C4B63_21g61

guanine nucleotide exchange factor subunit GCD7
Trypanosoma cruzi Dm28c 2018 OG6: OG6_102470 OG7: OG7_0001817 83 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 83 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_13g297 ⚠
Axonemal inner arm dynein light chain
— OG7
C4B63_124g1 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_16g103 ⚠
conserved hypothetical protein
— OG7
C4B63_13g334 ⚠
conserved hypothetical protein
— OG7
C4B63_17g277 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_58g144 ⚠
Cilia- and flagella-associated protein 70
— OG7
C4B63_8g48 ⚠
dynein arm light chain
— OG7
C4B63_46g32 ⚠
E3 ubiquitin-protein ligase HERC2
— OG7
C4B63_24g196 ⚠
microtubule-associated protein
— OG7
C4B63_17g276 ⚠
TRAF3-interacting protein 1
— OG7
C4B63_137g7 ⚠
leucine-rich repeat protein (LRRP)
— OG7
C4B63_10g132 ⚠
conserved hypothetical protein
— OG7
C4B63_2g729 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
C4B63_6g276 ⚠
leucine-rich repeat protein (LRRP)
— OG7
C4B63_7g236 ⚠
regulatory subunit of protein kinase a-like p
— OG7
C4B63_31g46 ⚠
structural maintenance of chromosome 3 protei
— OG7
C4B63_4g103 ⚠
intraflagellar transport protein 140
— OG7
C4B63_17g278 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_102g78 ⚠
dynein arm light chain
— OG7
C4B63_4g506 ⚠
Microtubule Associated kinase (CAP-Gly domain
— OG7
C4B63_32g247 ⚠
conserved hypothetical protein
— OG7
C4B63_7g67 ⚠
Sec7 guanine-nucleotide exchange factor
— OG7
C4B63_6g572 ⚠
5'-3' exoribonuclease A
— OG7
C4B63_25g220 ⚠
5'-3' exoribonuclease B
— OG7
C4B63_48g116 ⚠
5'-3' exoribonuclease D
— OG7
C4B63_38g151 ⚠
tetratricopeptide repeat protein (TPR)
— OG7
C4B63_38g152 ⚠
tetratricopeptide repeat protein (TPR)
— OG7
C4B63_12g196 ⚠
conserved hypothetical protein
— OG7
C4B63_70g123 ⚠
3-methylcrotonoyl-CoA carboxylase beta subuni
— OG7
C4B63_56g95 ⚠
paraflagellar rod protein
— OG7
C4B63_1g57 ⚠
AAA ATPase
— OG7
C4B63_7g68 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_24g194 ⚠
microtubule-associated protein
— OG7
C4B63_87g20 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_7g57 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_87g21 ⚠
conserved hypothetical protein
— OG7
C4B63_7g55 ⚠
conserved hypothetical protein
— OG7
C4B63_81g14 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_7g56 ⚠
Protein transport protein sec71
— OG7
C4B63_81g15 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_21g49 ⚠
conserved hypothetical protein
— OG7
C4B63_52g40 ⚠
immunodominant antigen
— OG7
C4B63_207g2 ⚠
fibrillarin
— OG7
C4B63_43g187 ⚠
structural maintenance of chromosome protein
— OG7
C4B63_42g198 ⚠
conserved hypothetical protein
— OG7
C4B63_43g154 ⚠
TRAF3-interacting protein 1
— OG7
C4B63_7g380 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_89g51 ⚠
FYVE zinc-finger containing protein
— OG7
C4B63_7g424 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_28g113 ⚠
dynein arm light chain
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.