C4B63_41g200

Anaphase-promoting complex subunit 8
Trypanosoma cruzi Dm28c 2018 OG6: OG6_102790 OG7: OG7_0003813 130 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 130 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_14g250 ⚠
Anaphase-promoting complex subunit 3
— Both
C4B63_4g525 ⚠
anaphase promoting complex, subunit 10-like p
— +2 more Both
C4B63_163g31 ⚠
conserved hypothetical protein
— +1 more Both
C4B63_42g168 ⚠
CDC16
— +2 more Both
C4B63_28g122 ⚠
conserved hypothetical protein
— +2 more Both
C4B63_30g273 ⚠
conserved hypothetical protein
— +1 more Both
C4B63_28g123 ⚠
conserved hypothetical protein
— +2 more Both
C4B63_18g71 ⚠
cyclosome subunit
— +2 more Both
C4B63_18g72 ⚠
cyclosome subunit
— +2 more Both
C4B63_278g6 ⚠
endosomal trafficking protein RME-8
— Both
C4B63_31g1443c ⚠
RING-box protein 1
— OG7
C4B63_43g141 ⚠
conserved hypothetical protein
— Both
C4B63_63g98
ubiquitin-protein ligase
— OG6
C4B63_10g105 ⚠
kinesin protein
— OG6
C4B63_49g186 ⚠
ccr4-not transcription complex subunit
— Both
C4B63_48g156 ⚠
conserved hypothetical protein
— OG6
C4B63_4g480 ⚠
Flagellum attachment zone protein 7(fragment)
— OG6
C4B63_48g155 ⚠
conserved hypothetical protein
— OG6
C4B63_127g30 ⚠
Flagellum attachment zone protein 14
— Both
C4B63_13g243 ⚠
intraflagellar transport protein 122B(fragmen
— Both
C4B63_86g55 ⚠
Probable E3 ubiquitin-protein ligase HERC3
— OG6
C4B63_42g174 ⚠
conserved hypothetical protein
— Both
C4B63_186g7 ⚠
cleavage and polyadenylation specificity fact
— Both
C4B63_18g325 ⚠
endosomal trafficking protein RME-8
— Both
C4B63_124g1 ⚠
phosphatidylinositol 3-kinase
— Both
C4B63_35g116 ⚠
VPS13A C
— OG6
C4B63_1g57 ⚠
AAA ATPase
— Both
C4B63_33g8 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— OG7
C4B63_29g3 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— OG7
C4B63_56g104 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— OG7
C4B63_81g15 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_7g56 ⚠
Protein transport protein sec71
— OG7
C4B63_81g14 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_7g55 ⚠
conserved hypothetical protein
— OG7
C4B63_7g57 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_7g67 ⚠
Sec7 guanine-nucleotide exchange factor
— OG7
C4B63_7g68 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_22g288 ⚠
Midasin
— OG7
C4B63_42g199 ⚠
conserved hypothetical protein
— OG7
C4B63_46g32 ⚠
E3 ubiquitin-protein ligase HERC2
— OG7
C4B63_61g104 ⚠
conserved hypothetical protein
— OG7
C4B63_55g168 ⚠
Cilia- and flagella-associated protein 57
— OG7
C4B63_17g278 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_7g236 ⚠
regulatory subunit of protein kinase a-like p
— OG7
C4B63_31g46 ⚠
structural maintenance of chromosome 3 protei
— OG7
C4B63_351g1 ⚠
conserved hypothetical protein
— OG7
C4B63_2g729 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
C4B63_31g221 ⚠
RING-box protein 1A
— OG7
C4B63_20g154 ⚠
Flagellar Member 7
— OG7
C4B63_10g132 ⚠
conserved hypothetical protein
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.