C4B63_4g506

Microtubule Associated kinase (CAP-Gly domain)
Trypanosoma cruzi Dm28c 2018 OG6: OG6_145814 OG7: OG7_0002326 142 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 142 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_124g3 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_1g57 ⚠
AAA ATPase
— Both
C4B63_281g8 ⚠
translation initiation factor eIF2B delta sub
— OG7
C4B63_21g61 ⚠
guanine nucleotide exchange factor subunit GC
— OG7
C4B63_19g15 ⚠
translation initiation factor eIF2B delta sub
— OG7
C4B63_220g12 ⚠
peroxidoxin
— OG7
C4B63_295g16 ⚠
tryparedoxin peroxidase
— OG7
C4B63_295g18 ⚠
tryparedoxin peroxidase
— OG7
C4B63_295g22 ⚠
tryparedoxin peroxidase
— OG7
C4B63_26g257 ⚠
tryparedoxin peroxidase
— OG7
C4B63_26g255 ⚠
tryparedoxin peroxidase
— OG7
C4B63_149g19 ⚠
peroxidoxin
— OG7
C4B63_43g161 ⚠
ATP-dependent RNA helicase SUB2
— OG7
C4B63_54g24 ⚠
ATP-dependent DEAD/H RNA helicase
— OG7
C4B63_85g83 ⚠
Eukaryotic initiation factor 4A-1
— OG7
C4B63_26g253 ⚠
tryparedoxin peroxidase
— OG7
C4B63_6g161 ⚠
Eukaryotic initiation factor 4A-1
— OG7
C4B63_295g20 ⚠
tryparedoxin peroxidase
— OG7
C4B63_81g15 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_7g56 ⚠
Protein transport protein sec71
— OG7
C4B63_81g14 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_7g55 ⚠
conserved hypothetical protein
— OG7
C4B63_7g57 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_7g67 ⚠
Sec7 guanine-nucleotide exchange factor
— OG7
C4B63_7g68 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_9g333 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_106g2 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_314g6 ⚠
trypanothione synthetase
— OG7
C4B63_106g1 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_9g335 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_9g263 ⚠
trypanothione synthetase
— OG7
C4B63_16g7 ⚠
trypanothione synthetase
— OG7
C4B63_11g491 ⚠
trypanothione synthetase
— OG7
C4B63_34g285 ⚠
imidazolonepropionase
— OG7
C4B63_22g113 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_124g2 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_128g64 ⚠
oligopeptidase b(fragment)
— OG7
C4B63_46g32 ⚠
E3 ubiquitin-protein ligase HERC2
— OG7
C4B63_10g132 ⚠
conserved hypothetical protein
— OG7
C4B63_40g159 ⚠
translation initiation factor 2 subunit
— OG7
C4B63_275g17 ⚠
UPF0160 protein C27H6.8
— OG7
C4B63_122g4 ⚠
UPF0160 protein C27H6.8
— OG7
C4B63_12g196 ⚠
conserved hypothetical protein
— OG7
C4B63_128g65 ⚠
prolyl oligopeptidase
— OG7
C4B63_63g37 ⚠
oligopeptidase b(fragment)
— OG7
C4B63_80g15 ⚠
cAMP response protein 1
— OG7
C4B63_25g220 ⚠
5'-3' exoribonuclease B
— OG7
C4B63_51g192 ⚠
protein kinase A regulatory subunit
— OG7
C4B63_128g66 ⚠
oligopeptidase b(fragment)
— OG7
C4B63_7g236 ⚠
regulatory subunit of protein kinase a-like p
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.