C4B63_227g20

pyruvate kinase 2
Trypanosoma cruzi Dm28c 2018 OG6: OG6_100258 OG7: OG7_0002165 230 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 230 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_23g248 ⚠
inorganic pyrophosphatase
— Both
C4B63_52g143 ⚠
Bifunctional NAD(P)H-hydrate repair enzyme
— Both
C4B63_70g77 ⚠
acidocalcisomal pyrophosphatase
— Both
C4B63_26g201 ⚠
cAMP specific phosphodiesterase
— Both
C4B63_4g136 ⚠
N-myristoyl transferase
— Both
C4B63_4g137 ⚠
N-myristoyl transferase
— Both
C4B63_69g27 ⚠
35 kDa cyclophilin
— OG6
C4B63_230g26 ⚠
tRNA threonylcarbamoyl adenosine modification
— Both
C4B63_6g385 ⚠
tRNA threonylcarbamoyl adenosine modification
— Both
C4B63_23g200 ⚠
Flagellum attachment zone protein 19
— Both
C4B63_93g64 ⚠
amidohydrolase
— Both
C4B63_93g65 ⚠
amidohydrolase
— Both
C4B63_114g23 ⚠
UBX domain-containing protein 3
— Both
C4B63_16g163 ⚠
Pyridoxal phosphate homeostasis protein
— Both
C4B63_30g145 ⚠
electron-transfer-flavoprotein, alpha polypep
— Both
C4B63_42g217 ⚠
protein phosphatase
— OG6
C4B63_30g144 ⚠
Cilia- and flagella-associated protein 52
— Both
C4B63_17g188 ⚠
Phosphopantetheine adenylyltransferase
— Both
C4B63_7g361 ⚠
phosphomannomutase-like protein
— Both
C4B63_18g232 ⚠
glyceraldehyde 3-phosphate dehydrogenase
— OG6
C4B63_85g51 ⚠
fatty acyl CoA syntetase 1
— Both
C4B63_85g55 ⚠
fatty acyl CoA syntetase 1
— Both
C4B63_150g38 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_22g161 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_57g67 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_10g404 ⚠
guanine deaminase
— Both
C4B63_26g353 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_26g206 ⚠
glutaminyl-tRNA synthetase
— Both
C4B63_206g21 ⚠
fatty acyl CoA synthetase
— Both
C4B63_3g551 ⚠
NADH-dependent fumarate reductase
— Both
C4B63_3g554 ⚠
NADH-dependent fumarate reductase
— Both
C4B63_15g18 ⚠
NADH-dependent fumarate reductase
— Both
C4B63_193g9 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
C4B63_54g70 ⚠
NADH-dependent fumarate reductase
— Both
C4B63_47g115 ⚠
fatty acyl CoA synthetase
— Both
C4B63_20g170 ⚠
glucosamine-6-phosphate isomerase
— Both
C4B63_18g32 ⚠
pseudouridine synthase A-like protein
— Both
C4B63_3g553 ⚠
NADH-dependent fumarate reductase
— Both
C4B63_30g231 ⚠
dihydrofolate reductase-thymidylate synthase
— Both
C4B63_37g364 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_19g45 ⚠
isovaleryl-coA dehydrogenase
— Both
C4B63_18g233 ⚠
glyceraldehyde 3-phosphate dehydrogenase
— OG6
C4B63_22g164 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_46g82 ⚠
adenylosuccinate synthetase
— Both
C4B63_8g249 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_32g236 ⚠
transketolase
— Both
C4B63_25g288 ⚠
inosine-guanine nucleoside hydrolase
— Both
C4B63_70g129 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
C4B63_7g302 ⚠
aldose 1-epimerase-like protein
— Both
C4B63_3g552 ⚠
NADH-dependent fumarate reductase
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.