C4B63_19g45

isovaleryl-coA dehydrogenase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_102105 OG7: OG7_0001034 53 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 53 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_98g4 ⚠
glucose-6-phosphate 1-dehydrogenase
— Both
C4B63_26g206 ⚠
glutaminyl-tRNA synthetase
— Both
C4B63_206g21 ⚠
fatty acyl CoA synthetase
— Both
C4B63_10g404 ⚠
guanine deaminase
— Both
C4B63_295g20 ⚠
tryparedoxin peroxidase
— Both
C4B63_85g55 ⚠
fatty acyl CoA syntetase 1
— Both
C4B63_85g51 ⚠
fatty acyl CoA syntetase 1
— Both
C4B63_48g118
aldehyde dehydrogenase
— Both
C4B63_153g40 ⚠
inositol 5-phosphatase 1
— Both
C4B63_72g79 ⚠
inositol 5-phosphatase 1
— Both
C4B63_26g265
DNA repair protein Rad9
— Both
C4B63_153g41 ⚠
inositol 5-phosphatase 1(fragment)
— Both
C4B63_47g24 ⚠
Glucose-6-phosphate dehydrogenase
— Both
C4B63_135g22 ⚠
Glucose-6-phosphate dehydrogenase
— Both
C4B63_18g164
S-adenosylmethionine synthetase
— Both
C4B63_306g12 ⚠
glucose-6-phosphate 1-dehydrogenase
— Both
C4B63_4g146 ⚠
pyruvate kinase 2
— Both
C4B63_227g20 ⚠
pyruvate kinase 2
— Both
C4B63_41g194 ⚠
glucose-6-phosphate isomerase, glycosomal
— Both
C4B63_248g14 ⚠
glucose-6-phosphate isomerase, glycosomal
— Both
C4B63_13g257 ⚠
endonuclease/exonuclease/phosphatase
— OG7
C4B63_26g245 ⚠
inositol/phosphatidylinositol phosphatase
— OG7
C4B63_2g203 ⚠
synaptojanin (N-terminal domain)
— OG7
C4B63_20g38 ⚠
Synaptojanin
— OG7
C4B63_28g111 ⚠
synaptojanin
— OG7
C4B63_396g8 ⚠
synaptojanin (N-terminal domain)
— OG7
C4B63_18g130 ⚠
glutamyl-tRNA synthetase
— OG7
C4B63_2g425
succinyl-coA:3-ketoacid-coenzyme A transferas
— Both
C4B63_170g28 ⚠
adenylosuccinate synthetase
— Both
C4B63_143g20 ⚠
glutamine synthetase
— Both
C4B63_26g257 ⚠
tryparedoxin peroxidase
— Both
C4B63_26g255 ⚠
tryparedoxin peroxidase
— Both
C4B63_149g19 ⚠
peroxidoxin
— Both
C4B63_149g26
GDP-mannose pyrophosphorylase
— Both
C4B63_12g221 ⚠
pyruvate phosphate dikinase
— Both
C4B63_85g53 ⚠
fatty acyl CoA synthetase 2
— Both
C4B63_348g24 ⚠
guanine deaminase
— Both
C4B63_26g253 ⚠
tryparedoxin peroxidase
— Both
C4B63_47g115 ⚠
fatty acyl CoA synthetase
— Both
C4B63_20g170
glucosamine-6-phosphate isomerase
— Both
C4B63_295g22 ⚠
tryparedoxin peroxidase
— Both
C4B63_220g12 ⚠
peroxidoxin
— Both
C4B63_12g220 ⚠
pyruvate phosphate dikinase
— Both
C4B63_295g16 ⚠
tryparedoxin peroxidase
— Both
C4B63_46g82 ⚠
adenylosuccinate synthetase
— Both
C4B63_86g56 ⚠
glyceraldehyde-3-phosphate dehydrogenase
— OG6
C4B63_2g292 ⚠
glyceraldehyde-3-phosphate dehydrogenase
— OG6
C4B63_30g161 ⚠
glutamine synthetase
— Both
C4B63_295g18 ⚠
tryparedoxin peroxidase
— Both
C4B63_85g54 ⚠
fatty acyl CoA synthetase 2
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.