C4B63_122g20

ribonucleoside-diphosphate reductase small chain
Trypanosoma cruzi Dm28c 2018 OG6: OG6_100537 OG7: OG7_0003661 93 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 93 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_40g52 ⚠
conserved hypothetical protein
— Both
C4B63_157g28 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
C4B63_21g245 ⚠
ATP-dependent DEAD/H RNA helicase
— OG7
C4B63_49g325c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_271g10 ⚠
conserved hypothetical protein
— OG7
C4B63_17g50 ⚠
Outer row dynein-assembly protein 7
— OG7
C4B63_22g77 ⚠
conserved hypothetical protein
— Both
C4B63_63g46 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— Both
C4B63_83g29 ⚠
ATP-dependent protease ATPase subunit HslU1
— Both
C4B63_93g64 ⚠
amidohydrolase
— Both
C4B63_93g65 ⚠
amidohydrolase
— Both
C4B63_2g176 ⚠
elongation factor 1-alpha
— OG6
C4B63_2g782 ⚠
ATP-dependent RNA helicase
— OG7
C4B63_10g517 ⚠
tryptophanyl-tRNA synthetase
— OG6
C4B63_8g58 ⚠
Dynein assembly factor 1, axonemal homolog
— Both
C4B63_82g71 ⚠
tryptophanyl-tRNA synthetase
— OG6
C4B63_8g191 ⚠
JmjC domain-containing protein E
— Both
C4B63_6g384 ⚠
DEAD-box ATP-dependent RNA helicase, mitochon
— Both
C4B63_12g28 ⚠
RNA-binding protein
— OG6
C4B63_75g57 ⚠
U3 small nucleolar RNA-associated protein 6
— Both
C4B63_197g37 ⚠
JmjC domain-containing protein E
— Both
C4B63_429g2 ⚠
leucine-rich repeat-containing protein
— Both
C4B63_2g66 ⚠
helicase
— OG6
C4B63_9g247 ⚠
small nuclear ribonucleoprotein protein
— Both
C4B63_293g30c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_11g491 ⚠
trypanothione synthetase
— OG7
C4B63_16g7 ⚠
trypanothione synthetase
— OG7
C4B63_26g206 ⚠
glutaminyl-tRNA synthetase
— OG7
C4B63_106g2 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_9g333 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_9g335 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_106g1 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_314g6 ⚠
trypanothione synthetase
— OG7
C4B63_63g81 ⚠
protein transport protein Sec23A
— OG7
C4B63_45g221 ⚠
ATP-dependent DEAD/H RNA helicase
— OG7
C4B63_13g1005c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
C4B63_4g509 ⚠
FKBP-type peptidylprolyl cis-trans isomerase
— OG7
C4B63_207g22 ⚠
ATP-dependent RNA helicase HEL67
— OG7
C4B63_4g508 ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_31g58 ⚠
ATP-dependent DEAD/H RNA helicase
— OG7
C4B63_4g90 ⚠
ATP-dependent RNA helicase HEL67
— OG7
C4B63_81g40 ⚠
ATP-dependent DEAD/H RNA helicase
— OG7
C4B63_43g202 ⚠
hook complex protein, conserved
— OG7
C4B63_94g58 ⚠
ATP-dependent DEAD/H RNA helicase
— OG7
C4B63_171g30 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
C4B63_40g163 ⚠
leucine-rich repeat protein (LRRP)
— OG7
C4B63_12g153 ⚠
metallo-peptidase, Clan MF, Family M17
— +1 more Both
C4B63_38g147 ⚠
spermidine synthase
— Both
C4B63_38g167 ⚠
spermidine synthase
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.