B63_18g319 ⚠
Internalin-A
— OG7
C4B63_314g10 ⚠
5'-AMP-activated protein kinase subunit beta
— OG7
C4B63_16g11 ⚠
5'-AMP-activated protein kinase subunit beta
— OG7
C4B63_4g269 ⚠
conserved hypothetical protein
— OG7
C4B63_40g50 ⚠
metallo-peptidase, Clan MC, Family M14
— OG7
C4B63_113g49 ⚠
metallo-peptidase, Clan MC, Family M14
— OG7
C4B63_21g280 ⚠
ribonuclease mar1
— OG7
C4B63_8g190 ⚠
conserved hypothetical protein
— OG7
C4B63_197g36 ⚠
conserved hypothetical protein
— OG7
C4B63_35g166 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_134g71 ⚠
conserved hypothetical protein
— OG7
C4B63_60g125 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_134g73 ⚠
conserved hypothetical protein
— OG7
C4B63_134g72 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_31g273 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_56g32 ⚠
GTPase
— OG7
C4B63_8g202 ⚠
GTP-binding protein
— OG7
C4B63_91g35 ⚠
GTPase
— OG7
C4B63_2g345 ⚠
GTP-binding protein
— OG7
C4B63_2g431 ⚠
GTPase protein
— OG7
C4B63_76g32 ⚠
guide RNA associated protein, GAP2
— OG7
C4B63_56g50 ⚠
Surp module,
— OG7
C4B63_56g51 ⚠
RNA-binding protein
— OG7
C4B63_31g76 ⚠
ubiquitin-activating enzyme
— OG7
C4B63_42g593c ⚠
small nuclear ribonucleoprotein Sm-E
— OG7
C4B63_69g174c ⚠
U6 snRNA-associated Sm-like protein LSm6p
— OG7
C4B63_85g75 ⚠
ubiquitin activating enzyme
— OG7
C4B63_144g102c ⚠
U6 snRNA-associated Sm-like protein LSm6p
— OG7
C4B63_271g80c ⚠
U6 snRNA-associated Sm-like protein LSm7p
— OG7
C4B63_43g1065c ⚠
U6 snRNA-associated Sm-like protein LSm7p
— OG7
C4B63_11g283c ⚠
U6 snRNA-associated Sm-like protein LSm8
— OG7
C4B63_54g82 ⚠
conserved hypothetical protein
— OG7
C4B63_43g202 ⚠
hook complex protein, conserved
— OG7
C4B63_2g816 ⚠
conserved hypothetical protein
— OG7
C4B63_69g26 ⚠
endo-beta-N-acetylglucosaminidase
— OG7
C4B63_84g82 ⚠
DNA mismatch repair protein MSH2
— OG7
C4B63_2g768 ⚠
RNA-binding protein
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.