C4B63_19g113

Translation machinery-associated protein 22
Trypanosoma cruzi Dm28c 2018 OG6: OG6_102629 OG7: OG7_0007574 81 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 81 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_7g392 ⚠
ubiquitin hydrolase
— Both
C4B63_95g32
conserved hypothetical protein
— OG7
C4B63_13g162 ⚠
cap guanine-N7 methyltransferase
— OG7
C4B63_16g95
conserved hypothetical protein
— OG7
C4B63_17g179 ⚠
Importin subunit beta-3
— OG7
C4B63_40g52
conserved hypothetical protein
— Both
C4B63_2g1123c ⚠
small nuclear ribonucleoprotein Sm-F
— Both
C4B63_10g517 ⚠
tryptophanyl-tRNA synthetase
— OG6
C4B63_82g71 ⚠
tryptophanyl-tRNA synthetase
— OG6
C4B63_18g288 ⚠
heat shock 70 kDa protein, mitochondrial prec
— Both
C4B63_12g28
RNA-binding protein
— OG6
C4B63_26g232 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_54g62
proteasome activator protein pa26
— Both
C4B63_429g2 ⚠
leucine-rich repeat-containing protein
— Both
C4B63_2g66
helicase
— OG6
C4B63_9g247
small nuclear ribonucleoprotein protein
— Both
C4B63_7g391 ⚠
ubiquitin hydrolase
— Both
C4B63_113g34 ⚠
ABC transporter
— Both
C4B63_20g12
Vacuolar protein sorting-associated protein 2
— Both
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
C4B63_9g416 ⚠
ATP-dependent Clp protease subunit, heat shoc
— Both
C4B63_4g508 ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_11g283c ⚠
U6 snRNA-associated Sm-like protein LSm8
— OG7
C4B63_4g502 ⚠
ABC transporter
— OG7
C4B63_233g31 ⚠
ubiquitin hydrolase
— OG7
C4B63_233g32 ⚠
ubiquitin hydrolase
— OG7
C4B63_13g1005c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_293g30c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_4g509 ⚠
FKBP-type peptidylprolyl cis-trans isomerase
— OG7
C4B63_43g1065c ⚠
U6 snRNA-associated Sm-like protein LSm7p
— OG7
C4B63_271g80c ⚠
U6 snRNA-associated Sm-like protein LSm7p
— OG7
C4B63_9g471 ⚠
ATP-dependent protease binding subunit(fragme
— Both
C4B63_171g30 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
C4B63_69g174c ⚠
U6 snRNA-associated Sm-like protein LSm6p
— OG7
C4B63_157g28 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
C4B63_47g107 ⚠
ABC transporter
— OG7
C4B63_144g102c ⚠
U6 snRNA-associated Sm-like protein LSm6p
— OG7
C4B63_26g231 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_49g325c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_2g4 ⚠
ubiquitin hydrolase
— OG7
C4B63_206g11 ⚠
ABC transporter
— OG7
C4B63_142g8 ⚠
methyltransferase
— Both
C4B63_12g237
eukaryotic release factor 3
— OG6
C4B63_355g19 ⚠
inositol-3-phosphate synthase(fragment)
— Both
C4B63_101g36 ⚠
inositol-3-phosphate synthase
— Both
C4B63_25g322
U3 small nucleolar RNA-associated protein 25
— Both
C4B63_52g42
glutathione synthetase
— Both
C4B63_46g49
conserved hypothetical protein
— Both
C4B63_76g201c
conserved hypothetical protein
— OG6
C4B63_26g266
E1-like ubiquitin-activating enzyme
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.