C4B63_9g201

GTP-binding protein
Trypanosoma cruzi Dm28c 2018 OG6: OG6_100571 OG7: OG7_0003363 78 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 78 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_58g137 ⚠
conserved hypothetical protein
— Both
C4B63_396g16 ⚠
Spindle assembly abnormal protein 6 homolog
— OG7
C4B63_39g333 ⚠
eukaryotic translation initiation factor 3 su
— OG7
C4B63_9g231 ⚠
esterase
— Both
C4B63_184g21 ⚠
esterase
— Both
C4B63_9g216 ⚠
esterase
— Both
C4B63_17g99 ⚠
exportin 1
— Both
C4B63_142g6 ⚠
GMP synthase
— Both
C4B63_238g18 ⚠
GMP synthase(fragment)
— Both
C4B63_58g136 ⚠
conserved hypothetical protein
— Both
C4B63_26g232 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_99g106 ⚠
monothiol glutaredoxin
— Both
C4B63_241g7 ⚠
Leucine-rich repeat-containing protein 34
— Both
C4B63_21g282 ⚠
mitogen-activated protein kinase 3
— OG6
C4B63_17g233 ⚠
iron superoxide dismutase
— Both
C4B63_9g488 ⚠
conserved hypothetical protein
— Both
C4B63_268g24 ⚠
HSPBP1
— Both
C4B63_47g80 ⚠
Gamma-soluble NSF attachment protein
— Both
C4B63_14g782c ⚠
monothiol glutaredoxin
— Both
C4B63_25g240 ⚠
Macro domain containing protein
— Both
C4B63_69g55 ⚠
monothiol glutaredoxin
— OG7
C4B63_17g188 ⚠
Phosphopantetheine adenylyltransferase
— OG7
C4B63_233g31 ⚠
ubiquitin hydrolase
— OG7
C4B63_233g32 ⚠
ubiquitin hydrolase
— OG7
C4B63_2g210 ⚠
Spindle assembly abnormal protein 6 homolog
— OG7
C4B63_31g180 ⚠
mitochondrial DNA polymerase beta-PAK
— OG7
C4B63_7g392 ⚠
ubiquitin hydrolase
— OG7
C4B63_396g15 ⚠
Spindle assembly abnormal protein 6 homolog
— OG7
C4B63_6g433 ⚠
conserved hypothetical protein
— OG7
C4B63_2g396 ⚠
conserved hypothetical protein
— OG7
C4B63_48g23 ⚠
nicotinate phosphoribosyltransferase
— Both
C4B63_31g179 ⚠
mitochondrial DNA polymerase beta-PAK
— OG7
C4B63_114g20 ⚠
C-1-tetrahydrofolate synthase, cytoplasmic
— OG7
C4B63_4g500 ⚠
GDP-mannose 4,6 dehydratase
— OG7
C4B63_26g231 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_7g391 ⚠
ubiquitin hydrolase
— OG7
C4B63_2g4 ⚠
ubiquitin hydrolase
— OG7
C4B63_144g24 ⚠
monothiol glutaredoxin
— OG7
C4B63_4g497 ⚠
GDP-mannose 4,6 dehydratase
— OG7
C4B63_21g253 ⚠
Mitogen-activated protein kinase 10
— OG6
C4B63_19g188 ⚠
conserved hypothetical protein
— Both
C4B63_31g181 ⚠
mitochondrial DNA polymerase beta
— Both
C4B63_112g17 ⚠
conserved hypothetical protein
— Both
C4B63_18g151 ⚠
conserved hypothetical protein
— Both
C4B63_4g513 ⚠
Target of rapamycin complex subunit LST8
— Both
C4B63_7g361 ⚠
phosphomannomutase-like protein
— Both
C4B63_396g13 ⚠
Lateral signaling target protein 2 homolog
— OG6
C4B63_4g348 ⚠
Bifunctional coenzyme A synthase
— Both
C4B63_3g1086 ⚠
monothiol glutaredoxin
— Both
C4B63_2g486 ⚠
Serine-threonine kinase receptor-associated p
— Both
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.