C4B63_2g566

phenylalanyl-tRNA synthetase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_101233 OG7: OG7_0004252 232 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 232 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_42g202 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_342110.1	OG7
C4B63_63g95 ⚠ poly(A)-specific ribonuclease PARN	—	OG6 LdBPK_191010.1 ↔ LdBPK_230660.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_230660.1	Both
C4B63_32g238 ⚠ tubulin folding cofactor D	—	OG6 LdBPK_191010.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_242100.1	Both
C4B63_16g30 ⚠ poly(A)-specific ribonuclease PARN	—	OG6 LdBPK_191010.1 ↔ LdBPK_230660.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_230660.1	Both
C4B63_32g239 ⚠ tubulin folding cofactor D	—	OG6 LdBPK_191010.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_242100.1	Both
C4B63_14g155 Leucine-rich repeat-containing protein 74A	—	OG6 LdBPK_191010.1 ↔ LdBPK_364440.1 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005548	Both
C4B63_160g6 ⚠ poly(A)-specific ribonuclease PARN	—	OG6 LdBPK_191010.1 ↔ LdBPK_230660.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_230660.1	Both
C4B63_42g187 conserved hypothetical protein	—	OG6 LdBPK_191010.1 ↔ LdBPK_300580.1 OG6 TCSYLVIO_003118 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_300580.1	Both
C4B63_2g74 ⚠ poly(A)-specific ribonuclease PARN(fragment)	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_230660.1	OG7
C4B63_2g75 ⚠ poly(A)-specific ribonuclease PARN(fragment)	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_230660.1	OG7
C4B63_7g79 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003867 ↔ TCSYLVIO_005548 OG6 LdBPK_191010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_342110.1	Both
C4B63_297g14 ⚠ phenylalanyl-tRNA synthetase alpha chain	—	OG6 TCSYLVIO_004213 ↔ TCSYLVIO_005548 OG6 Tb927.11.14120 ↔ Tb927.11.2360 OG7 Tb927.11.14120 ↔ Tb927.11.2360 OG7 TCSYLVIO_004213 ↔ TCSYLVIO_005548	Both
C4B63_17g69 ⚠ phenylalanyl-tRNA synthetase alpha chain	—	OG6 TCSYLVIO_004213 ↔ TCSYLVIO_005548 OG6 Tb927.11.14120 ↔ Tb927.11.2360 OG7 Tb927.11.14120 ↔ Tb927.11.2360 OG7 TCSYLVIO_004213 ↔ TCSYLVIO_005548	Both
C4B63_42g203 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_342110.1	OG7
C4B63_168g16 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_342110.1	OG7
C4B63_102g61 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_342110.1	OG7
C4B63_7g377 ⚠ [Pyruvate dehydrogenase (acetyl-transferring)	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_240010.1	OG7
C4B63_41g119 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_191010.1	OG7
C4B63_41g125 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_191010.1	OG7
C4B63_41g122 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_191010.1	OG7
C4B63_224g16 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_191010.1	OG7
C4B63_41g128 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_191010.1	OG7
C4B63_31g99 WD repeat-containing protein 17	—	OG6 TCSYLVIO_005548 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_191010.1 OG7 TCSYLVIO_005548 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_191010.1	Both
C4B63_22g11 ⚠ developmentally regulated phosphoprotein	—	OG6 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_240010.1	Both
C4B63_28g25 ⚠ pyruvate dehydrogenase (lipoamide) kinase	—	OG6 TCSYLVIO_001571 ↔ TCSYLVIO_005548 OG6 LdBPK_191010.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005548 +1 more	Both
C4B63_23g264 ⚠ 6-phosphofructo-2-kinase 1	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_005548	OG7
C4B63_21g30 ⚠ Exportin-7-A	—	OG6 TCSYLVIO_003586 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_005548	Both
C4B63_23g248 ⚠ inorganic pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005548	Both
C4B63_70g77 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005548	Both
C4B63_54g57 vacuolar ATP synthase subunit d	—	OG6 TCSYLVIO_005104 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_005104 ↔ TCSYLVIO_005548	Both
C4B63_45g239 ⚠ lysyl-tRNA synthetase	—	OG6 Tb927.11.2360 ↔ Tb927.8.1600 OG7 Tb927.11.2360 ↔ Tb927.8.1600	Both
C4B63_42g247 ⚠ lysyl-tRNA synthetase	—	OG6 Tb927.11.2360 ↔ Tb927.8.1600 OG7 Tb927.11.2360 ↔ Tb927.8.1600	Both
C4B63_21g255 ⚠ Nucleolar protein 56	—	OG6 Tb927.11.2360 ↔ Tb927.8.3750 OG7 Tb927.11.2360 ↔ Tb927.8.3750	Both
C4B63_2g450 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005548	OG7
C4B63_23g242 ⚠ radial spoke protein RSP10	—	OG7 TCSYLVIO_001987 ↔ TCSYLVIO_005548	OG7
C4B63_45g121 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_005548	OG7
C4B63_330g12 ⚠ Eukaryotic translation initiation factor 4E-4	—	OG7 LdBPK_191010.1 ↔ LdBPK_300460.1	OG7
C4B63_25g219 ⚠ conserved hypothetical protein	—	OG7 LdBPK_120470.1 ↔ LdBPK_191010.1	OG7
C4B63_9g266 ⚠ paraflagellar rod protein 5	—	OG7 TCSYLVIO_004334 ↔ TCSYLVIO_005548	OG7
C4B63_10g289 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_004334 ↔ TCSYLVIO_005548	OG7
C4B63_9g267 ⚠ paraflagellar rod protein 5	—	OG7 TCSYLVIO_004334 ↔ TCSYLVIO_005548	OG7
C4B63_10g290 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_004334 ↔ TCSYLVIO_005548	OG7
C4B63_10g288 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_004334 ↔ TCSYLVIO_005548	OG7
C4B63_10g287 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_004334 ↔ TCSYLVIO_005548	OG7
C4B63_513g4 ⚠ eukaryotic translation initiation factor 4E (	—	OG7 LdBPK_191010.1 ↔ LdBPK_300460.1	OG7
C4B63_13g160 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-bisphos	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_005548	OG7
C4B63_24g301 phosphatidylinositol-4-phosphate 5-kinase	—	OG7 LdBPK_191010.1 ↔ LdBPK_291830.1	OG7
C4B63_39g340 ⚠ replication factor C, subunit 4	—	OG7 LdBPK_191010.1 ↔ LdBPK_241010.1	OG7
C4B63_6g252 ⚠ Centrosomal protein of 164 kDa	—	OG7 LdBPK_120470.1 ↔ LdBPK_191010.1	OG7
C4B63_25g218 ⚠ Centrosomal protein of 164 kDa	—	OG7 LdBPK_120470.1 ↔ LdBPK_191010.1	OG7

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