C4B63_4g181

Sestrin-3
Trypanosoma cruzi Dm28c 2018 OG6: OG6_141922 OG7: OG7_0006056 95 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 95 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_49g325c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_171g30 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
C4B63_6g592 ⚠
pumilio/PUF RNA binding protein 5
— OG7
C4B63_157g28 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
C4B63_22g175 ⚠
pumilio/PUF RNA binding protein 9
— OG7
C4B63_413g14 ⚠
pumilio/PUF RNA binding protein 4
— OG7
C4B63_46g15 ⚠
Kinesin-13 5
— OG7
C4B63_75g61 ⚠
calmodulin
— OG7
C4B63_13g170 ⚠
pumilio/PUF RNA binding protein 1
— OG7
C4B63_439g12 ⚠
pumilio/PUF RNA binding protein 4
— OG7
C4B63_8g527 ⚠
pseudouridylate synthase I
— OG7
C4B63_9g489
conserved hypothetical protein
— OG7
C4B63_144g30 ⚠
Kinesin-13 1
— OG7
C4B63_48g123 ⚠
neurobeachin/beige protein
— OG7
C4B63_48g124 ⚠
neurobeachin/beige protein
— OG7
C4B63_14g171 ⚠
ubiquitin-protein ligase
— OG7
C4B63_271g10 ⚠
conserved hypothetical protein
— OG7
C4B63_325g1 ⚠
Kinesin-13 1
— OG7
C4B63_41g148 ⚠
pumilio/PUF RNA binding protein 4
— OG7
C4B63_63g81 ⚠
protein transport protein Sec23A
— OG7
C4B63_56g51 ⚠
RNA-binding protein
— OG7
C4B63_56g50 ⚠
Surp module,
— OG7
C4B63_17g179 ⚠
Importin subunit beta-3
— OG7
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_197g36 ⚠
conserved hypothetical protein
— OG7
C4B63_25g202 ⚠
conserved hypothetical protein
— OG7
C4B63_72g98 ⚠
RNA pseudouridylate synthase protein
— OG7
C4B63_8g52 ⚠
tRNA pseudouridine(31) synthase
— OG7
C4B63_17g182
phosphatidylinositol 3-kinase catalytic subun
— OG7
C4B63_112g13 ⚠
neurobeachin/beige-like protein(fragment)
— OG7
C4B63_43g137 ⚠
pumilio/PUF RNA binding protein 3
— OG7
C4B63_47g49 ⚠
tRNA pseudouridine synthase 1
— OG7
C4B63_48g122 ⚠
neurobeachin/beige protein
— OG7
C4B63_13g1005c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_293g30c ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_4g509 ⚠
FKBP-type peptidylprolyl cis-trans isomerase
— OG7
C4B63_10g524 ⚠
nuclear transcription factor
— Both
C4B63_8g190 ⚠
conserved hypothetical protein
— OG7
C4B63_2g88 ⚠
ubiquitin-protein ligase
— OG7
C4B63_7g382 ⚠
ubiquitin-protein ligase
— OG7
C4B63_112g14 ⚠
neurobeachin/beige-like protein
— OG7
C4B63_69g61 ⚠
Kinesin-13 1
— OG7
C4B63_4g63
polyprenyl synthase
— OG7
C4B63_4g514 ⚠
tRNA pseudouridine synthase A-like protein
— OG7
C4B63_4g508 ⚠
peptidyl-prolyl cis-trans isomerase
— OG7
C4B63_142g11 ⚠
Protein shuttle craft
— OG7
C4B63_44g235 ⚠
Kinesin-13 4
— OG7
C4B63_43g202 ⚠
hook complex protein, conserved
— OG7
C4B63_18g147 ⚠
calmodulin
— Both
C4B63_22g94
cyclophilin 15
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.