C4B63_21g247

conserved hypothetical protein
Trypanosoma cruzi Dm28c 2018 OG6: OG6_105708 OG7: OG7_0043625 149 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 149 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_41g119 ⚠
conserved hypothetical protein
— OG7
C4B63_153g40 ⚠
inositol 5-phosphatase 1
— Both
C4B63_153g41 ⚠
inositol 5-phosphatase 1(fragment)
— Both
C4B63_76g41
Probable S-adenosyl-L-methionine-binding prot
— Both
C4B63_44g120
conserved hypothetical protein
— Both
C4B63_83g73
ribonucleoprotein p18, mitochondrial precurso
— Both
C4B63_85g64
DNA-damage inducible protein DDI1-like protei
— Both
C4B63_32g256 ⚠
PFU (PLAA family ubiquitin binding)
— Both
C4B63_32g255 ⚠
WD domain, G-beta repeat
— Both
C4B63_42g99
E3 ubiquitin-protein ligase HEL2
— Both
C4B63_4g116
FACT complex subunit ssrp1-B
— Both
C4B63_160g6 ⚠
poly(A)-specific ribonuclease PARN
— Both
C4B63_16g30 ⚠
poly(A)-specific ribonuclease PARN
— Both
C4B63_63g95 ⚠
poly(A)-specific ribonuclease PARN
— Both
C4B63_76g32
guide RNA associated protein, GAP2
— Both
C4B63_22g11 ⚠
developmentally regulated phosphoprotein
— Both
C4B63_24g190 ⚠
Exportin-7
— Both
C4B63_21g30 ⚠
Exportin-7-A
— Both
C4B63_102g61 ⚠
aspartyl-tRNA synthetase
— Both
C4B63_42g202 ⚠
aspartyl-tRNA synthetase
— Both
C4B63_42g203 ⚠
aspartyl-tRNA synthetase
— Both
C4B63_168g16 ⚠
aspartyl-tRNA synthetase
— Both
C4B63_11g484
Leucine Rich Repeat protein
— Both
C4B63_23g248 ⚠
inorganic pyrophosphatase
— Both
C4B63_70g77 ⚠
acidocalcisomal pyrophosphatase
— Both
C4B63_54g57
vacuolar ATP synthase subunit d
— Both
C4B63_14g155
Leucine-rich repeat-containing protein 74A
— Both
C4B63_122g21 ⚠
ubiquitin ligase
— Both
C4B63_149g26
GDP-mannose pyrophosphorylase
— Both
C4B63_27g4 ⚠
ubiquitin ligase
— Both
C4B63_95g23
N(2), N(2)-dimethylguanosine tRNA methyltrans
— Both
C4B63_42g187
conserved hypothetical protein
— Both
C4B63_32g239 ⚠
tubulin folding cofactor D
— Both
C4B63_32g238 ⚠
tubulin folding cofactor D
— Both
C4B63_19g264 ⚠
conserved hypothetical protein
— OG7
C4B63_56g88 ⚠
Zinc finger C2HC domain-containing protein 1C
— OG7
C4B63_13g113 ⚠
zinc-finger of a C2HC-type
— OG7
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_2g83 ⚠
ubiquitin hydrolase
— OG7
C4B63_2g75 ⚠
poly(A)-specific ribonuclease PARN(fragment)
— OG7
C4B63_61g59 ⚠
Protein kinase domain
— OG7
C4B63_2g365 ⚠
dual-specificity protein kinase
— OG7
C4B63_25g120 ⚠
Protein kinase domain
— OG7
C4B63_52g51 ⚠
serine/threonine protein kinase
— OG7
C4B63_52g128 ⚠
protein kinase
— OG7
C4B63_85g75 ⚠
ubiquitin activating enzyme
— OG7
C4B63_14g158 ⚠
serine/threonine kinase
— OG7
C4B63_52g127 ⚠
protein kinase
— OG7
C4B63_40g106 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
C4B63_7g377 ⚠
[Pyruvate dehydrogenase (acetyl-transferring)
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.