C4B63_21g49

conserved hypothetical protein
Trypanosoma cruzi Dm28c 2018 OG6: OG6_157995 OG7: OG7_0052131 101 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 101 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_14g249 ⚠
structural maintenance of chromosome 3
— Both
C4B63_87g21 ⚠
conserved hypothetical protein
— Both
C4B63_87g20 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— Both
C4B63_56g95
paraflagellar rod protein
— Both
C4B63_6g572 ⚠
5'-3' exoribonuclease A
— Both
C4B63_3g494 ⚠
Mucin-associated surface protein (MASP)
— OG6
C4B63_3g241 ⚠
mucin TcMUC
— OG6
C4B63_48g116 ⚠
5'-3' exoribonuclease D
— Both
C4B63_3g686 ⚠
Mucin-associated surface protein (MASP)
— OG6
C4B63_125g66 ⚠
Mucin-associated surface protein (MASP)
— OG6
C4B63_45g234 ⚠
ubiquitin-protein ligase-like
— OG6
C4B63_45g236 ⚠
ubiquitin-protein ligase
— OG6
C4B63_45g232 ⚠
ubiquitin-protein ligase-like
— OG6
C4B63_45g235 ⚠
ubiquitin-protein ligase-like
— OG6
C4B63_10g106 ⚠
kinesin
— OG6
C4B63_63g101 ⚠
Phosphatidylinositol 3-kinase tor1
— Both
C4B63_4g481 ⚠
Flagellum attachment zone protein 7
— OG6
C4B63_293g22 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG6
C4B63_16g102 ⚠
conserved hypothetical protein
— Both
C4B63_16g101 ⚠
conserved hypothetical protein
— Both
C4B63_42g254
conserved hypothetical protein
— Both
C4B63_293g21 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG6
C4B63_76g43
proteasome regulatory ATPase subunit 1
— OG6
C4B63_89g42 ⚠
translation initiation factor EIF-2b alpha su
— Both
C4B63_11g50
General negative regulator of transcription s
— Both
C4B63_80g40
conserved hypothetical protein
— Both
C4B63_4g513
Target of rapamycin complex subunit LST8
— Both
C4B63_79g36 ⚠
CCR4-NOT transcription complex subunit 1
— Both
C4B63_293g24 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG6
C4B63_24g195 ⚠
microtubule-associated protein
— Both
C4B63_24g194 ⚠
microtubule-associated protein
— Both
C4B63_4g506 ⚠
Microtubule Associated kinase (CAP-Gly domain
— Both
C4B63_4g531
Cleavage stimulation factor subunit 1
— Both
C4B63_4g72 ⚠
fibrillarin
— Both
C4B63_207g2 ⚠
fibrillarin
— Both
C4B63_51g179
conserved hypothetical protein
— Both
C4B63_7g424 ⚠
phosphatidylinositol 3-kinase(fragment)
— Both
C4B63_89g51
FYVE zinc-finger containing protein
— Both
C4B63_86g69 ⚠
mucin TcMUCII
— OG6
C4B63_57g113
Flagellar Member 2
— Both
C4B63_26g246
protein kinase
— OG6
C4B63_43g187 ⚠
structural maintenance of chromosome protein
— Both
C4B63_57g88 ⚠
fibrillarin
— Both
C4B63_9g224 ⚠
Cilia- and flagella-associated protein 57
— Both
C4B63_9g223 ⚠
Cilia- and flagella-associated protein 57
— Both
C4B63_4g103
intraflagellar transport protein 140
— Both
C4B63_293g23 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG6
C4B63_17g45
kinesin
— OG6
C4B63_63g98
ubiquitin-protein ligase
— OG6
C4B63_10g105 ⚠
kinesin protein
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.