C4B63_26g266

E1-like ubiquitin-activating enzyme
Trypanosoma cruzi Dm28c 2018 OG6: OG6_104369 OG7: OG7_0002775 37 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 37 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_83g29 ⚠
ATP-dependent protease ATPase subunit HslU1
— Both
C4B63_82g71 ⚠
tryptophanyl-tRNA synthetase
— OG6
C4B63_10g517 ⚠
tryptophanyl-tRNA synthetase
— OG6
C4B63_40g52
conserved hypothetical protein
— Both
C4B63_122g20 ⚠
ribonucleoside-diphosphate reductase small ch
— Both
C4B63_76g201c
conserved hypothetical protein
— OG6
C4B63_25g322
U3 small nucleolar RNA-associated protein 25
— Both
C4B63_12g237
eukaryotic release factor 3
— OG6
C4B63_173g6 ⚠
Soluble NSF attachment protein, SNAP (parafla
— Both
C4B63_34g375 ⚠
Soluble NSF attachment protein, SNAP (parafla
— Both
C4B63_27g3 ⚠
ribonucleoside-diphosphate reductase small ch
— Both
C4B63_38g40
Reticulocyte-binding protein 2 homolog a
— Both
C4B63_49g325c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_157g28 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
C4B63_171g30 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
C4B63_4g508 ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_4g509 ⚠
FKBP-type peptidylprolyl cis-trans isomerase
— OG7
C4B63_293g30c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_13g1005c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_19g113
Translation machinery-associated protein 22
— Both
C4B63_136g36 ⚠
Alanyl-tRNA editing protein Aarsd1
— Both
C4B63_136g37 ⚠
tRNA synthetases class II (A)/Threonyl and Al
— Both
C4B63_12g220 ⚠
pyruvate phosphate dikinase
— Both
C4B63_12g221 ⚠
pyruvate phosphate dikinase
— Both
C4B63_193g9 ⚠
metallo-peptidase, Clan MF, Family M17
— +1 more Both
C4B63_70g129 ⚠
metallo-peptidase, Clan MF, Family M17
— +1 more Both
C4B63_12g153 ⚠
metallo-peptidase, Clan MF, Family M17
— +1 more Both
C4B63_27g180 ⚠
ATP-dependent protease ATPase subunit HslU2
— Both
C4B63_26g317 ⚠
Alanyl-tRNA editing protein Aarsd1-B
— Both
C4B63_23g85 ⚠
leucine-rich repeat-containing protein
— Both
C4B63_101g21
conserved hypothetical protein
— Both
C4B63_20g12
Vacuolar protein sorting-associated protein 2
— Both
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
C4B63_9g247
small nuclear ribonucleoprotein protein
— Both
C4B63_2g66
helicase
— OG6
C4B63_429g2 ⚠
leucine-rich repeat-containing protein
— Both
C4B63_12g28
RNA-binding protein
— OG6
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.