C4B63_47g72

enolase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100260 OG7: OG7_0002539 63 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 63 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_47g40 ⚠ CS domain containing protein	—	OG6 TCSYLVIO_004545 ↔ TCSYLVIO_005716 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_005716	Both
C4B63_20g10 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 TCSYLVIO_003910 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_003911 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_004545 ↔ TCSYLVIO_009589 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_009589 +2 more	Both
C4B63_7g165 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 TCSYLVIO_003910 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_003911 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_004545 ↔ TCSYLVIO_009589 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_009589 +2 more	Both
C4B63_7g173 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 TCSYLVIO_003910 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_003911 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_004545 ↔ TCSYLVIO_009589 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_009589 +2 more	Both
C4B63_7g169 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 TCSYLVIO_003910 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_003911 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_004545 ↔ TCSYLVIO_009589 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_009589 +2 more	Both
C4B63_7g161 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 TCSYLVIO_003910 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_003911 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_004545 ↔ TCSYLVIO_009589 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_009589 +2 more	Both
C4B63_20g6 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 TCSYLVIO_003910 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_003911 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_004545 ↔ TCSYLVIO_009589 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_009589 +2 more	Both
C4B63_4g324 aconitase	—	OG6 Tb927.10.14000 ↔ Tb927.10.2890 OG7 Tb927.10.14000 ↔ Tb927.10.2890	Both
C4B63_14g241 ⚠ trypanothione reductase	—	OG6 Tb927.10.10390 ↔ Tb927.10.2890 OG7 Tb927.10.10390 ↔ Tb927.10.2890	Both
C4B63_303g16 ⚠ trypanothione reductase	—	OG6 Tb927.10.10390 ↔ Tb927.10.2890 OG7 Tb927.10.10390 ↔ Tb927.10.2890	Both
C4B63_23g212 ⚠ serine/threonine-protein kinase	—	OG6 TCSYLVIO_004423 ↔ TCSYLVIO_004545	OG6
C4B63_23g211 ⚠ protein kinase(fragment)	—	OG6 TCSYLVIO_004423 ↔ TCSYLVIO_004545	OG6
C4B63_32g236 transketolase	—	OG6 TCSYLVIO_001301 ↔ TCSYLVIO_004545 OG7 TCSYLVIO_001301 ↔ TCSYLVIO_004545	Both
C4B63_63g46 2,3-bisphosphoglycerate-independent phosphogl	—	OG6 TCSYLVIO_004545 ↔ TCSYLVIO_004608 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_004608	Both
C4B63_81g92 phosphomannomutase	—	OG6 TCSYLVIO_004545 ↔ TCSYLVIO_004975 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_004975	Both
C4B63_11g262 ⚠ gamma-glutamylcysteine synthetase	—	OG6 TCSYLVIO_004545 ↔ TCSYLVIO_006303 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_006303	Both
C4B63_20g11 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 TCSYLVIO_003910 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_003911 ↔ TCSYLVIO_004545 OG6 TCSYLVIO_004545 ↔ TCSYLVIO_009589 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_009589 +2 more	Both
C4B63_2g235 ⚠ Co-chaperone protein P23	—	OG6 TCSYLVIO_004545 ↔ TCSYLVIO_005716 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_005716	Both
C4B63_116g18 ⚠ gamma-glutamylcysteine synthetase	—	OG6 TCSYLVIO_004545 ↔ TCSYLVIO_006303 OG7 TCSYLVIO_004545 ↔ TCSYLVIO_006303	Both
C4B63_41g205 ⚠ alanine aminotransferase	—	OG6 Tb927.1.3950 ↔ Tb927.10.2890 OG7 Tb927.1.3950 ↔ Tb927.10.2890	Both
C4B63_41g203 ⚠ alanine aminotransferase	—	OG6 Tb927.1.3950 ↔ Tb927.10.2890 OG7 Tb927.1.3950 ↔ Tb927.10.2890	Both
C4B63_30g290 mercaptopyruvate sulfurtransferase	—	OG6 TCSYLVIO_001928 ↔ TCSYLVIO_004545 OG7 TCSYLVIO_001928 ↔ TCSYLVIO_004545	Both
C4B63_114g23 UBX domain-containing protein 3	—	OG6 TCSYLVIO_001163 ↔ TCSYLVIO_004545 OG7 TCSYLVIO_001163 ↔ TCSYLVIO_004545	Both
C4B63_22g59 cytidine triphosphate synthase	—	OG6 Tb927.1.1240 ↔ Tb927.10.2890 OG7 Tb927.1.1240 ↔ Tb927.10.2890	Both
C4B63_41g245 ⚠ puromycin-sensitive aminopeptidase-like prote	—	OG7 Tb927.10.2890 ↔ Tb927.3.4750	OG7
C4B63_170g15 ⚠ aminopeptidase	—	OG7 Tb927.10.2890 ↔ Tb927.3.4750	OG7
C4B63_11g18 ⚠ translation elongation factor EF-2	—	OG7 Tb927.10.2890 ↔ Tb927.10.4560	OG7
C4B63_11g17 ⚠ translation elongation factor EF-2	—	OG7 Tb927.10.2890 ↔ Tb927.10.4560	OG7
C4B63_87g24 ⚠ nonspecific lipid-transfer protein	—	OG7 Tb927.10.2890 ↔ Tb927.8.2540	OG7
C4B63_46g74 ⚠ aminopeptidase	—	OG7 Tb927.10.2890 ↔ Tb927.3.4750	OG7
C4B63_41g246 ⚠ puromycin-sensitive aminopeptidase-like prote	—	OG7 Tb927.10.2890 ↔ Tb927.3.4750	OG7
C4B63_9g523 ⚠ U5 small nuclear ribonucleoprotein component	—	OG7 Tb927.10.2890 ↔ Tb927.10.4560	OG7
C4B63_32g225 3-hydroxy-3-methylglutaryl-CoA synthase	—	OG6 Tb927.10.2890 ↔ Tb927.8.6110 OG7 Tb927.10.2890 ↔ Tb927.8.6110	Both
C4B63_28g107 ⚠ malic enzyme	—	OG6 Tb927.10.2890 ↔ Tb927.11.5450 OG6 Tb927.10.2890 ↔ Tb927.11.5440 OG7 Tb927.10.2890 ↔ Tb927.11.5450 OG7 Tb927.10.2890 ↔ Tb927.11.5440	Both
C4B63_19g185 ⚠ isocitrate dehydrogenase	—	OG6 Tb927.10.2890 ↔ Tb927.11.900 OG7 Tb927.10.2890 ↔ Tb927.11.900	Both
C4B63_147g45 ⚠ kynureninase	—	OG6 Tb927.10.2890 ↔ Tb927.9.2010 OG7 Tb927.10.2890 ↔ Tb927.9.2010	Both
C4B63_60g116 ⚠ aspartate carbamoyltransferase	—	OG6 Tb927.10.2890 ↔ Tb927.5.3820 OG7 Tb927.10.2890 ↔ Tb927.5.3820	Both
C4B63_28g60 ⚠ fumarate hydratase	—	OG6 Tb927.10.2890 ↔ Tb927.11.5050 OG6 Tb927.10.2890 ↔ Tb927.3.4500 OG7 Tb927.10.2890 ↔ Tb927.11.5050 OG7 Tb927.10.2890 ↔ Tb927.3.4500	Both
C4B63_28g106 ⚠ malic enzyme	—	OG6 Tb927.10.2890 ↔ Tb927.11.5450 OG6 Tb927.10.2890 ↔ Tb927.11.5440 OG7 Tb927.10.2890 ↔ Tb927.11.5450 OG7 Tb927.10.2890 ↔ Tb927.11.5440	Both
C4B63_13g152 ⚠ elongation factor 2	—	OG6 Tb927.10.2890 ↔ Tb927.10.4560 OG7 Tb927.10.2890 ↔ Tb927.10.4560	Both
C4B63_13g157 ⚠ elongation factor 2	—	OG6 Tb927.10.2890 ↔ Tb927.10.4560 OG7 Tb927.10.2890 ↔ Tb927.10.4560	Both
C4B63_13g153 ⚠ elongation factor 2	—	OG6 Tb927.10.2890 ↔ Tb927.10.4560 OG7 Tb927.10.2890 ↔ Tb927.10.4560	Both
C4B63_16g302 ⚠ 3-ketoacyl-CoA thiolase	—	OG6 Tb927.10.2890 ↔ Tb927.8.2540 OG7 Tb927.10.2890 ↔ Tb927.8.2540	Both
C4B63_21g261 ⚠ isocitrate dehydrogenase [NADP], mitochondria	—	OG6 Tb927.10.2890 ↔ Tb927.11.900 OG7 Tb927.10.2890 ↔ Tb927.11.900	Both
C4B63_2g784 glycerol kinase, glycosomal	—	OG6 Tb927.10.2890 ↔ Tb927.9.12570 OG7 Tb927.10.2890 ↔ Tb927.9.12570	Both
C4B63_23g130 ⚠ Fumarate hydratase class I, cytosolic	—	OG6 Tb927.10.2890 ↔ Tb927.11.5050 OG6 Tb927.10.2890 ↔ Tb927.3.4500 OG7 Tb927.10.2890 ↔ Tb927.11.5050 OG7 Tb927.10.2890 ↔ Tb927.3.4500	Both
C4B63_31g264 ⚠ aspartate carbamoyltransferase	—	OG6 Tb927.10.2890 ↔ Tb927.5.3820 OG7 Tb927.10.2890 ↔ Tb927.5.3820	Both
C4B63_80g21 Nucleoside diphosphate kinase	—	OG6 Tb927.10.2890 ↔ Tb927.11.16130 OG7 Tb927.10.2890 ↔ Tb927.11.16130	Both
C4B63_4g184 citrate synthase	—	OG6 Tb927.10.13430 ↔ Tb927.10.2890 OG7 Tb927.10.13430 ↔ Tb927.10.2890	Both
C4B63_35g155 ⚠ aspartate carbamoyltransferase	—	OG6 Tb927.10.2890 ↔ Tb927.5.3820 OG7 Tb927.10.2890 ↔ Tb927.5.3820	Both

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