C4B63_14g188

UPF0769 protein C21orf59 homolog B

Trypanosoma cruzi Dm28c 2018 OG6: OG6_104560 OG7: OG7_0009458 214 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 214 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_10g148 ⚠ carnitine/choline acetyltransferase	—	OG6 TCSYLVIO_004300 ↔ TCSYLVIO_004765	OG6
C4B63_23g248 ⚠ inorganic pyrophosphatase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_004765	Both
C4B63_9g331 ⚠ transcription elongation factor s-II	—	OG6 TCSYLVIO_000382 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_000382 ↔ TCSYLVIO_004765	Both
C4B63_112g17 conserved hypothetical protein	—	OG6 TCSYLVIO_001734 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_001734 ↔ TCSYLVIO_004765	Both
C4B63_47g80 Gamma-soluble NSF attachment protein	—	OG6 TCSYLVIO_004539 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004539 ↔ TCSYLVIO_004765	Both
C4B63_279g8 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG6 TCSYLVIO_002972 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_002972 ↔ TCSYLVIO_004765	Both
C4B63_44g252 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG6 TCSYLVIO_002972 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_002972 ↔ TCSYLVIO_004765	Both
C4B63_69g27 35 kDa cyclophilin	—	OG6 TCSYLVIO_003462 ↔ TCSYLVIO_004765	OG6
C4B63_14g35 Sucrase/ferredoxin-like	—	OG6 TCSYLVIO_004651 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004651 ↔ TCSYLVIO_004765	Both
C4B63_230g26 ⚠ tRNA threonylcarbamoyl adenosine modification	—	OG6 TCSYLVIO_002651 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_002651 ↔ TCSYLVIO_004765	Both
C4B63_6g385 ⚠ tRNA threonylcarbamoyl adenosine modification	—	OG6 TCSYLVIO_002651 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_002651 ↔ TCSYLVIO_004765	Both
C4B63_23g200 Flagellum attachment zone protein 19	—	OG6 TCSYLVIO_004414 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004414 ↔ TCSYLVIO_004765	Both
C4B63_60g172 conserved hypothetical protein	—	OG6 TCSYLVIO_001224 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_001224 ↔ TCSYLVIO_004765	Both
C4B63_114g23 UBX domain-containing protein 3	—	OG6 TCSYLVIO_001163 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_001163 ↔ TCSYLVIO_004765	Both
C4B63_16g163 Pyridoxal phosphate homeostasis protein	—	OG6 TCSYLVIO_000216 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_000216 ↔ TCSYLVIO_004765	Both
C4B63_30g145 electron-transfer-flavoprotein, alpha polypep	—	OG6 TCSYLVIO_001784 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_001784 ↔ TCSYLVIO_004765	Both
C4B63_42g217 protein phosphatase	—	OG6 TCSYLVIO_003097 ↔ TCSYLVIO_004765	OG6
C4B63_30g144 Cilia- and flagella-associated protein 52	—	OG6 TCSYLVIO_001783 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_001783 ↔ TCSYLVIO_004765	Both
C4B63_17g188 ⚠ Phosphopantetheine adenylyltransferase	—	OG6 TCSYLVIO_004096 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004096 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004765 ↔ TCSYLVIO_006158	Both
C4B63_7g361 phosphomannomutase-like protein	—	OG6 TCSYLVIO_003734 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_003734 ↔ TCSYLVIO_004765	Both
C4B63_184g8 ⚠ GTP-binding protein	—	OG6 TCSYLVIO_000468 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_000468 ↔ TCSYLVIO_004765	Both
C4B63_9g201 ⚠ GTP-binding protein	—	OG6 TCSYLVIO_000468 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_000468 ↔ TCSYLVIO_004765	Both
C4B63_17g99 exportin 1	—	OG6 TCSYLVIO_004194 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004194 ↔ TCSYLVIO_004765	Both
C4B63_297g19 ⚠ Protein phosphatase methylesterase 1	—	OG6 TCSYLVIO_004210 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004210 ↔ TCSYLVIO_004765	Both
C4B63_18g30 ⚠ epsilon-adaptin	—	OG6 TCSYLVIO_003203 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_003203 ↔ TCSYLVIO_004765	Both
C4B63_17g73 ⚠ Probable protein phosphatase methylesterase 1	—	OG6 TCSYLVIO_004210 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004210 ↔ TCSYLVIO_004765	Both
C4B63_10g147 ⚠ carnitine O-acetyltransferase(fragment)	—	OG6 TCSYLVIO_004300 ↔ TCSYLVIO_004765	OG6
C4B63_6g572 ⚠ 5'-3' exoribonuclease A	—	OG6 TCSYLVIO_002495 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_002495 ↔ TCSYLVIO_004765	Both
C4B63_55g68 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001023 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_001023 ↔ TCSYLVIO_004765	Both
C4B63_55g69 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001023 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_001023 ↔ TCSYLVIO_004765	Both
C4B63_238g18 ⚠ GMP synthase(fragment)	—	OG6 TCSYLVIO_001147 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_001147 ↔ TCSYLVIO_004765	Both
C4B63_142g6 ⚠ GMP synthase	—	OG6 TCSYLVIO_001147 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_001147 ↔ TCSYLVIO_004765	Both
C4B63_42g174 conserved hypothetical protein	—	OG6 TCSYLVIO_003130 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_003130 ↔ TCSYLVIO_004765	Both
C4B63_18g152 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_003372 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_003372 ↔ TCSYLVIO_004765	Both
C4B63_14g25 ⚠ small G-protein	—	OG6 TCSYLVIO_004644 ↔ TCSYLVIO_004765	OG6
C4B63_18g151 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_003372 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_003372 ↔ TCSYLVIO_004765	Both
C4B63_14g17 ⚠ small G-protein	—	OG6 TCSYLVIO_004644 ↔ TCSYLVIO_004765	OG6
C4B63_63g47 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004609 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004609 ↔ TCSYLVIO_004765	Both
C4B63_63g46 2,3-bisphosphoglycerate-independent phosphogl	—	OG6 TCSYLVIO_004608 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004608 ↔ TCSYLVIO_004765	Both
C4B63_23g34 quinone oxidoreductase	—	OG6 TCSYLVIO_004489 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004489 ↔ TCSYLVIO_004765	Both
C4B63_35g125 transaldolase	—	OG6 TCSYLVIO_001112 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_001112 ↔ TCSYLVIO_004765	Both
C4B63_9g488 conserved hypothetical protein	—	OG6 TCSYLVIO_004051 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004051 ↔ TCSYLVIO_004765	Both
C4B63_6g148 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 TCSYLVIO_002576 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_002576 ↔ TCSYLVIO_004765	Both
C4B63_28g64 ⚠ aspartate aminotransferase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_004765	Both
C4B63_6g146 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 TCSYLVIO_002576 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_002576 ↔ TCSYLVIO_004765	Both
C4B63_54g69 ⚠ aspartate aminotransferase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_004765	Both
C4B63_253g15 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 TCSYLVIO_002576 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_002576 ↔ TCSYLVIO_004765	Both
C4B63_18g278 RNA-binding protein	—	OG6 TCSYLVIO_003292 ↔ TCSYLVIO_004765	OG6
C4B63_48g116 ⚠ 5'-3' exoribonuclease D	—	OG6 TCSYLVIO_002495 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_002495 ↔ TCSYLVIO_004765	Both
C4B63_3g494 ⚠ Mucin-associated surface protein (MASP)	—	OG6 TCSYLVIO_002495 ↔ TCSYLVIO_004765	OG6

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