C4B63_22g161

calpain-like cysteine peptidase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_127587 OG7: OG7_0001161 156 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 156 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_193g9 ⚠
metallo-peptidase, Clan MF, Family M17
— OG6
C4B63_70g129 ⚠
metallo-peptidase, Clan MF, Family M17
— OG6
C4B63_12g153 ⚠
metallo-peptidase, Clan MF, Family M17
— OG6
C4B63_31g76 ⚠
ubiquitin-activating enzyme
— OG6
C4B63_70g77 ⚠
acidocalcisomal pyrophosphatase
— OG6
C4B63_23g248 ⚠
inorganic pyrophosphatase
— OG6
C4B63_2g799 ⚠
tRNA wybutosine-synthesizing protein 4
— OG6
C4B63_85g64 ⚠
DNA-damage inducible protein DDI1-like protei
— OG6
C4B63_153g41 ⚠
inositol 5-phosphatase 1(fragment)
— OG6
C4B63_2g513 ⚠
conserved hypothetical protein
— OG6
C4B63_2g748 ⚠
conserved hypothetical protein
— OG6
C4B63_8g540 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG6
C4B63_7g347 ⚠
V-type ATPase, A subunit
— OG6
C4B63_4g269 ⚠
conserved hypothetical protein
— OG6
C4B63_11g32 ⚠
conserved hypothetical protein
— OG6
C4B63_2g376 ⚠
ribosome assembly protein RRB1
— OG6
C4B63_51g174 ⚠
Flagellar radial spoke protein 4/6
— OG6
C4B63_42g49 ⚠
Protein aardvark
— OG6
C4B63_80g25 ⚠
ubiquitin hydrolase
— OG6
C4B63_4g477 ⚠
Probable ATP-dependent RNA helicase DHX35
— OG6
C4B63_2g750 ⚠
death-receptor fusion protein (DUF2428)
— OG6
C4B63_14g80 ⚠
conserved hypothetical protein
— OG6
C4B63_13g240 ⚠
conserved hypothetical protein
— OG6
C4B63_137g49 ⚠
conserved hypothetical protein
— OG6
C4B63_259g15 ⚠
Paladin
— OG6
C4B63_9g251 ⚠
cdc2-related kinase 9
— OG6
C4B63_14g79 ⚠
conserved hypothetical protein
— OG6
C4B63_14g81 ⚠
conserved hypothetical protein
— OG6
C4B63_6g322 ⚠
conserved hypothetical protein
— OG6
C4B63_28g57 ⚠
E3 ubiquitin-protein ligase listerin
— OG6
C4B63_16g140 ⚠
Paladin
— OG6
C4B63_14g93 ⚠
Cyclin 12, L-type
— OG6
C4B63_6g104 ⚠
mitochondrial RNA binding protein
— OG6
C4B63_28g171 ⚠
RNA-binding protein 38
— OG6
C4B63_18g263 ⚠
SPA/DENN domain containing protein
— OG6
C4B63_33g8 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— OG6
C4B63_76g41 ⚠
Probable S-adenosyl-L-methionine-binding prot
— OG6
C4B63_29g3 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— OG6
C4B63_56g104 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— OG6
C4B63_44g120 ⚠
conserved hypothetical protein
— OG6
C4B63_83g73 ⚠
ribonucleoprotein p18, mitochondrial precurso
— OG6
C4B63_28g27 ⚠
clathrin coat assembly protein
— OG6
C4B63_4g146 ⚠
pyruvate kinase 2
— OG6
C4B63_42g202 ⚠
aspartyl-tRNA synthetase
— OG6
C4B63_54g57 ⚠
vacuolar ATP synthase subunit d
— OG6
C4B63_11g484 ⚠
Leucine Rich Repeat protein
— OG6
C4B63_168g16 ⚠
aspartyl-tRNA synthetase
— OG6
C4B63_42g203 ⚠
aspartyl-tRNA synthetase
— OG6
C4B63_11g100 ⚠
Rab3 GTPase-activating protein catalytic subu
— OG6
C4B63_21g30 ⚠
Exportin-7-A
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.