C4B63_49g160

ATP-dependent DEAD/H RNA helicase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_126543 OG7: OG7_0000698 104 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 104 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_6g322 ⚠
conserved hypothetical protein
— OG6
C4B63_134g35 ⚠
ubiquitin hydrolase
— OG6
C4B63_26g275 ⚠
protein phosphatase 2A regulatory subunit
— OG6
C4B63_89g42 ⚠
translation initiation factor EIF-2b alpha su
— OG6
C4B63_85g46 ⚠
Ring finger domain/Zn-finger in ubiquitin-hyd
— OG6
C4B63_2g750 ⚠
death-receptor fusion protein (DUF2428)
— OG6
C4B63_14g80 ⚠
conserved hypothetical protein
— OG6
C4B63_10g106 ⚠
kinesin
— OG6
C4B63_13g240 ⚠
conserved hypothetical protein
— OG6
C4B63_137g49 ⚠
conserved hypothetical protein
— OG6
C4B63_63g101 ⚠
Phosphatidylinositol 3-kinase tor1
— OG6
C4B63_2g5 ⚠
casein kinase II
— OG6
C4B63_16g102 ⚠
conserved hypothetical protein
— OG6
C4B63_16g101 ⚠
conserved hypothetical protein
— OG6
C4B63_42g254 ⚠
conserved hypothetical protein
— OG6
C4B63_2g760 ⚠
60S ribosomal subunit protein L31
— OG6
C4B63_2g759 ⚠
60S ribosomal subunit protein L31
— OG6
C4B63_23g222 ⚠
serine/threonine-protein kinase Nek
— OG6
C4B63_120g74 ⚠
Putative intraflagellar transport protein A1(
— OG6
C4B63_18g295 ⚠
conserved hypothetical protein
— OG6
C4B63_2g449 ⚠
Unc104-like kinesin
— OG6
C4B63_14g79 ⚠
conserved hypothetical protein
— OG6
C4B63_11g50 ⚠
General negative regulator of transcription s
— OG6
C4B63_14g81 ⚠
conserved hypothetical protein
— OG6
C4B63_24g195 ⚠
microtubule-associated protein
— OG6
C4B63_24g194 ⚠
microtubule-associated protein
— OG6
C4B63_63g98 ⚠
ubiquitin-protein ligase
— OG6
C4B63_76g43 ⚠
proteasome regulatory ATPase subunit 1
— OG6
C4B63_1g57 ⚠
AAA ATPase
— OG6
C4B63_18g263 ⚠
SPA/DENN domain containing protein
— OG6
C4B63_47g47 ⚠
U3 small nucleolar RNA-interacting protein 2
— OG6
C4B63_9g378 ⚠
conserved hypothetical protein
— OG6
C4B63_16g103 ⚠
conserved hypothetical protein
— OG6
C4B63_13g334 ⚠
conserved hypothetical protein
— OG6
C4B63_8g48 ⚠
dynein arm light chain
— OG6
C4B63_2g448 ⚠
Unc104-like kinesin
— OG6
C4B63_10g105 ⚠
kinesin protein
— OG6
C4B63_17g276 ⚠
TRAF3-interacting protein 1
— OG6
C4B63_24g196 ⚠
microtubule-associated protein
— OG6
C4B63_18g156 ⚠
protein mkt1
— OG6
C4B63_4g531 ⚠
Cleavage stimulation factor subunit 1
— OG6
C4B63_7g424 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG6
C4B63_14g93 ⚠
Cyclin 12, L-type
— OG6
C4B63_12g294 ⚠
Putative intraflagellar transport protein A1
— OG6
C4B63_9g224 ⚠
Cilia- and flagella-associated protein 57
— OG6
C4B63_9g223 ⚠
Cilia- and flagella-associated protein 57
— OG6
C4B63_2g447 ⚠
Unc104-like kinesin(fragment)
— OG6
C4B63_101g26 ⚠
conserved hypothetical protein
— OG6
C4B63_17g45 ⚠
kinesin
— OG6
C4B63_35g128 ⚠
ubiquitin hydrolase
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.