C4B63_89g51

FYVE zinc-finger containing protein
Trypanosoma cruzi Dm28c 2018 OG6: OG6_156908 OG7: OG7_0019980 145 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 145 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_31g98
Autophagy protein Apg6
— OG7
C4B63_18g72 ⚠
cyclosome subunit
— Both
C4B63_52g40
immunodominant antigen
— Both
C4B63_35g116 ⚠
VPS13A C
— OG6
C4B63_87g21 ⚠
conserved hypothetical protein
— Both
C4B63_87g20 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— Both
C4B63_56g95
paraflagellar rod protein
— Both
C4B63_143g33 ⚠
inorganic polyphosphate/ATP-NAD kinase
— Both
C4B63_30g176 ⚠
inorganic polyphosphate/ATP-NAD kinase
— Both
C4B63_6g572 ⚠
5'-3' exoribonuclease A
— Both
C4B63_3g494 ⚠
Mucin-associated surface protein (MASP)
— OG6
C4B63_3g241 ⚠
mucin TcMUC
— OG6
C4B63_48g116 ⚠
5'-3' exoribonuclease D
— Both
C4B63_3g686 ⚠
Mucin-associated surface protein (MASP)
— OG6
C4B63_125g66 ⚠
Mucin-associated surface protein (MASP)
— OG6
C4B63_45g234 ⚠
ubiquitin-protein ligase-like
— OG6
C4B63_45g236 ⚠
ubiquitin-protein ligase
— OG6
C4B63_45g232 ⚠
ubiquitin-protein ligase-like
— OG6
C4B63_45g235 ⚠
ubiquitin-protein ligase-like
— OG6
C4B63_85g63
Rab-GTPase-TBC domain containing protein
— Both
C4B63_21g49
conserved hypothetical protein
— Both
C4B63_38g151 ⚠
tetratricopeptide repeat protein (TPR)
— Both
C4B63_38g152 ⚠
tetratricopeptide repeat protein (TPR)
— Both
C4B63_34g361 ⚠
phosphatidylinositol kinase related protein
— Both
C4B63_128g60
zinc-finger protein family member
— Both
C4B63_89g42 ⚠
translation initiation factor EIF-2b alpha su
— Both
C4B63_1g57
AAA ATPase
— Both
C4B63_281g8 ⚠
translation initiation factor eIF2B delta sub
— OG7
C4B63_21g61 ⚠
guanine nucleotide exchange factor subunit GC
— OG7
C4B63_19g15 ⚠
translation initiation factor eIF2B delta sub
— OG7
C4B63_81g15 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_7g56 ⚠
Protein transport protein sec71
— OG7
C4B63_81g14 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_7g55 ⚠
conserved hypothetical protein
— OG7
C4B63_7g57 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_7g67 ⚠
Sec7 guanine-nucleotide exchange factor
— OG7
C4B63_7g68 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_31g46 ⚠
structural maintenance of chromosome 3 protei
— OG7
C4B63_32g248
conserved hypothetical protein
— OG7
C4B63_80g15 ⚠
cAMP response protein 1
— OG7
C4B63_4g331 ⚠
tubulin-specific chaperone
— OG7
C4B63_204g23 ⚠
Axonemal inner arm dynein light chain
— OG7
C4B63_2g828 ⚠
ankyrin repeat protein
— OG7
C4B63_22g166 ⚠
Regulatory-associated protein of mTOR
— OG7
C4B63_55g168 ⚠
Cilia- and flagella-associated protein 57
— OG7
C4B63_102g78 ⚠
dynein arm light chain
— OG7
C4B63_10g132
conserved hypothetical protein
— OG7
C4B63_46g32
E3 ubiquitin-protein ligase HERC2
— OG7
C4B63_7g306 ⚠
cleavage and polyadenylation specificity fact
— OG7
C4B63_13g297 ⚠
Axonemal inner arm dynein light chain
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.