C4B63_16g17

acetyl-CoA synthetase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100430 OG7: OG7_0000501 53 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 53 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_314g6 ⚠ trypanothione synthetase	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
C4B63_9g263 ⚠ trypanothione synthetase	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_000427 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	Both
C4B63_10g404 ⚠ guanine deaminase	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_007737 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_007737	Both
C4B63_8g483 asparagine synthetase a	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002332 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_002332	Both
C4B63_2g208c ⚠ aminopeptidase P	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001380 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001380	Both
C4B63_122g4 ⚠ UPF0160 protein C27H6.8	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_006555 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_006555	Both
C4B63_4g184 citrate synthase	—	OG6 LdBPK_180700.1 ↔ LdBPK_230580.1 OG6 LdBPK_180700.1 ↔ LdBPK_230880.1 OG7 LdBPK_180700.1 ↔ LdBPK_230580.1 OG7 LdBPK_180700.1 ↔ LdBPK_230880.1	Both
C4B63_24g215 ⚠ methyltransferase domain containing protein	—	OG7 LdBPK_230580.1 ↔ LdBPK_291030.1 OG7 LdBPK_230880.1 ↔ LdBPK_291030.1	OG7
C4B63_6g420 ⚠ Probable 28S rRNA (cytosine-C(5))-methyltrans	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
C4B63_44g246 ⚠ nucleolar protein	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
C4B63_23g124 ⚠ NOL1/NOP2/sun family	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
C4B63_7g147 ⚠ Tetratricopeptide repeat protein 39C	—	OG7 LdBPK_230580.1 ↔ LdBPK_303750.1 OG7 LdBPK_230880.1 ↔ LdBPK_303750.1	OG7
C4B63_11g99 ⚠ Putative methyltransferase NSUN6	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
C4B63_107g3 ⚠ Putative methyltransferase NSUN6	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
C4B63_9g266 ⚠ paraflagellar rod protein 5	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_000425 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	Both
C4B63_10g289 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	OG7
C4B63_106g1 ⚠ cysteine peptidase, Clan CA, family C51	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
C4B63_9g335 ⚠ cysteine peptidase, Clan CA, family C51	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
C4B63_90g46 cysteine synthase	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_008128	OG7
C4B63_10g291 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	OG7
C4B63_9g333 ⚠ cysteine peptidase, Clan CA, family C51	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
C4B63_10g287 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	OG7
C4B63_106g2 ⚠ cysteine peptidase, Clan CA, family C51	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
C4B63_10g288 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	OG7
C4B63_10g290 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	OG7
C4B63_16g7 ⚠ trypanothione synthetase	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
C4B63_11g491 ⚠ trypanothione synthetase	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
C4B63_7g165 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 LdBPK_044360.1 ↔ LdBPK_230580.1 OG6 LdBPK_044360.1 ↔ LdBPK_230880.1 OG7 LdBPK_044360.1 ↔ LdBPK_230580.1 OG7 LdBPK_044360.1 ↔ LdBPK_230880.1	Both
C4B63_286g21 ⚠ conserved hypothetical protein	—	OG6 LdBPK_230580.1 ↔ LdBPK_367300.1 OG6 LdBPK_230880.1 ↔ LdBPK_367300.1 OG7 LdBPK_230580.1 ↔ LdBPK_367300.1 OG7 LdBPK_230880.1 ↔ LdBPK_367300.1	Both
C4B63_18g180 ⚠ Tetratricopeptide repeat protein 39B	—	OG6 LdBPK_230580.1 ↔ LdBPK_303750.1 OG6 LdBPK_230880.1 ↔ LdBPK_303750.1 OG7 LdBPK_230580.1 ↔ LdBPK_303750.1 OG7 LdBPK_230880.1 ↔ LdBPK_303750.1	Both
C4B63_18g142 conserved hypothetical protein	—	OG6 LdBPK_230880.1 ↔ LdBPK_303370.1 OG7 LdBPK_230880.1 ↔ LdBPK_303370.1	Both
C4B63_9g484 ⚠ 5-methylcytosine rRNA methyltransferase NSUN4	—	OG6 LdBPK_230580.1 ↔ LdBPK_322580.1 OG6 LdBPK_230880.1 ↔ LdBPK_322580.1 OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	Both
C4B63_10g103 ⚠ Hercynine oxygenase	—	OG6 LdBPK_230580.1 ↔ LdBPK_291030.1 OG6 LdBPK_230880.1 ↔ LdBPK_291030.1 OG7 LdBPK_230580.1 ↔ LdBPK_291030.1 OG7 LdBPK_230880.1 ↔ LdBPK_291030.1	Both
C4B63_2g165 kinetoplastid kinetochore protein 2(fragment)	—	OG6 LdBPK_230880.1 ↔ LdBPK_354110.1 OG7 LdBPK_230880.1 ↔ LdBPK_354110.1	Both
C4B63_63g10 ⚠ conserved hypothetical protein	—	OG6 LdBPK_230580.1 ↔ LdBPK_367300.1 OG6 LdBPK_230880.1 ↔ LdBPK_367300.1 OG7 LdBPK_230580.1 ↔ LdBPK_367300.1 OG7 LdBPK_230880.1 ↔ LdBPK_367300.1	Both
C4B63_20g3 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 LdBPK_044360.1 ↔ LdBPK_230580.1 OG6 LdBPK_044360.1 ↔ LdBPK_230880.1 OG7 LdBPK_044360.1 ↔ LdBPK_230580.1 OG7 LdBPK_044360.1 ↔ LdBPK_230880.1	Both
C4B63_20g1 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 LdBPK_044360.1 ↔ LdBPK_230580.1 OG6 LdBPK_044360.1 ↔ LdBPK_230880.1 OG7 LdBPK_044360.1 ↔ LdBPK_230580.1 OG7 LdBPK_044360.1 ↔ LdBPK_230880.1	Both
C4B63_7g157 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 LdBPK_044360.1 ↔ LdBPK_230580.1 OG6 LdBPK_044360.1 ↔ LdBPK_230880.1 OG7 LdBPK_044360.1 ↔ LdBPK_230580.1 OG7 LdBPK_044360.1 ↔ LdBPK_230880.1	Both
C4B63_20g11 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 LdBPK_044360.1 ↔ LdBPK_230580.1 OG6 LdBPK_044360.1 ↔ LdBPK_230880.1 OG7 LdBPK_044360.1 ↔ LdBPK_230580.1 OG7 LdBPK_044360.1 ↔ LdBPK_230880.1	Both
C4B63_20g10 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 LdBPK_044360.1 ↔ LdBPK_230580.1 OG6 LdBPK_044360.1 ↔ LdBPK_230880.1 OG7 LdBPK_044360.1 ↔ LdBPK_230580.1 OG7 LdBPK_044360.1 ↔ LdBPK_230880.1	Both
C4B63_31g170 chaperone protein DNAj	—	OG6 LdBPK_080930.1 ↔ LdBPK_230880.1 OG7 LdBPK_080930.1 ↔ LdBPK_230880.1	Both
C4B63_7g173 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 LdBPK_044360.1 ↔ LdBPK_230580.1 OG6 LdBPK_044360.1 ↔ LdBPK_230880.1 OG7 LdBPK_044360.1 ↔ LdBPK_230580.1 OG7 LdBPK_044360.1 ↔ LdBPK_230880.1	Both
C4B63_7g169 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 LdBPK_044360.1 ↔ LdBPK_230580.1 OG6 LdBPK_044360.1 ↔ LdBPK_230880.1 OG7 LdBPK_044360.1 ↔ LdBPK_230580.1 OG7 LdBPK_044360.1 ↔ LdBPK_230880.1	Both
C4B63_7g161 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 LdBPK_044360.1 ↔ LdBPK_230580.1 OG6 LdBPK_044360.1 ↔ LdBPK_230880.1 OG7 LdBPK_044360.1 ↔ LdBPK_230580.1 OG7 LdBPK_044360.1 ↔ LdBPK_230880.1	Both
C4B63_20g6 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 LdBPK_044360.1 ↔ LdBPK_230580.1 OG6 LdBPK_044360.1 ↔ LdBPK_230880.1 OG7 LdBPK_044360.1 ↔ LdBPK_230580.1 OG7 LdBPK_044360.1 ↔ LdBPK_230880.1	Both
C4B63_28g107 ⚠ malic enzyme	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001501	Both
C4B63_2g77 ⚠ aminopeptidase P	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001380 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001380	Both
C4B63_275g17 ⚠ UPF0160 protein C27H6.8	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_006555 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_006555	Both
C4B63_28g106 ⚠ malic enzyme	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001501	Both
C4B63_348g24 ⚠ guanine deaminase	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_007737 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_007737	Both

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