C4B63_16g140

Paladin
Trypanosoma cruzi Dm28c 2018 OG6: OG6_105409 OG7: OG7_0009012 52 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 52 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_6g592 ⚠
pumilio/PUF RNA binding protein 5
— OG7
C4B63_14g93 ⚠
Cyclin 12, L-type
— Both
C4B63_2g799 ⚠
tRNA wybutosine-synthesizing protein 4
— Both
C4B63_6g104 ⚠
mitochondrial RNA binding protein
— Both
C4B63_28g171 ⚠
RNA-binding protein 38
— Both
C4B63_18g263 ⚠
SPA/DENN domain containing protein
— Both
C4B63_28g87 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG7
C4B63_23g33 ⚠
conserved hypothetical protein
— OG7
C4B63_58g121 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_42g96 ⚠
ubiquitin hydrolase
— OG7
C4B63_30g224 ⚠
conserved hypothetical protein
— OG7
C4B63_413g14 ⚠
pumilio/PUF RNA binding protein 4
— OG7
C4B63_22g175 ⚠
pumilio/PUF RNA binding protein 9
— OG7
C4B63_28g57 ⚠
E3 ubiquitin-protein ligase listerin
— Both
C4B63_204g19 ⚠
pumilio/PUF RNA binding protein 6
— OG7
C4B63_41g148 ⚠
pumilio/PUF RNA binding protein 4
— OG7
C4B63_439g12 ⚠
pumilio/PUF RNA binding protein 4
— OG7
C4B63_13g170 ⚠
pumilio/PUF RNA binding protein 1
— OG7
C4B63_97g23 ⚠
pumilio/PUF RNA binding protein 2
— OG7
C4B63_43g137 ⚠
pumilio/PUF RNA binding protein 3
— OG7
C4B63_13g295 ⚠
pumilio/PUF RNA binding protein 6
— OG7
C4B63_13g166 ⚠
leucine carboxyl methyltransferase
— OG7
C4B63_18g1175c ⚠
conserved hypothetical protein
— OG7
C4B63_44g125 ⚠
conserved hypothetical protein
— OG7
C4B63_18g1166c ⚠
conserved hypothetical protein
— OG7
C4B63_17g55 ⚠
cyclin 9
— OG7
C4B63_22g164 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_23g2 ⚠
conserved hypothetical protein
— Both
C4B63_156g8 ⚠
conserved hypothetical protein
— Both
C4B63_323g8 ⚠
conserved hypothetical protein
— Both
C4B63_23g32 ⚠
conserved hypothetical protein
— Both
C4B63_27g222 ⚠
leucine-rich repeat protein(fragment)
— Both
C4B63_27g221 ⚠
leucine-rich repeat protein
— Both
C4B63_4g477 ⚠
Probable ATP-dependent RNA helicase DHX35
— Both
C4B63_4g246 ⚠
AN1-type zinc finger protein 2B
— Both
C4B63_199g2 ⚠
conserved hypothetical protein
— Both
C4B63_199g1 ⚠
conserved hypothetical protein
— Both
C4B63_21g285 ⚠
conserved hypothetical protein
— Both
C4B63_21g284 ⚠
conserved hypothetical protein
— Both
C4B63_23g1 ⚠
conserved hypothetical protein
— Both
C4B63_38g169 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_22g161 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_35g128 ⚠
ubiquitin hydrolase
— Both
C4B63_134g35 ⚠
ubiquitin hydrolase
— Both
C4B63_2g750 ⚠
death-receptor fusion protein (DUF2428)
— Both
C4B63_14g80 ⚠
conserved hypothetical protein
— Both
C4B63_137g49 ⚠
conserved hypothetical protein
— Both
C4B63_9g251 ⚠
cdc2-related kinase 9
— OG6
C4B63_14g79 ⚠
conserved hypothetical protein
— Both
C4B63_18g50 ⚠
microtubule associated protein xmap215
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.