C4B63_28g107

malic enzyme

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100205 OG7: OG7_0002857 60 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 60 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_90g46 ⚠ cysteine synthase	—	OG7 TCSYLVIO_001501 ↔ TCSYLVIO_008128	OG7
C4B63_41g203 ⚠ alanine aminotransferase	—	OG6 Tb927.1.3950 ↔ Tb927.11.5450 OG6 Tb927.1.3950 ↔ Tb927.11.5440 OG7 Tb927.1.3950 ↔ Tb927.11.5450 OG7 Tb927.1.3950 ↔ Tb927.11.5440	Both
C4B63_113g34 ⚠ ABC transporter	—	OG6 LdBPK_240780.1 ↔ LdBPK_330340.1 OG7 LdBPK_240780.1 ↔ LdBPK_330340.1	Both
C4B63_127g35 ⚠ peptidase	—	OG6 LdBPK_240780.1 ↔ LdBPK_313210.1 OG7 LdBPK_240780.1 ↔ LdBPK_313210.1	Both
C4B63_16g17 ⚠ acetyl-CoA synthetase	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001501	Both
C4B63_9g263 ⚠ trypanothione synthetase	—	OG6 TCSYLVIO_000427 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	Both
C4B63_63g46 ⚠ 2,3-bisphosphoglycerate-independent phosphogl	—	OG6 Tb927.10.7930 ↔ Tb927.11.5450 OG7 Tb927.10.7930 ↔ Tb927.11.5450	Both
C4B63_38g63 ⚠ conserved hypothetical protein	—	OG7 LdBPK_041000.1 ↔ LdBPK_240780.1	OG7
C4B63_9g333 ⚠ cysteine peptidase, Clan CA, family C51	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
C4B63_106g2 ⚠ cysteine peptidase, Clan CA, family C51	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
C4B63_314g6 ⚠ trypanothione synthetase	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
C4B63_106g1 ⚠ cysteine peptidase, Clan CA, family C51	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
C4B63_9g335 ⚠ cysteine peptidase, Clan CA, family C51	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
C4B63_16g7 ⚠ trypanothione synthetase	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
C4B63_11g491 ⚠ trypanothione synthetase	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
C4B63_41g205 ⚠ alanine aminotransferase	—	OG6 Tb927.1.3950 ↔ Tb927.11.5450 OG6 Tb927.1.3950 ↔ Tb927.11.5440 OG7 Tb927.1.3950 ↔ Tb927.11.5450 OG7 Tb927.1.3950 ↔ Tb927.11.5440	Both
C4B63_193g9 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001500 ↔ TCSYLVIO_005560	OG7
C4B63_70g129 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001500 ↔ TCSYLVIO_005560	OG7
C4B63_12g153 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001500 ↔ TCSYLVIO_005560	OG7
C4B63_10g287 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_000425 ↔ TCSYLVIO_001501	OG7
C4B63_10g288 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_000425 ↔ TCSYLVIO_001501	OG7
C4B63_10g290 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_000425 ↔ TCSYLVIO_001501	OG7
C4B63_10g289 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_000425 ↔ TCSYLVIO_001501	OG7
C4B63_10g291 ⚠ Paraflagellar rod protein 2	—	OG7 TCSYLVIO_000425 ↔ TCSYLVIO_001501	OG7
C4B63_11g18 ⚠ translation elongation factor EF-2	—	OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	OG7
C4B63_11g17 ⚠ translation elongation factor EF-2	—	OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	OG7
C4B63_9g523 ⚠ U5 small nuclear ribonucleoprotein component	—	OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	OG7
C4B63_206g11 ⚠ ABC transporter	—	OG7 LdBPK_240780.1 ↔ LdBPK_330340.1	OG7
C4B63_47g107 ⚠ ABC transporter	—	OG7 LdBPK_240780.1 ↔ LdBPK_330340.1	OG7
C4B63_4g502 ⚠ ABC transporter	—	OG7 LdBPK_240780.1 ↔ LdBPK_330340.1	OG7
C4B63_13g156 ⚠ elongation factor 2	—	OG6 Tb927.10.4560 ↔ Tb927.11.5450 OG6 Tb927.10.4560 ↔ Tb927.11.5440 OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	Both
C4B63_4g184 ⚠ citrate synthase	—	OG6 Tb927.10.13430 ↔ Tb927.11.5450 OG6 Tb927.10.13430 ↔ Tb927.11.5440 OG7 Tb927.10.13430 ↔ Tb927.11.5450 OG7 Tb927.10.13430 ↔ Tb927.11.5440	Both
C4B63_28g106 ⚠ malic enzyme	—	OG6 Tb927.11.5440 ↔ Tb927.11.5450 OG7 Tb927.11.5440 ↔ Tb927.11.5450	Both
C4B63_28g60 ⚠ fumarate hydratase	—	OG6 Tb927.11.5440 ↔ Tb927.3.4500 OG6 Tb927.11.5050 ↔ Tb927.11.5440 OG7 Tb927.11.5440 ↔ Tb927.3.4500 OG7 Tb927.11.5050 ↔ Tb927.11.5440	Both
C4B63_21g261 ⚠ isocitrate dehydrogenase [NADP], mitochondria	—	OG6 Tb927.11.5440 ↔ Tb927.8.3690 OG6 Tb927.11.5440 ↔ Tb927.11.900 OG6 Tb927.11.5450 ↔ Tb927.11.900 OG7 Tb927.11.5440 ↔ Tb927.8.3690 +2 more	Both
C4B63_23g130 ⚠ Fumarate hydratase class I, cytosolic	—	OG6 Tb927.11.5440 ↔ Tb927.3.4500 OG6 Tb927.11.5050 ↔ Tb927.11.5440 OG7 Tb927.11.5440 ↔ Tb927.3.4500 OG7 Tb927.11.5050 ↔ Tb927.11.5440	Both
C4B63_11g8 ⚠ succinyl-CoA synthetase alpha subunit	—	OG6 Tb927.11.5450 ↔ Tb927.3.2230 OG7 Tb927.11.5450 ↔ Tb927.3.2230	Both
C4B63_2g752 ⚠ 6-phosphogluconate dehydrogenase, decarboxyla	—	OG6 Tb927.11.5440 ↔ Tb927.9.12110 OG6 Tb927.11.5450 ↔ Tb927.9.12110 OG7 Tb927.11.5440 ↔ Tb927.9.12110 OG7 Tb927.11.5450 ↔ Tb927.9.12110	Both
C4B63_47g72 ⚠ enolase	—	OG6 Tb927.10.2890 ↔ Tb927.11.5450 OG6 Tb927.10.2890 ↔ Tb927.11.5440 OG7 Tb927.10.2890 ↔ Tb927.11.5450 OG7 Tb927.10.2890 ↔ Tb927.11.5440	Both
C4B63_2g77 ⚠ aminopeptidase P	—	OG6 TCSYLVIO_001380 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_001380 ↔ TCSYLVIO_001501	Both
C4B63_2g76 ⚠ aminopeptidase P	—	OG6 TCSYLVIO_001380 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_001380 ↔ TCSYLVIO_001501	Both
C4B63_2g208c ⚠ aminopeptidase P	—	OG6 TCSYLVIO_001380 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_001380 ↔ TCSYLVIO_001501	Both
C4B63_13g152 ⚠ elongation factor 2	—	OG6 Tb927.10.4560 ↔ Tb927.11.5450 OG6 Tb927.10.4560 ↔ Tb927.11.5440 OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	Both
C4B63_13g157 ⚠ elongation factor 2	—	OG6 Tb927.10.4560 ↔ Tb927.11.5450 OG6 Tb927.10.4560 ↔ Tb927.11.5440 OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	Both
C4B63_13g153 ⚠ elongation factor 2	—	OG6 Tb927.10.4560 ↔ Tb927.11.5450 OG6 Tb927.10.4560 ↔ Tb927.11.5440 OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	Both
C4B63_19g185 ⚠ isocitrate dehydrogenase	—	OG6 Tb927.11.5440 ↔ Tb927.8.3690 OG6 Tb927.11.5440 ↔ Tb927.11.900 OG6 Tb927.11.5450 ↔ Tb927.11.900 OG7 Tb927.11.5440 ↔ Tb927.8.3690 +2 more	Both
C4B63_13g155 ⚠ elongation factor 2	—	OG6 Tb927.10.4560 ↔ Tb927.11.5450 OG6 Tb927.10.4560 ↔ Tb927.11.5440 OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	Both
C4B63_13g154 ⚠ elongation factor 2	—	OG6 Tb927.10.4560 ↔ Tb927.11.5450 OG6 Tb927.10.4560 ↔ Tb927.11.5440 OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	Both
C4B63_9g267 ⚠ paraflagellar rod protein 5	—	OG6 TCSYLVIO_000425 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000425 ↔ TCSYLVIO_001501	Both
C4B63_9g266 ⚠ paraflagellar rod protein 5	—	OG6 TCSYLVIO_000425 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000425 ↔ TCSYLVIO_001501	Both

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