C4B63_168g16

aspartyl-tRNA synthetase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100778 OG7: OG7_0002299 395 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 395 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_41g128 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_342110.1 OG7 Tb927.4.2310 ↔ Tb927.6.950	OG7
C4B63_224g16 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_342110.1 OG7 Tb927.4.2310 ↔ Tb927.6.950	OG7
C4B63_41g119 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_342110.1 OG7 Tb927.4.2310 ↔ Tb927.6.950	OG7
C4B63_41g122 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_342110.1 OG7 Tb927.4.2310 ↔ Tb927.6.950	OG7
C4B63_41g125 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_342110.1 OG7 Tb927.4.2310 ↔ Tb927.6.950	OG7
C4B63_2g450 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
C4B63_31g99 ⚠ WD repeat-containing protein 17	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_342110.1	OG7
C4B63_12g153 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
C4B63_70g129 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
C4B63_14g97 ⚠ isoleucyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
C4B63_425g4 ⚠ tyrosyl or methionyl-tRNA synthetase	—	OG6 TCSYLVIO_001244 ↔ TCSYLVIO_003107 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_003107 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_010624 OG7 Tb927.4.2310 ↔ Tb927.8.5330	Both
C4B63_76g56 ⚠ Aminoacyl tRNA synthase complex-interacting m	—	OG6 TCSYLVIO_001244 ↔ TCSYLVIO_003107 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_003107 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_010624 OG7 Tb927.4.2310 ↔ Tb927.8.5330	Both
C4B63_55g95 ⚠ tyrosyl or methionyl-tRNA synthetase	—	OG6 TCSYLVIO_001244 ↔ TCSYLVIO_003107 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_003107 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_010624 OG7 Tb927.4.2310 ↔ Tb927.8.5330	Both
C4B63_193g9 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
C4B63_28g25 ⚠ pyruvate dehydrogenase (lipoamide) kinase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
C4B63_52g161 ⚠ tyrosyl-tRNA synthetase	—	OG7 TCSYLVIO_001244 ↔ TCSYLVIO_003107 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_010624 OG7 Tb927.4.2310 ↔ Tb927.8.5330	OG7
C4B63_23g248 ⚠ inorganic pyrophosphatase	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
C4B63_32g238 ⚠ tubulin folding cofactor D	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003107 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003107	Both
C4B63_32g239 ⚠ tubulin folding cofactor D	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003107 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003107	Both
C4B63_63g95 ⚠ poly(A)-specific ribonuclease PARN	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003867 OG7 LdBPK_230660.1 ↔ LdBPK_342110.1	OG7
C4B63_4g258 ⚠ prolyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
C4B63_16g30 ⚠ poly(A)-specific ribonuclease PARN	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003867 OG7 LdBPK_230660.1 ↔ LdBPK_342110.1	OG7
C4B63_2g75 ⚠ poly(A)-specific ribonuclease PARN(fragment)	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003867 OG7 LdBPK_230660.1 ↔ LdBPK_342110.1	OG7
C4B63_2g74 ⚠ poly(A)-specific ribonuclease PARN(fragment)	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003867 OG7 LdBPK_230660.1 ↔ LdBPK_342110.1	OG7
C4B63_160g6 ⚠ poly(A)-specific ribonuclease PARN	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003867 OG7 LdBPK_230660.1 ↔ LdBPK_342110.1	OG7
C4B63_42g187 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_003867 OG7 LdBPK_300580.1 ↔ LdBPK_342110.1	OG7
C4B63_70g77 ⚠ acidocalcisomal pyrophosphatase	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
C4B63_22g11 ⚠ developmentally regulated phosphoprotein	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
C4B63_2g566 ⚠ phenylalanyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_342110.1	OG7
C4B63_7g377 ⚠ [Pyruvate dehydrogenase (acetyl-transferring)	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
C4B63_14g96 ⚠ isoleucil-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
C4B63_3g1104 ⚠ threonyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007511 OG7 Tb927.4.2310 ↔ Tb927.5.1090	OG7
C4B63_339g3 ⚠ tRNA-dihydrouridine synthase 3	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_009102	OG7
C4B63_25g215 ⚠ tRNA (cytosine(34)-C(5))-methyltransferase	—	OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004998 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004998	OG7
C4B63_26g245 ⚠ inositol/phosphatidylinositol phosphatase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007569	OG7
C4B63_61g23 ⚠ tRNA-dihydrouridine synthase 3	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_009102	OG7
C4B63_13g161 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_009932	OG7
C4B63_2g243 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_005710	OG7
C4B63_47g107 ⚠ ABC transporter	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_006012	OG7
C4B63_25g120 ⚠ Protein kinase domain	—	OG7 TCSYLVIO_003107 ↔ TCSYLVIO_009362	OG7
C4B63_128g59 ⚠ dihydrolipoamide branched chain transacylase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_009880	OG7
C4B63_42g216 ⚠ disgorgin	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004663	OG7
C4B63_23g110 ⚠ UDP-glucose:glycoprotein glucosyltransferase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004363	OG7
C4B63_14g103 ⚠ beta adaptin	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004597	OG7
C4B63_63g32 ⚠ adaptin-related protein-like	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004597	OG7
C4B63_22g116 ⚠ Pre-mRNA-splicing factor 38	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007337	OG7
C4B63_52g128 ⚠ protein kinase	—	OG7 TCSYLVIO_003107 ↔ TCSYLVIO_009362	OG7
C4B63_17g69 ⚠ phenylalanyl-tRNA synthetase alpha chain	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004213	OG7
C4B63_153g40 ⚠ inositol 5-phosphatase 1	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007569	OG7
C4B63_2g203 ⚠ synaptojanin (N-terminal domain)	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007569	OG7

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