C4B63_63g98

ubiquitin-protein ligase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_109174 OG7: OG7_0000785 93 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 93 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_124g3 ⚠
phosphatidylinositol 3-kinase
— OG6
C4B63_278g6 ⚠
endosomal trafficking protein RME-8
— OG6
C4B63_4g103
intraflagellar transport protein 140
— OG6
C4B63_42g254
conserved hypothetical protein
— OG6
C4B63_10g105 ⚠
kinesin protein
— OG6
C4B63_10g106 ⚠
kinesin
— OG6
C4B63_11g50
General negative regulator of transcription s
— OG6
C4B63_4g480 ⚠
Flagellum attachment zone protein 7(fragment)
— OG6
C4B63_4g481 ⚠
Flagellum attachment zone protein 7
— OG6
C4B63_49g186
ccr4-not transcription complex subunit
— OG6
C4B63_124g1 ⚠
phosphatidylinositol 3-kinase
— OG6
C4B63_22g113 ⚠
phosphatidylinositol 3-kinase
— OG6
C4B63_18g325 ⚠
endosomal trafficking protein RME-8
— OG6
C4B63_124g2 ⚠
phosphatidylinositol 3-kinase
— OG6
C4B63_79g36 ⚠
CCR4-NOT transcription complex subunit 1
— OG6
C4B63_86g69 ⚠
mucin TcMUCII
— OG6
C4B63_17g276
TRAF3-interacting protein 1
— OG6
C4B63_128g60
zinc-finger protein family member
— OG6
C4B63_34g361
phosphatidylinositol kinase related protein
— OG6
C4B63_23g242
radial spoke protein RSP10
— OG6
C4B63_186g7 ⚠
cleavage and polyadenylation specificity fact
— OG6
C4B63_17g128 ⚠
cleavage and polyadenylation specificity fact
— OG6
C4B63_84g21 ⚠
conserved hypothetical protein
— OG6
C4B63_84g22 ⚠
conserved hypothetical protein
— OG6
C4B63_293g22 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG6
C4B63_127g30
Flagellum attachment zone protein 14
— OG6
C4B63_63g101 ⚠
Phosphatidylinositol 3-kinase tor1
— OG6
C4B63_7g424 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG6
C4B63_76g43
proteasome regulatory ATPase subunit 1
— OG6
C4B63_1g57
AAA ATPase
— OG6
C4B63_42g168
CDC16
— OG6
C4B63_42g174
conserved hypothetical protein
— OG6
C4B63_49g160 ⚠
ATP-dependent DEAD/H RNA helicase
— OG6
C4B63_293g23 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG6
C4B63_293g24 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG6
C4B63_293g21 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG6
C4B63_38g152 ⚠
tetratricopeptide repeat protein (TPR)
— OG6
C4B63_89g42
translation initiation factor EIF-2b alpha su
— OG6
C4B63_41g200
Anaphase-promoting complex subunit 8
— OG6
C4B63_163g31 ⚠
conserved hypothetical protein
— OG6
C4B63_30g273 ⚠
conserved hypothetical protein
— OG6
C4B63_2g156 ⚠
protein kinase A catalytic subunit 3
— OG6
C4B63_4g242 ⚠
protein kinase A catalytic subunit 3
— OG6
C4B63_24g196 ⚠
microtubule-associated protein
— OG6
C4B63_24g194 ⚠
microtubule-associated protein
— OG6
C4B63_24g195 ⚠
microtubule-associated protein
— OG6
C4B63_52g40
immunodominant antigen
— OG6
C4B63_51g179
conserved hypothetical protein
— OG6
C4B63_6g572 ⚠
5'-3' exoribonuclease A
— OG6
C4B63_4g506
Microtubule Associated kinase (CAP-Gly domain
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.