C4B63_6g161

Eukaryotic initiation factor 4A-1
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101114 OG7: OG7_0000130 53 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 53 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_51g115 ⚠
Proliferation-associated protein 2G4
— OG7
C4B63_7g313 ⚠
amidinotransferase
— OG7
C4B63_51g109 ⚠
conserved hypothetical protein
— OG7
C4B63_4g360 ⚠
UDP-galactopyranose mutase
— OG7
C4B63_23g122 ⚠
serine/threonine protein kinase
— OG7
C4B63_40g25 ⚠
Biotin--acetyl-CoA-carboxylase ligase
— OG7
C4B63_13g231 ⚠
serine/threonine protein kinase
— OG7
C4B63_76g131 ⚠
protein kinase
— OG7
C4B63_54g35 ⚠
protein kinase
— OG7
C4B63_6g391 ⚠
protein kinase
— OG7
C4B63_51g107 ⚠
conserved hypothetical protein
— OG7
C4B63_13g41 ⚠
protein kinase
— OG7
C4B63_20g213 ⚠
enoyl-CoA hydratase/isomerase family protein
— OG7
C4B63_12g295 ⚠
GTP-binding nuclear protein rtb2
— OG7
C4B63_45g139 ⚠
serine/threonine protein kinase
— OG7
C4B63_4g68 ⚠
metallo-peptidase, Clan MG, Family M24
— OG7
C4B63_14g183 ⚠
mitochondrial intermediate peptidase
— OG7
C4B63_37g366 ⚠
thimet oligopeptidase
— OG7
C4B63_62g82 ⚠
thimet oligopeptidase
— OG7
C4B63_47g34 ⚠
mitochondrial malate dehydrogenase
— OG7
C4B63_4g486 ⚠
glycosomal malate dehydrogenase
— OG7
C4B63_2g443 ⚠
UDP-N-acetylglucosamine pyrophosphorylase
— OG7
C4B63_63g53 ⚠
conserved hypothetical protein
— OG7
C4B63_47g33 ⚠
malate dehydrogenase
— OG7
C4B63_10g491 ⚠
conserved hypothetical protein
— OG7
C4B63_44g171 ⚠
serine/threonine protein kinase
— OG7
C4B63_49g176 ⚠
serine/threonine protein phosphatase
— OG7
C4B63_30g261 ⚠
deoxyribose-phosphate aldolase
— OG7
C4B63_295g22 ⚠
tryparedoxin peroxidase
— Both
C4B63_26g257 ⚠
tryparedoxin peroxidase
— Both
C4B63_26g255 ⚠
tryparedoxin peroxidase
— Both
C4B63_149g19 ⚠
peroxidoxin
— Both
C4B63_26g253 ⚠
tryparedoxin peroxidase
— Both
C4B63_220g12 ⚠
peroxidoxin
— Both
C4B63_295g16 ⚠
tryparedoxin peroxidase
— Both
C4B63_295g18 ⚠
tryparedoxin peroxidase
— Both
C4B63_295g20 ⚠
tryparedoxin peroxidase
— Both
C4B63_4g331 ⚠
tubulin-specific chaperone
— Both
C4B63_4g506 ⚠
Microtubule Associated kinase (CAP-Gly domain
— OG7
C4B63_42g47 ⚠
Protein DJ-1 homolog B
— OG7
C4B63_18g168 ⚠
mago nashi-like protein
— Both
C4B63_163g21 ⚠
deoxyribose-phosphate aldolase
— OG7
C4B63_32g225 ⚠
3-hydroxy-3-methylglutaryl-CoA synthase
— OG7
C4B63_38g167 ⚠
spermidine synthase
— OG7
C4B63_38g147 ⚠
spermidine synthase
— OG7
C4B63_183g15 ⚠
spermidine synthase
— OG7
C4B63_87g38 ⚠
protein phosphatase 2A, regulatory subunit B
— OG7
C4B63_20g212 ⚠
enoyl-CoA hydratase/isomerase family protein
— OG7
C4B63_242g2 ⚠
protein kinase
— OG7
C4B63_4g359 ⚠
UDP-galactopyranose mutase
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.