C4B63_32g225

3-hydroxy-3-methylglutaryl-CoA synthase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101064 OG7: OG7_0006553 106 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 106 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_85g83 ⚠
Eukaryotic initiation factor 4A-1
— OG7
C4B63_187g34 ⚠
protein kinase
— Both
C4B63_32g322 ⚠
protein kinase
— Both
C4B63_80g21
Nucleoside diphosphate kinase
— Both
C4B63_21g76
Adenosine deaminase-like protein
— Both
C4B63_16g302 ⚠
3-ketoacyl-CoA thiolase
— Both
C4B63_220g12 ⚠
peroxidoxin
— Both
C4B63_295g16 ⚠
tryparedoxin peroxidase
— Both
C4B63_295g18 ⚠
tryparedoxin peroxidase
— Both
C4B63_295g22 ⚠
tryparedoxin peroxidase
— Both
C4B63_26g257 ⚠
tryparedoxin peroxidase
— Both
C4B63_26g255 ⚠
tryparedoxin peroxidase
— Both
C4B63_149g19 ⚠
peroxidoxin
— Both
C4B63_26g253 ⚠
tryparedoxin peroxidase
— Both
C4B63_295g20 ⚠
tryparedoxin peroxidase
— Both
C4B63_23g130 ⚠
Fumarate hydratase class I, cytosolic
— Both
C4B63_28g60 ⚠
fumarate hydratase
— Both
C4B63_22g59
cytidine triphosphate synthase
— Both
C4B63_87g24 ⚠
nonspecific lipid-transfer protein
— OG7
C4B63_18g280 ⚠
conserved hypothetical protein
— OG7
C4B63_46g74 ⚠
aminopeptidase
— OG7
C4B63_41g246 ⚠
puromycin-sensitive aminopeptidase-like prote
— OG7
C4B63_41g245 ⚠
puromycin-sensitive aminopeptidase-like prote
— OG7
C4B63_170g15 ⚠
aminopeptidase
— OG7
C4B63_242g2 ⚠
protein kinase
— OG7
C4B63_58g54 ⚠
serine/threonine protein kinase
— OG7
C4B63_54g24 ⚠
ATP-dependent DEAD/H RNA helicase
— OG7
C4B63_6g420 ⚠
Probable 28S rRNA (cytosine-C(5))-methyltrans
— OG7
C4B63_9g523 ⚠
U5 small nuclear ribonucleoprotein component
— OG7
C4B63_11g17 ⚠
translation elongation factor EF-2
— OG7
C4B63_11g18 ⚠
translation elongation factor EF-2
— OG7
C4B63_23g124 ⚠
NOL1/NOP2/sun family
— OG7
C4B63_301g7 ⚠
conserved hypothetical protein
— OG7
C4B63_63g31 ⚠
Carboxy-terminal domain RNA polymerase II pol
— OG7
C4B63_44g246 ⚠
nucleolar protein
— OG7
C4B63_23g189 ⚠
Uncharacterized protein C2F7.02c
— OG7
C4B63_48g7 ⚠
NLI interacting factor-like phosphatase
— OG7
C4B63_2g522 ⚠
choline kinase
— OG7
C4B63_11g24 ⚠
TFIIF-stimulated CTD phosphatase
— OG7
C4B63_2g833 ⚠
Probable C-terminal domain small phosphatase
— OG7
C4B63_13g41 ⚠
protein kinase
— OG7
C4B63_23g122 ⚠
serine/threonine protein kinase
— OG7
C4B63_13g231 ⚠
serine/threonine protein kinase
— OG7
C4B63_6g161 ⚠
Eukaryotic initiation factor 4A-1
— OG7
C4B63_76g131 ⚠
protein kinase
— OG7
C4B63_54g35 ⚠
protein kinase
— OG7
C4B63_6g391 ⚠
protein kinase
— OG7
C4B63_70g82 ⚠
protein kinase
— OG7
C4B63_9g484 ⚠
5-methylcytosine rRNA methyltransferase NSUN4
— OG7
C4B63_54g5 ⚠
TFIIF-stimulated CTD phosphatase
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.