C4B63_95g23

N(2), N(2)-dimethylguanosine tRNA methyltransferase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101071 OG7: OG7_0004550 78 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 78 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_3g551 ⚠
NADH-dependent fumarate reductase
— Both
C4B63_13g166 ⚠
leucine carboxyl methyltransferase
— OG7
C4B63_32g238 ⚠
tubulin folding cofactor D
— Both
C4B63_227g4 ⚠
Zinc finger protein 474
— Both
C4B63_47g49 ⚠
tRNA pseudouridine synthase 1
— Both
C4B63_43g143 ⚠
protein kinase
— Both
C4B63_4g269
conserved hypothetical protein
— Both
C4B63_22g161 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_42g99
E3 ubiquitin-protein ligase HEL2
— Both
C4B63_85g64
DNA-damage inducible protein DDI1-like protei
— Both
C4B63_61g59 ⚠
Protein kinase domain
— OG7
C4B63_3g554 ⚠
NADH-dependent fumarate reductase
— Both
C4B63_44g120
conserved hypothetical protein
— Both
C4B63_42g221
kinesin
— OG6
C4B63_4g378 ⚠
Zinc finger C2HC domain-containing protein 1C
— Both
C4B63_39g357
ATP synthase
— Both
C4B63_3g552 ⚠
NADH-dependent fumarate reductase
— Both
C4B63_4g377 ⚠
Zinc finger protein 474
— Both
C4B63_7g347
V-type ATPase, A subunit
— Both
C4B63_32g239 ⚠
tubulin folding cofactor D
— Both
C4B63_8g540 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG7
C4B63_133g51
heat shock protein 70
— OG7
C4B63_52g127 ⚠
protein kinase
— OG7
C4B63_14g158 ⚠
serine/threonine kinase
— OG7
C4B63_7g79 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_13g160 ⚠
6-phosphofructo-2-kinase/fructose-2,6-bisphos
— OG7
C4B63_18g32 ⚠
pseudouridine synthase A-like protein
— OG7
C4B63_4g514 ⚠
tRNA pseudouridine synthase A-like protein
— OG7
C4B63_19g264 ⚠
conserved hypothetical protein
— OG7
C4B63_52g128 ⚠
protein kinase
— OG7
C4B63_15g18 ⚠
NADH-dependent fumarate reductase
— Both
C4B63_43g202 ⚠
hook complex protein, conserved
— OG7
C4B63_52g51 ⚠
serine/threonine protein kinase
— OG7
C4B63_25g120 ⚠
Protein kinase domain
— OG7
C4B63_8g527 ⚠
pseudouridylate synthase I
— OG7
C4B63_13g113 ⚠
zinc-finger of a C2HC-type
— OG7
C4B63_56g88 ⚠
Zinc finger C2HC domain-containing protein 1C
— OG7
C4B63_2g365 ⚠
dual-specificity protein kinase
— OG7
C4B63_271g10 ⚠
conserved hypothetical protein
— OG7
C4B63_10g522
FACT complex subunit SPT16
— Both
C4B63_15g19 ⚠
NADH-dependent fumarate reductase
— Both
C4B63_45g121 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— Both
C4B63_43g175
2-oxoisovalerate dehydrogenase alpha subunit
— Both
C4B63_21g247
conserved hypothetical protein
— Both
C4B63_54g71 ⚠
NADH-dependent fumarate reductase
— Both
C4B63_4g258
prolyl-tRNA synthetase
— Both
C4B63_3g550 ⚠
NADH-dependent fumarate reductase
— Both
C4B63_42g202 ⚠
aspartyl-tRNA synthetase
— Both
C4B63_54g80
conserved hypothetical protein
— Both
C4B63_38g169 ⚠
calpain-like cysteine peptidase
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.