C4B63_14g96

isoleucil-tRNA synthetase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100811 OG7: OG7_0003029 237 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 237 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_193g9 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
C4B63_70g129 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
C4B63_12g153 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
C4B63_425g4 ⚠ tyrosyl or methionyl-tRNA synthetase	—	OG6 Tb927.10.9190 ↔ Tb927.8.5330 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 +1 more	Both
C4B63_2g450 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005560 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
C4B63_76g56 ⚠ Aminoacyl tRNA synthase complex-interacting m	—	OG6 Tb927.10.9190 ↔ Tb927.8.5330 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 +1 more	Both
C4B63_55g95 ⚠ tyrosyl or methionyl-tRNA synthetase	—	OG6 Tb927.10.9190 ↔ Tb927.8.5330 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 +1 more	Both
C4B63_7g79 ⚠ aspartyl-tRNA synthetase	—	OG6 Tb927.10.9190 ↔ Tb927.4.2310 OG6 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 +1 more	Both
C4B63_46g91 ⚠ leucyl-tRNA synthetase	—	OG6 Tb927.10.9190 ↔ Tb927.11.3730 OG6 TCSYLVIO_003028 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.11.3730 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_004705	Both
C4B63_52g161 ⚠ tyrosyl-tRNA synthetase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 OG7 Tb927.10.9190 ↔ Tb927.8.5330	Both
C4B63_168g16 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
C4B63_42g203 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
C4B63_42g202 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
C4B63_102g61 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
C4B63_93g64 ⚠ amidohydrolase	—	OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
C4B63_93g65 ⚠ amidohydrolase	—	OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
C4B63_348g23 ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
C4B63_294g17 ⚠ dihydrouridine synthase (Dus)	—	OG7 TCSYLVIO_004705 ↔ TCSYLVIO_009102	OG7
C4B63_25g1526c ⚠ Acyl-lipid (8-3)-desaturase	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
C4B63_10g403 ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
C4B63_8g211 ⚠ cytochrome b	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
C4B63_1g121c ⚠ cytochrome b5-like protein	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
C4B63_70g572c ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
C4B63_34g372 ⚠ cytochrome b-domain protein	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
C4B63_17g179 ⚠ Importin subunit beta-3	—	OG7 LdBPK_070810.1 ↔ LdBPK_365870.1	OG7
C4B63_72g106 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004705	OG7
C4B63_276g11 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004705	OG7
C4B63_30g129 ⚠ rrp44p homologue	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004705	OG7
C4B63_19g113 ⚠ Translation machinery-associated protein 22	—	OG6 LdBPK_250420.1 ↔ LdBPK_365870.1 OG7 LdBPK_250420.1 ↔ LdBPK_365870.1	Both
C4B63_42g42 ⚠ co-chaperone GrpE	—	OG6 TCSYLVIO_003139 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003139 ↔ TCSYLVIO_004705	Both
C4B63_70g77 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004705	Both
C4B63_23g248 ⚠ inorganic pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004705	Both
C4B63_54g22 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005080 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005080	Both
C4B63_4g213 ⚠ cyclophilin type peptidyl-prolyl cis-trans is	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006217	OG6
C4B63_4g214 ⚠ cyclophilin type peptidyl-prolyl cis-trans is	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006217	OG6
C4B63_10g517 ⚠ tryptophanyl-tRNA synthetase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010724	OG6
C4B63_40g52 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008197 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008197	Both
C4B63_4g375 ⚠ glucan 1,3-alpha-glucosidase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006141	Both
C4B63_147g74 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005180 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005180	Both
C4B63_21g251 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010937 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010937	Both
C4B63_124g7 ⚠ Pre-mRNA-splicing factor 38	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007337 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007337	Both
C4B63_25g329 ⚠ Nuclear migration protein nudC	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010327	Both
C4B63_147g73 ⚠ U3 snoRNP-associated protein-like YAOH	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005180 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005180	Both
C4B63_24g267 ⚠ U3 snoRNP-associated protein-like YAOH	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005180 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005180	Both
C4B63_19g137 ⚠ cleavage and polyadenylation specificity fact	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005414	Both
C4B63_227g2 ⚠ glucan 1,3-alpha-glucosidase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006141	Both
C4B63_23g207 ⚠ tRNA (cytosine(34)-C(5))-methyltransferase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_004998 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_004998	Both
C4B63_2g510 ⚠ arginyl-tRNA synthetase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005509 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005509	Both
C4B63_192g24 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_004910 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_004910	Both
C4B63_19g179 ⚠ protein kinase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007401	Both

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