C4B63_23g264

6-phosphofructo-2-kinase 1
Trypanosoma cruzi Dm28c 2018 OG6: OG6_100250 OG7: OG7_0002306 196 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 196 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_13g166 ⚠
leucine carboxyl methyltransferase
— OG7
C4B63_14g155 ⚠
Leucine-rich repeat-containing protein 74A
— Both
C4B63_391g15 ⚠
conserved hypothetical protein
— Both
C4B63_84g63 ⚠
conserved hypothetical protein
— Both
C4B63_2g799 ⚠
tRNA wybutosine-synthesizing protein 4
— Both
C4B63_31g99 ⚠
WD repeat-containing protein 17
— OG7
C4B63_43g126 ⚠
ATP synthase F1 subunit gamma protein
— OG7
C4B63_2g551 ⚠
Eukaryotic translation initiation factor 4E-1
— OG7
C4B63_42g204 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
C4B63_17g69 ⚠
phenylalanyl-tRNA synthetase alpha chain
— OG7
C4B63_43g202 ⚠
hook complex protein, conserved
— OG7
C4B63_2g203 ⚠
synaptojanin (N-terminal domain)
— OG7
C4B63_224g16 ⚠
conserved hypothetical protein
— OG7
C4B63_22g11 ⚠
developmentally regulated phosphoprotein
— OG7
C4B63_2g566 ⚠
phenylalanyl-tRNA synthetase
— OG7
C4B63_42g205 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
C4B63_149g26 ⚠
GDP-mannose pyrophosphorylase
— OG7
C4B63_52g51 ⚠
serine/threonine protein kinase
— OG7
C4B63_7g134 ⚠
conserved hypothetical protein
— OG7
C4B63_41g122 ⚠
conserved hypothetical protein
— OG7
C4B63_41g125 ⚠
conserved hypothetical protein
— OG7
C4B63_40g106 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
C4B63_63g32 ⚠
adaptin-related protein-like
— OG7
C4B63_122g21 ⚠
ubiquitin ligase
— OG7
C4B63_4g577 ⚠
eukaryotic translation initiation factor 4E (
— OG7
C4B63_25g120 ⚠
Protein kinase domain
— OG7
C4B63_42g187 ⚠
conserved hypothetical protein
— OG7
C4B63_14g103 ⚠
beta adaptin
— OG7
C4B63_39g359 ⚠
conserved hypothetical protein
— OG7
C4B63_11g484 ⚠
Leucine Rich Repeat protein
— OG7
C4B63_4g342 ⚠
ATP synthase mitochondrial F1 complex assembl
— OG7
C4B63_4g116 ⚠
FACT complex subunit ssrp1-B
— OG7
C4B63_61g59 ⚠
Protein kinase domain
— OG7
C4B63_171g22 ⚠
eukaryotic translation initiation factor 4E (
— OG7
C4B63_271g10 ⚠
conserved hypothetical protein
— OG7
C4B63_2g365 ⚠
dual-specificity protein kinase
— OG7
C4B63_7g377 ⚠
[Pyruvate dehydrogenase (acetyl-transferring)
— OG7
C4B63_80g25 ⚠
ubiquitin hydrolase
— OG7
C4B63_31g76 ⚠
ubiquitin-activating enzyme
— OG7
C4B63_72g79 ⚠
inositol 5-phosphatase 1
— OG7
C4B63_56g88 ⚠
Zinc finger C2HC domain-containing protein 1C
— OG7
C4B63_28g25 ⚠
pyruvate dehydrogenase (lipoamide) kinase
— OG7
C4B63_41g119 ⚠
conserved hypothetical protein
— OG7
C4B63_83g73 ⚠
ribonucleoprotein p18, mitochondrial precurso
— OG7
C4B63_26g245 ⚠
inositol/phosphatidylinositol phosphatase
— OG7
C4B63_13g113 ⚠
zinc-finger of a C2HC-type
— OG7
C4B63_54g57 ⚠
vacuolar ATP synthase subunit d
— OG7
C4B63_2g513 ⚠
conserved hypothetical protein
— OG7
C4B63_13g257 ⚠
endonuclease/exonuclease/phosphatase
— OG7
C4B63_128g59 ⚠
dihydrolipoamide branched chain transacylase
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.