C4B63_27g4

ubiquitin ligase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_147102 OG7: OG7_0002890 107 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
Applies on "Apply filters".
Reset
⬇ CSV
Network view all shared interactors, plus up to 150 more
Show:

Selection: Shift+drag also box-selects. Drag any selected node to move the whole selection.
Interactions 107 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_13g160 ⚠
6-phosphofructo-2-kinase/fructose-2,6-bisphos
— OG7
C4B63_128g59 ⚠
dihydrolipoamide branched chain transacylase
— Both
C4B63_21g247 ⚠
conserved hypothetical protein
— Both
C4B63_7g134 ⚠
conserved hypothetical protein
— Both
C4B63_149g26 ⚠
GDP-mannose pyrophosphorylase
— Both
C4B63_38g169 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_22g11 ⚠
developmentally regulated phosphoprotein
— Both
C4B63_31g99 ⚠
WD repeat-containing protein 17
— Both
C4B63_21g259 ⚠
Small RNA degrading nuclease 5
— Both
C4B63_43g126 ⚠
ATP synthase F1 subunit gamma protein
— Both
C4B63_153g40 ⚠
inositol 5-phosphatase 1
— Both
C4B63_22g164 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_31g76 ⚠
ubiquitin-activating enzyme
— Both
C4B63_39g359 ⚠
conserved hypothetical protein
— Both
C4B63_72g79 ⚠
inositol 5-phosphatase 1
— Both
C4B63_101g15 ⚠
serine peptidase, Clan SC, Family S9B
— Both
C4B63_22g161 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_3g1104 ⚠
threonyl-tRNA synthetase
— Both
C4B63_153g41 ⚠
inositol 5-phosphatase 1(fragment)
— Both
C4B63_42g187 ⚠
conserved hypothetical protein
— Both
C4B63_32g239 ⚠
tubulin folding cofactor D
— Both
C4B63_32g238 ⚠
tubulin folding cofactor D
— Both
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_43g202 ⚠
hook complex protein, conserved
— OG7
C4B63_271g10 ⚠
conserved hypothetical protein
— OG7
C4B63_45g121 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG7
C4B63_23g264 ⚠
6-phosphofructo-2-kinase 1
— OG7
C4B63_85g75 ⚠
ubiquitin activating enzyme
— OG7
C4B63_12g219 ⚠
adaptin-related protein-like
— OG7
C4B63_40g106 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
C4B63_14g103 ⚠
beta adaptin
— OG7
C4B63_13g166 ⚠
leucine carboxyl methyltransferase
— OG7
C4B63_102g61 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_168g16 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_42g203 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_252g9 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG7
C4B63_2g502 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG7
C4B63_42g202 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_2g83 ⚠
ubiquitin hydrolase
— OG7
C4B63_396g8 ⚠
synaptojanin (N-terminal domain)
— OG7
C4B63_28g111 ⚠
synaptojanin
— OG7
C4B63_41g125 ⚠
conserved hypothetical protein
— OG7
C4B63_2g74 ⚠
poly(A)-specific ribonuclease PARN(fragment)
— OG7
C4B63_2g75 ⚠
poly(A)-specific ribonuclease PARN(fragment)
— OG7
C4B63_7g377 ⚠
[Pyruvate dehydrogenase (acetyl-transferring)
— OG7
C4B63_13g257 ⚠
endonuclease/exonuclease/phosphatase
— OG7
C4B63_26g245 ⚠
inositol/phosphatidylinositol phosphatase
— OG7
C4B63_41g119 ⚠
conserved hypothetical protein
— OG7
C4B63_2g203 ⚠
synaptojanin (N-terminal domain)
— OG7
C4B63_20g38 ⚠
Synaptojanin
— OG7
Page 1 of 3
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.