C4B63_9g488

conserved hypothetical protein

Trypanosoma cruzi Dm28c 2018 OG6: OG6_158116 OG7: OG7_0042613 207 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 207 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_17g188 ⚠ Phosphopantetheine adenylyltransferase	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_004096 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_004096 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_006158	Both
C4B63_9g331 ⚠ transcription elongation factor s-II	—	OG6 TCSYLVIO_000382 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_000382 ↔ TCSYLVIO_004051	Both
C4B63_112g17 conserved hypothetical protein	—	OG6 TCSYLVIO_001734 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_001734 ↔ TCSYLVIO_004051	Both
C4B63_279g8 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG6 TCSYLVIO_002972 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_002972 ↔ TCSYLVIO_004051	Both
C4B63_44g252 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG6 TCSYLVIO_002972 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_002972 ↔ TCSYLVIO_004051	Both
C4B63_69g27 35 kDa cyclophilin	—	OG6 TCSYLVIO_003462 ↔ TCSYLVIO_004051	OG6
C4B63_230g26 ⚠ tRNA threonylcarbamoyl adenosine modification	—	OG6 TCSYLVIO_002651 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_002651 ↔ TCSYLVIO_004051	Both
C4B63_6g385 ⚠ tRNA threonylcarbamoyl adenosine modification	—	OG6 TCSYLVIO_002651 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_002651 ↔ TCSYLVIO_004051	Both
C4B63_60g172 conserved hypothetical protein	—	OG6 TCSYLVIO_001224 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_001224 ↔ TCSYLVIO_004051	Both
C4B63_114g23 UBX domain-containing protein 3	—	OG6 TCSYLVIO_001163 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_001163 ↔ TCSYLVIO_004051	Both
C4B63_16g163 Pyridoxal phosphate homeostasis protein	—	OG6 TCSYLVIO_000216 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_000216 ↔ TCSYLVIO_004051	Both
C4B63_30g145 electron-transfer-flavoprotein, alpha polypep	—	OG6 TCSYLVIO_001784 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_001784 ↔ TCSYLVIO_004051	Both
C4B63_30g144 Cilia- and flagella-associated protein 52	—	OG6 TCSYLVIO_001783 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_001783 ↔ TCSYLVIO_004051	Both
C4B63_7g361 phosphomannomutase-like protein	—	OG6 TCSYLVIO_003734 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_003734 ↔ TCSYLVIO_004051	Both
C4B63_184g8 ⚠ GTP-binding protein	—	OG6 TCSYLVIO_000468 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_000468 ↔ TCSYLVIO_004051	Both
C4B63_9g201 ⚠ GTP-binding protein	—	OG6 TCSYLVIO_000468 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_000468 ↔ TCSYLVIO_004051	Both
C4B63_18g30 ⚠ epsilon-adaptin	—	OG6 TCSYLVIO_003203 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_003203 ↔ TCSYLVIO_004051	Both
C4B63_6g148 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 TCSYLVIO_002576 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_002576 ↔ TCSYLVIO_004051	Both
C4B63_28g64 ⚠ aspartate aminotransferase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_004051	Both
C4B63_6g146 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 TCSYLVIO_002576 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_002576 ↔ TCSYLVIO_004051	Both
C4B63_54g69 ⚠ aspartate aminotransferase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_004051	Both
C4B63_253g15 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 TCSYLVIO_002576 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_002576 ↔ TCSYLVIO_004051	Both
C4B63_18g278 RNA-binding protein	—	OG6 TCSYLVIO_003292 ↔ TCSYLVIO_004051	OG6
C4B63_17g99 exportin 1	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_004194 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_004194	Both
C4B63_58g136 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_006832 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_006832	Both
C4B63_58g137 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_006832 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_006832	Both
C4B63_175g8 ⚠ TPR-repeat protein	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_009926	OG6
C4B63_17g264 ⚠ phosphomannose isomerase	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_004145 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_004145	Both
C4B63_25g240 Macro domain containing protein	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_008897 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_008897	Both
C4B63_23g269 conserved hypothetical protein	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_004472 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_004472	Both
C4B63_14g782c ⚠ monothiol glutaredoxin	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_007499 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_007499	Both
C4B63_47g80 Gamma-soluble NSF attachment protein	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_004539 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_004539	Both
C4B63_31g106 conserved hypothetical protein	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_010565 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_010565	Both
C4B63_9g516 heat shock protein Hsp20	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_004068 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_004068	Both
C4B63_31g228 ⚠ dihydroorotase	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_008471 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_008471	Both
C4B63_17g233 ⚠ iron superoxide dismutase	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_010549 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_010549	Both
C4B63_21g282 mitogen-activated protein kinase 3	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_007367	OG6
C4B63_58g38 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_006876 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_006876	Both
C4B63_4g383 ⚠ mevalonate-diphosphate decarboxylase	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_006134 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_006134	Both
C4B63_10g147 ⚠ carnitine O-acetyltransferase(fragment)	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_004300	OG6
C4B63_4g136 ⚠ N-myristoyl transferase	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_006126 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_006126	Both
C4B63_35g191 6-phosphogluconolactonase	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_007658 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_007658	Both
C4B63_4g357 Activator of 90 kDa heat shock protein ATPase	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_006151 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_006151	Both
C4B63_99g106 ⚠ monothiol glutaredoxin	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_007499 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_007499	Both
C4B63_241g7 ⚠ Leucine-rich repeat-containing protein 34	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_007538 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_007538	Both
C4B63_14g17 ⚠ small G-protein	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_004644	OG6
C4B63_11g25 conserved hypothetical protein	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_006390 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_006390	Both
C4B63_184g9 ⚠ protein phosphatase 2C	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_007482	OG6
C4B63_188g43 conserved hypothetical protein	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_009863 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_009863	Both
C4B63_259g9 ⚠ Ran-binding protein	—	OG6 TCSYLVIO_000197 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_000197 ↔ TCSYLVIO_004051	Both

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