C4B63_102g53

conserved hypothetical protein
Trypanosoma cruzi Dm28c 2018 OG6: OG6_158058 OG7: OG7_0008375 126 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 126 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_8g54
conserved hypothetical protein
— Both
C4B63_2g354
isopentenyl-diphosphate delta-isomerase
— Both
C4B63_300g17 ⚠
E3 ubiquitin-protein ligase MGRN1
— OG6
C4B63_40g122
vacuolar protein sorting-associated protein-l
— Both
C4B63_4g258
prolyl-tRNA synthetase
— Both
C4B63_18g32 ⚠
pseudouridine synthase A-like protein
— Both
C4B63_12g211 ⚠
conserved hypothetical protein
— Both
C4B63_12g212 ⚠
conserved hypothetical protein
— Both
C4B63_31g99
WD repeat-containing protein 17
— Both
C4B63_12g208
leucine-rich repeat protein (LRRP)
— Both
C4B63_173g6 ⚠
Soluble NSF attachment protein, SNAP (parafla
— Both
C4B63_34g375 ⚠
Soluble NSF attachment protein, SNAP (parafla
— Both
C4B63_4g235 ⚠
5-oxoprolinase
— Both
C4B63_4g234 ⚠
5-oxoprolinase
— Both
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_8g540 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG7
C4B63_13g160 ⚠
6-phosphofructo-2-kinase/fructose-2,6-bisphos
— OG7
C4B63_4g514 ⚠
tRNA pseudouridine synthase A-like protein
— OG7
C4B63_8g527 ⚠
pseudouridylate synthase I
— OG7
C4B63_47g49 ⚠
tRNA pseudouridine synthase 1
— OG7
C4B63_85g75 ⚠
ubiquitin activating enzyme
— OG7
C4B63_57g94 ⚠
ATP-dependent RNA helicase
— OG7
C4B63_42g42
co-chaperone GrpE
— OG7
C4B63_359g9 ⚠
conserved hypothetical protein
— OG7
C4B63_271g10 ⚠
conserved hypothetical protein
— OG7
C4B63_102g61 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_14g171 ⚠
ubiquitin-protein ligase
— OG7
C4B63_61g81 ⚠
conserved hypothetical protein
— OG7
C4B63_2g815 ⚠
conserved hypothetical protein
— OG7
C4B63_488g7 ⚠
conserved hypothetical protein
— OG7
C4B63_63g41 ⚠
replication factor C, subunit 3
— OG7
C4B63_92g124 ⚠
conserved hypothetical protein
— OG7
C4B63_144g102c ⚠
U6 snRNA-associated Sm-like protein LSm6p
— OG7
C4B63_7g382 ⚠
ubiquitin-protein ligase
— OG7
C4B63_30g245
conserved hypothetical protein
— OG7
C4B63_44g232 ⚠
CRAL/TRIO domain containing protein
— OG7
C4B63_10g524 ⚠
nuclear transcription factor
— OG7
C4B63_2g1123c ⚠
small nuclear ribonucleoprotein Sm-F
— OG7
C4B63_6g517 ⚠
geranylgeranyl transferase type II beta subun
— OG7
C4B63_11g283c ⚠
U6 snRNA-associated Sm-like protein LSm8
— OG7
C4B63_359g23 ⚠
CRAL/TRIO domain containing protein
— OG7
C4B63_39g340 ⚠
replication factor C, subunit 4
— OG7
C4B63_24g301
phosphatidylinositol-4-phosphate 5-kinase
— OG7
C4B63_249g17 ⚠
conserved hypothetical protein
— OG7
C4B63_359g17 ⚠
conserved hypothetical protein
— OG7
C4B63_54g82
conserved hypothetical protein
— OG7
C4B63_197g36 ⚠
conserved hypothetical protein
— OG7
C4B63_8g190 ⚠
conserved hypothetical protein
— OG7
C4B63_2g88 ⚠
ubiquitin-protein ligase
— OG7
C4B63_7g388 ⚠
geranylgeranyl transferase type II beta subun
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.