C4B63_4g513

Target of rapamycin complex subunit LST8
Trypanosoma cruzi Dm28c 2018 OG6: OG6_146807 OG7: OG7_0007715 158 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 158 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_7g57 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_2g292 ⚠
glyceraldehyde-3-phosphate dehydrogenase
— OG6
C4B63_183g99c ⚠
conserved hypothetical protein
— Both
C4B63_38g151 ⚠
tetratricopeptide repeat protein (TPR)
— Both
C4B63_38g152 ⚠
tetratricopeptide repeat protein (TPR)
— Both
C4B63_8g41
RNA-binding protein
— OG6
C4B63_23g242 ⚠
radial spoke protein RSP10
— Both
C4B63_34g361 ⚠
phosphatidylinositol kinase related protein
— Both
C4B63_128g60
zinc-finger protein family member
— Both
C4B63_149g26
GDP-mannose pyrophosphorylase
— Both
C4B63_31g181 ⚠
mitochondrial DNA polymerase beta
— Both
C4B63_4g497 ⚠
GDP-mannose 4,6 dehydratase
— Both
C4B63_4g500 ⚠
GDP-mannose 4,6 dehydratase
— Both
C4B63_4g481 ⚠
Flagellum attachment zone protein 7
— OG6
C4B63_4g480 ⚠
Flagellum attachment zone protein 7(fragment)
— OG6
C4B63_30g161 ⚠
glutamine synthetase
— Both
C4B63_143g20 ⚠
glutamine synthetase
— Both
C4B63_9g201 ⚠
GTP-binding protein
— Both
C4B63_184g8 ⚠
GTP-binding protein
— Both
C4B63_7g391 ⚠
ubiquitin hydrolase
— Both
C4B63_7g392 ⚠
ubiquitin hydrolase
— Both
C4B63_52g40
immunodominant antigen
— Both
C4B63_30g273 ⚠
conserved hypothetical protein
— Both
C4B63_163g31 ⚠
conserved hypothetical protein
— Both
C4B63_41g200 ⚠
Anaphase-promoting complex subunit 8
— Both
C4B63_89g42 ⚠
translation initiation factor EIF-2b alpha su
— Both
C4B63_6g433
conserved hypothetical protein
— Both
C4B63_1g57
AAA ATPase
— Both
C4B63_20g355 ⚠
HSPBP1
— Both
C4B63_268g24 ⚠
HSPBP1
— Both
C4B63_281g8 ⚠
translation initiation factor eIF2B delta sub
— OG7
C4B63_21g61 ⚠
guanine nucleotide exchange factor subunit GC
— OG7
C4B63_19g15 ⚠
translation initiation factor eIF2B delta sub
— OG7
C4B63_33g8 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— OG7
C4B63_29g3 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— OG7
C4B63_56g104 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— OG7
C4B63_81g15 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_7g56 ⚠
Protein transport protein sec71
— OG7
C4B63_81g14 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_7g55 ⚠
conserved hypothetical protein
— OG7
C4B63_22g288
Midasin
— OG7
C4B63_42g198 ⚠
conserved hypothetical protein
— OG7
C4B63_43g154 ⚠
TRAF3-interacting protein 1
— OG7
C4B63_28g113 ⚠
dynein arm light chain
— OG7
C4B63_42g199 ⚠
conserved hypothetical protein
— OG7
C4B63_80g15 ⚠
cAMP response protein 1
— OG7
C4B63_2g729 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
C4B63_51g192 ⚠
protein kinase A regulatory subunit
— OG7
C4B63_168g31 ⚠
dynein arm light chain
— OG7
C4B63_7g236 ⚠
regulatory subunit of protein kinase a-like p
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.