C4B63_19g137

cleavage and polyadenylation specificity factor

Trypanosoma cruzi Dm28c 2018 OG6: OG6_103283 OG7: OG7_0002417 201 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 201 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_7g306 ⚠ cleavage and polyadenylation specificity fact	—	OG6 Tb927.11.230 ↔ Tb927.4.1340 OG6 LdBPK_250170.1 ↔ LdBPK_343210.1 OG7 Tb927.11.230 ↔ Tb927.4.1340 OG7 LdBPK_250170.1 ↔ LdBPK_343210.1	Both
C4B63_322g8 ⚠ dihydrouridine synthase (Dus)	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_009102	OG7
C4B63_76g56 ⚠ Aminoacyl tRNA synthase complex-interacting m	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_010624	OG7
C4B63_425g4 ⚠ tyrosyl or methionyl-tRNA synthetase	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_010624	OG7
C4B63_47g107 ⚠ ABC transporter	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006012	OG7
C4B63_34g372 ⚠ cytochrome b-domain protein	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_005414	OG7
C4B63_294g17 ⚠ dihydrouridine synthase (Dus)	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_009102	OG7
C4B63_113g34 ⚠ ABC transporter	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006012	OG7
C4B63_206g11 ⚠ ABC transporter	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006012	OG7
C4B63_72g106 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005414	OG7
C4B63_276g11 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005414	OG7
C4B63_30g129 ⚠ rrp44p homologue	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005414	OG7
C4B63_1g57 ⚠ AAA ATPase	—	OG6 LdBPK_091280.1 ↔ LdBPK_250170.1 OG7 LdBPK_091280.1 ↔ LdBPK_250170.1	Both
C4B63_70g77 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005414	Both
C4B63_23g248 ⚠ inorganic pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005414	Both
C4B63_14g96 ⚠ isoleucil-tRNA synthetase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005414	Both
C4B63_28g123 ⚠ conserved hypothetical protein	—	OG6 LdBPK_240950.1 ↔ LdBPK_250170.1 OG7 LdBPK_240950.1 ↔ LdBPK_250170.1	Both
C4B63_14g97 ⚠ isoleucyl-tRNA synthetase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005414	Both
C4B63_28g122 ⚠ conserved hypothetical protein	—	OG6 LdBPK_240950.1 ↔ LdBPK_250170.1 OG7 LdBPK_240950.1 ↔ LdBPK_250170.1	Both
C4B63_56g85 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_005414	Both
C4B63_56g84 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_005414	Both
C4B63_34g118 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_005414	Both
C4B63_109g37 ⚠ Gar1/Naf1 RNA binding region containing prote	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_005414	Both
C4B63_41g200 ⚠ Anaphase-promoting complex subunit 8	—	OG6 LdBPK_120560.1 ↔ LdBPK_250170.1 OG7 LdBPK_050410.1 ↔ LdBPK_250170.1 OG7 LdBPK_120560.1 ↔ LdBPK_250170.1	Both
C4B63_6g521 ⚠ DIS3-like exonuclease	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_005414 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005414	Both
C4B63_49g166 ⚠ alanyl-tRNA synthetase	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_005414	Both
C4B63_61g23 ⚠ tRNA-dihydrouridine synthase 3	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_009102	Both
C4B63_22g116 ⚠ Pre-mRNA-splicing factor 38	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_007337 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007337	Both
C4B63_58g37 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_006877 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006877	Both
C4B63_355g19 ⚠ inositol-3-phosphate synthase(fragment)	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007453	Both
C4B63_19g179 ⚠ protein kinase	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007401	Both
C4B63_2g244 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_005710 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_005710	Both
C4B63_21g251 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_010937 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_010937	Both
C4B63_2g823 ⚠ acyl-CoA dehydrogenase	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_005872 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_005872	Both
C4B63_227g2 ⚠ glucan 1,3-alpha-glucosidase	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_005414 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006141	Both
C4B63_25g329 ⚠ Nuclear migration protein nudC	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_010327	Both
C4B63_52g161 ⚠ tyrosyl-tRNA synthetase	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_010624	Both
C4B63_101g36 ⚠ inositol-3-phosphate synthase	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007453	Both
C4B63_124g7 ⚠ Pre-mRNA-splicing factor 38	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_007337 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007337	Both
C4B63_244g4 ⚠ Nuclear migration protein nudC	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_010327	Both
C4B63_49g164 ⚠ alanyl-tRNA synthetase	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_005414	Both
C4B63_4g213 ⚠ cyclophilin type peptidyl-prolyl cis-trans is	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_006217	OG6
C4B63_4g214 ⚠ cyclophilin type peptidyl-prolyl cis-trans is	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_006217	OG6
C4B63_10g517 ⚠ tryptophanyl-tRNA synthetase	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_010724	OG6
C4B63_4g375 ⚠ glucan 1,3-alpha-glucosidase	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_005414 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006141	Both
C4B63_101g15 ⚠ serine peptidase, Clan SC, Family S9B	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_007536 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007536	Both
C4B63_13g161 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_009932 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_009932	Both
C4B63_19g195 ⚠ Nuclear pore complex protein 158	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_007387 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007387	Both
C4B63_49g165 ⚠ alanyl-tRNA synthetase	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_005414	Both
C4B63_82g71 ⚠ tryptophanyl-tRNA synthetase	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_010724	OG6

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