C4B63_306g12

glucose-6-phosphate 1-dehydrogenase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100726 OG7: OG7_0003663 31 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 31 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_63g19 ⚠ Bromodomain factor 1	—	OG7 TCSYLVIO_004401 ↔ TCSYLVIO_005041 OG7 TCSYLVIO_004400 ↔ TCSYLVIO_005041 OG7 TCSYLVIO_004398 ↔ TCSYLVIO_005041 OG7 Tb927.10.2490 ↔ Tb927.10.7420	OG7
C4B63_40g26 ⚠ bromodomain-containing protein 3	—	OG7 TCSYLVIO_004401 ↔ TCSYLVIO_005041 OG7 TCSYLVIO_004400 ↔ TCSYLVIO_005041 OG7 TCSYLVIO_004398 ↔ TCSYLVIO_005041 OG7 Tb927.10.2490 ↔ Tb927.10.7420	OG7
C4B63_57g96 ⚠ bromodomain protein	—	OG6 TCSYLVIO_004401 ↔ TCSYLVIO_005041 OG6 TCSYLVIO_004400 ↔ TCSYLVIO_005041 OG6 TCSYLVIO_004398 ↔ TCSYLVIO_005041 OG6 Tb927.10.2490 ↔ Tb927.10.7420 +4 more	Both
C4B63_149g26 ⚠ GDP-mannose pyrophosphorylase	—	OG6 Tb927.10.2490 ↔ Tb927.8.2050 OG7 Tb927.10.2490 ↔ Tb927.8.2050	Both
C4B63_18g130 ⚠ glutamyl-tRNA synthetase	—	OG7 Tb927.10.2490 ↔ Tb927.9.5210	OG7
C4B63_58g52 ⚠ conserved hypothetical protein	—	OG6 Tb927.10.1930 ↔ Tb927.10.2490 OG7 Tb927.10.1930 ↔ Tb927.10.2490	Both
C4B63_58g53 ⚠ conserved hypothetical protein	—	OG6 Tb927.10.1930 ↔ Tb927.10.2490 OG7 Tb927.10.1930 ↔ Tb927.10.2490	Both
C4B63_26g206 ⚠ glutaminyl-tRNA synthetase	—	OG6 Tb927.10.2490 ↔ Tb927.9.5210 OG7 Tb927.10.2490 ↔ Tb927.9.5210	Both
C4B63_7g302 ⚠ aldose 1-epimerase-like protein	—	OG6 Tb927.10.2490 ↔ Tb927.4.1360 OG7 Tb927.10.2490 ↔ Tb927.4.1360	Both
C4B63_48g118 ⚠ aldehyde dehydrogenase	—	OG6 Tb927.10.2490 ↔ Tb927.10.6190 OG7 Tb927.10.2490 ↔ Tb927.10.6190	Both
C4B63_30g161 ⚠ glutamine synthetase	—	OG6 Tb927.10.2490 ↔ Tb927.7.4970 OG7 Tb927.10.2490 ↔ Tb927.7.4970	Both
C4B63_39g336 ⚠ S-adenosylhomocysteine hydrolase	—	OG6 Tb927.10.2490 ↔ Tb927.11.9590 OG7 Tb927.10.2490 ↔ Tb927.11.9590	Both
C4B63_101g36 ⚠ inositol-3-phosphate synthase	—	OG6 Tb927.10.2490 ↔ Tb927.10.7110 OG7 Tb927.10.2490 ↔ Tb927.10.7110	Both
C4B63_12g220 ⚠ pyruvate phosphate dikinase	—	OG6 Tb927.10.2490 ↔ Tb927.11.6280 OG7 Tb927.10.2490 ↔ Tb927.11.6280	Both
C4B63_19g45 ⚠ isovaleryl-coA dehydrogenase	—	OG6 Tb927.10.2490 ↔ Tb927.11.1540 OG7 Tb927.10.2490 ↔ Tb927.11.1540	Both
C4B63_355g19 ⚠ inositol-3-phosphate synthase(fragment)	—	OG6 Tb927.10.2490 ↔ Tb927.10.7110 OG7 Tb927.10.2490 ↔ Tb927.10.7110	Both
C4B63_12g221 ⚠ pyruvate phosphate dikinase	—	OG6 Tb927.10.2490 ↔ Tb927.11.6280 OG7 Tb927.10.2490 ↔ Tb927.11.6280	Both
C4B63_47g24 ⚠ Glucose-6-phosphate dehydrogenase	—	OG6 TCSYLVIO_004400 ↔ TCSYLVIO_004401 OG6 TCSYLVIO_004398 ↔ TCSYLVIO_004401 OG6 TCSYLVIO_004398 ↔ TCSYLVIO_004400 OG7 TCSYLVIO_004400 ↔ TCSYLVIO_004401 +2 more	Both
C4B63_143g20 ⚠ glutamine synthetase	—	OG6 Tb927.10.2490 ↔ Tb927.7.4970 OG7 Tb927.10.2490 ↔ Tb927.7.4970	Both
C4B63_21g68 ⚠ small GTP-binding protein Rab11	—	OG6 TCSYLVIO_000260 ↔ TCSYLVIO_004398 OG6 TCSYLVIO_000260 ↔ TCSYLVIO_004401 OG6 TCSYLVIO_000260 ↔ TCSYLVIO_004400	OG6
C4B63_13g271 ⚠ fructose-bisphosphate aldolase, glycosomal	—	OG6 LdBPK_340080.1 ↔ LdBPK_361320.1 OG7 LdBPK_340080.1 ↔ LdBPK_361320.1	Both
C4B63_13g270 ⚠ fructose-bisphosphate aldolase, glycosomal	—	OG6 LdBPK_340080.1 ↔ LdBPK_361320.1 OG7 LdBPK_340080.1 ↔ LdBPK_361320.1	Both
C4B63_31g266 ⚠ succinate dehydrogenase subunit	—	OG6 TCSYLVIO_001185 ↔ TCSYLVIO_004398 OG6 TCSYLVIO_001185 ↔ TCSYLVIO_004401 OG6 TCSYLVIO_001185 ↔ TCSYLVIO_004400 OG7 TCSYLVIO_001185 ↔ TCSYLVIO_004398 +2 more	Both
C4B63_60g118 ⚠ succinate dehydrogenase subunit	—	OG6 TCSYLVIO_001185 ↔ TCSYLVIO_004398 OG6 TCSYLVIO_001185 ↔ TCSYLVIO_004401 OG6 TCSYLVIO_001185 ↔ TCSYLVIO_004400 OG7 TCSYLVIO_001185 ↔ TCSYLVIO_004398 +2 more	Both
C4B63_134g62 ⚠ succinate dehydrogenase subunit	—	OG6 TCSYLVIO_001185 ↔ TCSYLVIO_004398 OG6 TCSYLVIO_001185 ↔ TCSYLVIO_004401 OG6 TCSYLVIO_001185 ↔ TCSYLVIO_004400 OG7 TCSYLVIO_001185 ↔ TCSYLVIO_004398 +2 more	Both
C4B63_35g157 ⚠ succinate dehydrogenase subunit	—	OG6 TCSYLVIO_001185 ↔ TCSYLVIO_004398 OG6 TCSYLVIO_001185 ↔ TCSYLVIO_004401 OG6 TCSYLVIO_001185 ↔ TCSYLVIO_004400 OG7 TCSYLVIO_001185 ↔ TCSYLVIO_004398 +2 more	Both
C4B63_7g202 ⚠ Coiled-coil and C2 domain-containing protein	—	OG6 TCSYLVIO_003850 ↔ TCSYLVIO_004398 OG6 TCSYLVIO_003850 ↔ TCSYLVIO_004401 OG6 TCSYLVIO_003850 ↔ TCSYLVIO_004400 OG7 TCSYLVIO_003850 ↔ TCSYLVIO_004398 +2 more	Both
C4B63_116g14 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004401 ↔ TCSYLVIO_006299 OG6 TCSYLVIO_004400 ↔ TCSYLVIO_006299 OG6 TCSYLVIO_004398 ↔ TCSYLVIO_006299 OG7 TCSYLVIO_004401 ↔ TCSYLVIO_006299 +2 more	Both
C4B63_3g1120 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004401 ↔ TCSYLVIO_007761 OG6 TCSYLVIO_004400 ↔ TCSYLVIO_007761 OG6 TCSYLVIO_004398 ↔ TCSYLVIO_007761 OG7 TCSYLVIO_004401 ↔ TCSYLVIO_007761 +2 more	Both
C4B63_98g4 ⚠ glucose-6-phosphate 1-dehydrogenase	—	OG6 TCSYLVIO_004400 ↔ TCSYLVIO_004401 OG6 TCSYLVIO_004398 ↔ TCSYLVIO_004401 OG6 TCSYLVIO_004398 ↔ TCSYLVIO_004400 OG7 TCSYLVIO_004400 ↔ TCSYLVIO_004401 +2 more	Both
C4B63_135g22 ⚠ Glucose-6-phosphate dehydrogenase	—	OG6 TCSYLVIO_004400 ↔ TCSYLVIO_004401 OG6 TCSYLVIO_004398 ↔ TCSYLVIO_004401 OG6 TCSYLVIO_004398 ↔ TCSYLVIO_004400 OG7 TCSYLVIO_004400 ↔ TCSYLVIO_004401 +2 more	Both