C4B63_4g486

glycosomal malate dehydrogenase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_133291 OG7: OG7_0004751 67 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 67 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_38g147 ⚠
spermidine synthase
— OG7
C4B63_183g15 ⚠
spermidine synthase
— OG7
C4B63_38g167 ⚠
spermidine synthase
— OG7
C4B63_128g65 ⚠
prolyl oligopeptidase
— OG7
C4B63_6g564 ⚠
oligopeptidase B-like protein
— OG7
C4B63_93g64 ⚠
amidohydrolase
— OG7
C4B63_128g64 ⚠
oligopeptidase b(fragment)
— OG7
C4B63_19g178 ⚠
Sodium/hydrogen exchanger 9B2
— OG7
C4B63_63g37 ⚠
oligopeptidase b(fragment)
— OG7
C4B63_303g16 ⚠
trypanothione reductase
— OG7
C4B63_63g36 ⚠
prolyl endopeptidase
— OG7
C4B63_25g226 ⚠
sodium/hydrogen exchanger
— OG7
C4B63_14g241 ⚠
trypanothione reductase
— OG7
C4B63_93g65 ⚠
amidohydrolase
— OG7
C4B63_62g82 ⚠
thimet oligopeptidase
— OG7
C4B63_37g366 ⚠
thimet oligopeptidase
— OG7
C4B63_14g183 ⚠
mitochondrial intermediate peptidase
— OG7
C4B63_4g68 ⚠
metallo-peptidase, Clan MG, Family M24
— OG7
C4B63_51g115 ⚠
Proliferation-associated protein 2G4
— OG7
C4B63_7g212 ⚠
ruvB-like DNA helicase
— OG7
C4B63_122g16 ⚠
oligopeptidase b
— OG7
C4B63_128g66 ⚠
oligopeptidase b(fragment)
— OG7
C4B63_25g227 ⚠
sodium/hydrogen exchanger(fragment)
— OG7
C4B63_43g161 ⚠
ATP-dependent RNA helicase SUB2
— OG7
C4B63_2g443 ⚠
UDP-N-acetylglucosamine pyrophosphorylase
— OG7
C4B63_54g24 ⚠
ATP-dependent DEAD/H RNA helicase
— OG7
C4B63_85g83 ⚠
Eukaryotic initiation factor 4A-1
— OG7
C4B63_6g161 ⚠
Eukaryotic initiation factor 4A-1
— OG7
C4B63_44g171 ⚠
serine/threonine protein kinase
— OG7
C4B63_49g176 ⚠
serine/threonine protein phosphatase
— OG7
C4B63_63g53 ⚠
conserved hypothetical protein
— OG7
C4B63_56g64 ⚠
Present in the outer mitochondrial membrane p
— OG7
C4B63_42g67 ⚠
Protein F37C4.5
— OG7
C4B63_243g4 ⚠
Present in the outer mitochondrial membrane p
— OG7
C4B63_10g491 ⚠
conserved hypothetical protein
— OG7
C4B63_9g333 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_314g6 ⚠
trypanothione synthetase
— OG7
C4B63_23g234 ⚠
inosine-adenosine-guanosine-nucleosidehydrola
— OG7
C4B63_8g559 ⚠
Adenine phosphoribosyltransferase
— OG7
C4B63_42g103 ⚠
pyridoxal kinase
— OG7
C4B63_106g1 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_9g335 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_9g494 ⚠
cytochrome-b5 reductase
— OG7
C4B63_9g263 ⚠
trypanothione synthetase
— OG7
C4B63_69g74 ⚠
cytochrome c oxidase subunit V
— OG7
C4B63_46g107 ⚠
NADH-cytochrome b5 reductase
— OG7
C4B63_133g46 ⚠
cytosolic malate dehydrogenase
— OG7
C4B63_57g98 ⚠
succinyl-CoA ligase
— OG7
C4B63_8g560 ⚠
Adenine phosphoribosyltransferase
— OG7
C4B63_63g46 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.