C4B63_55g26

conserved hypothetical protein

Trypanosoma cruzi Dm28c 2018 OG6: OG6_148250 OG7: OG7_0051961 210 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 210 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_14g782c ⚠ monothiol glutaredoxin	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_007499 OG6 Tb927.5.950 ↔ Tb927.8.4930 OG7 Tb927.5.950 ↔ Tb927.8.4930 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_007499	Both
C4B63_69g55 ⚠ monothiol glutaredoxin	—	OG7 Tb927.5.950 ↔ Tb927.8.4930 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_007499	OG7
C4B63_144g24 ⚠ monothiol glutaredoxin	—	OG7 Tb927.5.950 ↔ Tb927.8.4930 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_007499	OG7
C4B63_7g133 pyroglutamyl-peptidase I	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_010957 OG6 Tb927.4.2670 ↔ Tb927.8.4930 OG7 Tb927.4.2670 ↔ Tb927.8.4930 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_010957	Both
C4B63_99g106 ⚠ monothiol glutaredoxin	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_007499 OG6 Tb927.5.950 ↔ Tb927.8.4930 OG7 Tb927.5.950 ↔ Tb927.8.4930 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_007499	Both
C4B63_3g1086 ⚠ monothiol glutaredoxin	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_007499 OG6 Tb927.5.950 ↔ Tb927.8.4930 OG7 Tb927.5.950 ↔ Tb927.8.4930 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_007499	Both
C4B63_241g7 ⚠ Leucine-rich repeat-containing protein 34	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_007538 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_007538	Both
C4B63_29g6 ⚠ EEF1A lysine methyltransferase 4	—	OG6 Tb927.7.6890 ↔ Tb927.8.4930 OG7 Tb927.7.6890 ↔ Tb927.8.4930 OG7 Tb927.8.4930 ↔ Tb927.9.7000	Both
C4B63_33g10 ⚠ EEF1A lysine methyltransferase 4	—	OG6 Tb927.7.6890 ↔ Tb927.8.4930 OG7 Tb927.7.6890 ↔ Tb927.8.4930 OG7 Tb927.8.4930 ↔ Tb927.9.7000	Both
C4B63_16g163 Pyridoxal phosphate homeostasis protein	—	OG6 TCSYLVIO_000216 ↔ TCSYLVIO_001008 OG7 TCSYLVIO_000216 ↔ TCSYLVIO_001008	Both
C4B63_184g8 ⚠ GTP-binding protein	—	OG6 TCSYLVIO_000468 ↔ TCSYLVIO_001008 OG7 TCSYLVIO_000468 ↔ TCSYLVIO_001008	Both
C4B63_9g201 ⚠ GTP-binding protein	—	OG6 TCSYLVIO_000468 ↔ TCSYLVIO_001008 OG7 TCSYLVIO_000468 ↔ TCSYLVIO_001008	Both
C4B63_21g56 nucleoside phosphorylase	—	OG6 TCSYLVIO_000361 ↔ TCSYLVIO_001008 OG7 TCSYLVIO_000361 ↔ TCSYLVIO_001008	Both
C4B63_243g4 ⚠ Present in the outer mitochondrial membrane p	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_003157 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_003157	Both
C4B63_279g8 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_002972 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_002972	Both
C4B63_42g174 conserved hypothetical protein	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_003130 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_003130	Both
C4B63_17g188 ⚠ Phosphopantetheine adenylyltransferase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_004096 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_004096 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_006158	Both
C4B63_17g99 exportin 1	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_004194 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_004194	Both
C4B63_142g6 ⚠ GMP synthase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_001147 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_001147	Both
C4B63_238g18 ⚠ GMP synthase(fragment)	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_001147 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_001147	Both
C4B63_58g136 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_006832 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_006832	Both
C4B63_58g137 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_006832 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_006832	Both
C4B63_4g136 ⚠ N-myristoyl transferase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_006126 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_006126	Both
C4B63_35g191 6-phosphogluconolactonase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_007658 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_007658	Both
C4B63_4g357 Activator of 90 kDa heat shock protein ATPase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_006151 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_006151	Both
C4B63_69g27 35 kDa cyclophilin	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_003462	OG6
C4B63_6g148 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_002576 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_002576	Both
C4B63_92g63 ⚠ KH domain/Domain of unknown function (DUF1771	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_002786 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_002786	Both
C4B63_114g23 UBX domain-containing protein 3	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_001163 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_001163	Both
C4B63_129g42 ⚠ diphthine synthase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_002908 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_002908	Both
C4B63_44g252 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_002972 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_002972	Both
C4B63_31g106 conserved hypothetical protein	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_010565 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_010565	Both
C4B63_6g146 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_002576 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_002576	Both
C4B63_3g686 ⚠ Mucin-associated surface protein (MASP)	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_002495	OG6
C4B63_125g66 ⚠ Mucin-associated surface protein (MASP)	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_002495	OG6
C4B63_9g488 conserved hypothetical protein	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_004051	Both
C4B63_55g69 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_001023 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_001023	Both
C4B63_9g516 heat shock protein Hsp20	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_004068 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_004068	Both
C4B63_17g233 ⚠ iron superoxide dismutase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_010549 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_010549	Both
C4B63_31g228 ⚠ dihydroorotase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_008471 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_008471	Both
C4B63_21g282 mitogen-activated protein kinase 3	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_007367	OG6
C4B63_140g30 ⚠ diphthine synthase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_002908 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_002908	Both
C4B63_184g9 ⚠ protein phosphatase 2C	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_007482	OG6
C4B63_10g147 ⚠ carnitine O-acetyltransferase(fragment)	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_004300	OG6
C4B63_259g9 ⚠ Ran-binding protein	—	OG6 TCSYLVIO_000197 ↔ TCSYLVIO_001008 OG7 TCSYLVIO_000197 ↔ TCSYLVIO_001008	Both
C4B63_246g7 ⚠ Gastrulation defective protein 1 homolog	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_004877 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_004877	Both
C4B63_11g25 conserved hypothetical protein	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_006390 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_006390	Both
C4B63_20g213 ⚠ enoyl-CoA hydratase/isomerase family protein	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_005344 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_005344	Both
C4B63_188g43 conserved hypothetical protein	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_009863 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_009863	Both
C4B63_4g383 ⚠ mevalonate-diphosphate decarboxylase	—	OG6 TCSYLVIO_001008 ↔ TCSYLVIO_006134 OG7 TCSYLVIO_001008 ↔ TCSYLVIO_006134	Both

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