C4B63_300g17

E3 ubiquitin-protein ligase MGRN1
Trypanosoma cruzi Dm28c 2018 OG6: OG6_144850 OG7: OG7_0001851 62 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 62 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_84g82 ⚠
DNA mismatch repair protein MSH2
— OG6
C4B63_173g6 ⚠
Soluble NSF attachment protein, SNAP (parafla
— OG6
C4B63_76g32 ⚠
guide RNA associated protein, GAP2
— OG6
C4B63_77g26 ⚠
conserved hypothetical protein
— OG6
C4B63_6g400 ⚠
conserved hypothetical protein
— OG6
C4B63_10g293 ⚠
Phosphatidylinositol 4-phosphate 5-kinase 6
— OG6
C4B63_157g32 ⚠
inosine-5'-monophosphate dehydrogenase
— OG6
C4B63_50g5 ⚠
protein farnesyltransferase
— OG6
C4B63_42g65 ⚠
ubiquitin-protein ligase
— OG6
C4B63_25g113 ⚠
GMP reductase
— OG6
C4B63_23g186 ⚠
aspartyl aminopeptidase
— OG6
C4B63_7g79 ⚠
aspartyl-tRNA synthetase
— OG6
C4B63_8g219 ⚠
protein farnesyltransferase
— OG6
C4B63_16g11 ⚠
5'-AMP-activated protein kinase subunit beta
— OG6
C4B63_271g80c ⚠
U6 snRNA-associated Sm-like protein LSm7p
— OG6
C4B63_70g129 ⚠
metallo-peptidase, Clan MF, Family M17
— OG6
C4B63_31g76 ⚠
ubiquitin-activating enzyme
— OG6
C4B63_260g15 ⚠
inosine-5'-monophosphate dehydrogenase
— OG6
C4B63_8g54 ⚠
conserved hypothetical protein
— OG6
C4B63_43g1065c ⚠
U6 snRNA-associated Sm-like protein LSm7p
— OG6
C4B63_12g153 ⚠
metallo-peptidase, Clan MF, Family M17
— OG6
C4B63_2g768 ⚠
RNA-binding protein
— OG6
C4B63_282g21 ⚠
conserved hypothetical protein
— OG6
C4B63_102g53 ⚠
conserved hypothetical protein
— OG6
C4B63_82g92 ⚠
conserved hypothetical protein
— OG6
C4B63_4g176 ⚠
Zn-finger in Ran binding protein and others/F
— OG6
C4B63_4g269 ⚠
conserved hypothetical protein
— OG6
C4B63_23g275 ⚠
ATP-dependent DEAD/H RNA helicase
— OG6
C4B63_117g55 ⚠
inosine-5'-monophosphate dehydrogenase
— OG6
C4B63_12g208 ⚠
leucine-rich repeat protein (LRRP)
— OG6
C4B63_44g234 ⚠
CRAL/TRIO domain containing protein
— OG6
C4B63_22g22 ⚠
ARM-like helical domain-containing protein
— OG6
C4B63_17g98 ⚠
E3 ubiquitin-protein ligase UPL3
— OG6
C4B63_23g201 ⚠
protein kinase
— OG6
C4B63_5g416 ⚠
conserved hypothetical protein
— OG6
C4B63_2g297 ⚠
conserved hypothetical protein
— OG6
C4B63_2g5 ⚠
casein kinase II
— OG6
C4B63_4g258 ⚠
prolyl-tRNA synthetase
— OG6
C4B63_314g10 ⚠
5'-AMP-activated protein kinase subunit beta
— OG6
C4B63_260g14 ⚠
inosine-5'-monophosphate dehydrogenase
— OG6
C4B63_4g234 ⚠
5-oxoprolinase
— OG6
C4B63_69g26 ⚠
endo-beta-N-acetylglucosaminidase
— OG6
C4B63_48g166 ⚠
serine/cysteine trypsin-like peptidase
— OG6
C4B63_18g50 ⚠
microtubule associated protein xmap215
— OG6
C4B63_12g212 ⚠
conserved hypothetical protein
— OG6
C4B63_34g107 ⚠
Nop14-like family
— OG6
C4B63_9g322 ⚠
translation initiation factor IF-2
— OG6
C4B63_42g187 ⚠
conserved hypothetical protein
— OG6
C4B63_142g11 ⚠
Protein shuttle craft
— OG6
C4B63_28g129 ⚠
replication factor C, subunit 1
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.