C4B63_10g404

guanine deaminase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_100650 OG7: OG7_0004147 74 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 74 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_4g146 ⚠
pyruvate kinase 2
— Both
C4B63_90g46 ⚠
cysteine synthase
— OG7
C4B63_248g14 ⚠
glucose-6-phosphate isomerase, glycosomal
— Both
C4B63_41g194 ⚠
glucose-6-phosphate isomerase, glycosomal
— Both
C4B63_9g263 ⚠
trypanothione synthetase
— Both
C4B63_122g4 ⚠
UPF0160 protein C27H6.8
— Both
C4B63_275g17 ⚠
UPF0160 protein C27H6.8
— Both
C4B63_28g60 ⚠
fumarate hydratase
— Both
C4B63_23g130 ⚠
Fumarate hydratase class I, cytosolic
— Both
C4B63_227g20 ⚠
pyruvate kinase 2
— Both
C4B63_9g333 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_16g17 ⚠
acetyl-CoA synthetase
— Both
C4B63_85g51 ⚠
fatty acyl CoA syntetase 1
— Both
C4B63_85g55 ⚠
fatty acyl CoA syntetase 1
— Both
C4B63_206g21 ⚠
fatty acyl CoA synthetase
— Both
C4B63_26g201 ⚠
cAMP specific phosphodiesterase
— Both
C4B63_38g168 ⚠
adenylosuccinate lyase
— Both
C4B63_32g236 ⚠
transketolase
— Both
C4B63_18g164 ⚠
S-adenosylmethionine synthetase
— Both
C4B63_10g290 ⚠
Paraflagellar rod protein 2
— OG7
C4B63_23g223 ⚠
cyclic nucleotide phosphodiesterase
— OG7
C4B63_13g160 ⚠
6-phosphofructo-2-kinase/fructose-2,6-bisphos
— OG7
C4B63_8g540 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG7
C4B63_23g195 ⚠
3', 5'-cyclic nucleotide phosphodiesterase
— OG7
C4B63_25g189 ⚠
3'5'-cyclic nucleotide phosphodiesterase
— OG7
C4B63_4g243 ⚠
cAMP phosphodiesterase A
— OG7
C4B63_10g291 ⚠
Paraflagellar rod protein 2
— OG7
C4B63_10g289 ⚠
Paraflagellar rod protein 2
— OG7
C4B63_25g288 ⚠
inosine-guanine nucleoside hydrolase
— Both
C4B63_10g288 ⚠
Paraflagellar rod protein 2
— OG7
C4B63_10g287 ⚠
Paraflagellar rod protein 2
— OG7
C4B63_11g491 ⚠
trypanothione synthetase
— OG7
C4B63_16g7 ⚠
trypanothione synthetase
— OG7
C4B63_9g335 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_106g1 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_314g6 ⚠
trypanothione synthetase
— OG7
C4B63_106g2 ⚠
cysteine peptidase, Clan CA, family C51
— OG7
C4B63_57g67 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_19g45 ⚠
isovaleryl-coA dehydrogenase
— Both
C4B63_8g483 ⚠
asparagine synthetase a
— Both
C4B63_2g208c ⚠
aminopeptidase P
— Both
C4B63_2g76 ⚠
aminopeptidase P
— Both
C4B63_2g77 ⚠
aminopeptidase P
— Both
C4B63_7g302 ⚠
aldose 1-epimerase-like protein
— Both
C4B63_70g63 ⚠
seryl-tRNA synthetase
— Both
C4B63_18g232 ⚠
glyceraldehyde 3-phosphate dehydrogenase
— OG6
C4B63_150g38 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_9g267 ⚠
paraflagellar rod protein 5
— Both
C4B63_26g353 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
C4B63_8g221 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.