C4B63_260g15

inosine-5'-monophosphate dehydrogenase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_100534 OG7: OG7_0002926 120 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 120 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_17g52 ⚠
RNA-binding protein
— OG6
C4B63_8g249 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_62g90 ⚠
ribosome biogenesis protein
— OG6
C4B63_81g63 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_50g7 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_249g22 ⚠
dihydrolipoamide dehydrogenase
— Both
C4B63_8g221 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_60g78 ⚠
glutamine dependent carbamoyl-phosphate synth
— Both
C4B63_70g123 ⚠
3-methylcrotonoyl-CoA carboxylase beta subuni
— Both
C4B63_326g15 ⚠
dihydrolipoamide dehydrogenase
— Both
C4B63_26g353 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_60g75 ⚠
glutamine-dependent carbamoyl-phosphate synth
— Both
C4B63_57g67 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_150g38 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_15g11 ⚠
KRI1-like family/KRI1-like family C-terminal
— OG6
C4B63_60g77 ⚠
glutamine dependent carbamoyl-phosphate synth
— Both
C4B63_10g280 ⚠
dihydrolipoamide dehydrogenase
— Both
C4B63_3g1088 ⚠
conserved hypothetical protein
— OG6
C4B63_75g42 ⚠
rRNA processing protein
— OG6
C4B63_42g179 ⚠
ribosome biogenesis regulatory protein (RRS1)
— OG6
C4B63_99g108 ⚠
conserved hypothetical protein
— OG6
C4B63_18g232 ⚠
glyceraldehyde 3-phosphate dehydrogenase
— OG6
C4B63_23g249 ⚠
peter pan protein
— OG6
C4B63_12g208 ⚠
leucine-rich repeat protein (LRRP)
— Both
C4B63_173g6 ⚠
Soluble NSF attachment protein, SNAP (parafla
— Both
C4B63_34g375 ⚠
Soluble NSF attachment protein, SNAP (parafla
— Both
C4B63_4g235 ⚠
5-oxoprolinase
— Both
C4B63_4g234 ⚠
5-oxoprolinase
— Both
C4B63_19g268 ⚠
conserved hypothetical protein
— OG6
C4B63_17g54 ⚠
RNA-binding protein
— OG6
C4B63_168g16 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_57g94 ⚠
ATP-dependent RNA helicase
— OG7
C4B63_326g16 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_249g23 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_358g1 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_1g63 ⚠
SKP1
— OG7
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_44g232 ⚠
CRAL/TRIO domain containing protein
— OG7
C4B63_10g524 ⚠
nuclear transcription factor
— OG7
C4B63_6g517 ⚠
geranylgeranyl transferase type II beta subun
— OG7
C4B63_359g23 ⚠
CRAL/TRIO domain containing protein
— OG7
C4B63_24g301 ⚠
phosphatidylinositol-4-phosphate 5-kinase
— OG7
C4B63_249g17 ⚠
conserved hypothetical protein
— OG7
C4B63_359g17 ⚠
conserved hypothetical protein
— OG7
C4B63_249g12 ⚠
conserved hypothetical protein
— OG7
C4B63_102g61 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_488g7 ⚠
conserved hypothetical protein
— OG7
C4B63_2g815 ⚠
conserved hypothetical protein
— OG7
C4B63_9g383 ⚠
conserved hypothetical protein
— OG7
C4B63_1g61 ⚠
conserved hypothetical protein
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.