C4B63_23g143

dihydrolipoamide dehydrogenase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_127035 OG7: OG7_0001633 136 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 136 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_326g16 ⚠
dihydrolipoamide dehydrogenase
— +1 more Both
C4B63_124g1 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_17g277 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_17g278 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_22g113 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_63g101 ⚠
Phosphatidylinositol 3-kinase tor1
— OG7
C4B63_7g380 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_7g424 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_124g3 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_34g361 ⚠
phosphatidylinositol kinase related protein
— OG7
C4B63_124g2 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_10g280 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_19g82 ⚠
RNA polymerase I second largest subunit
— OG7
C4B63_279g5 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_194g21 ⚠
DNA-directed RNA polymerase III
— OG7
C4B63_279g6 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_44g250 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_358g1 ⚠
dihydrolipoamide dehydrogenase
— +1 more Both
C4B63_249g23 ⚠
dihydrolipoamide dehydrogenase
— +1 more Both
C4B63_249g22 ⚠
dihydrolipoamide dehydrogenase
— +1 more Both
C4B63_326g15 ⚠
dihydrolipoamide dehydrogenase
— +1 more Both
C4B63_42g232 ⚠
ubiquitin hydrolase
— OG7
C4B63_9g329 ⚠
Beige/BEACH domain
— OG7
C4B63_358g16 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_255g16 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_48g124 ⚠
neurobeachin/beige protein
— OG7
C4B63_48g123 ⚠
neurobeachin/beige protein
— OG7
C4B63_55g67 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
C4B63_9g327 ⚠
conserved hypothetical protein
— OG7
C4B63_321g29 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_48g122 ⚠
neurobeachin/beige protein
— OG7
C4B63_47g56 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_112g13 ⚠
neurobeachin/beige-like protein(fragment)
— OG7
C4B63_30g206 ⚠
conserved hypothetical protein
— OG7
C4B63_31g220 ⚠
conserved hypothetical protein
— OG7
C4B63_70g99 ⚠
conserved hypothetical protein
— OG7
C4B63_70g86 ⚠
conserved hypothetical protein
— OG7
C4B63_12g8 ⚠
conserved hypothetical protein
— OG7
C4B63_49g186 ⚠
ccr4-not transcription complex subunit
— OG7
C4B63_12g314 ⚠
conserved hypothetical protein
— OG7
C4B63_267g12 ⚠
conserved hypothetical protein
— OG7
C4B63_32g232 ⚠
conserved hypothetical protein
— OG7
C4B63_31g226 ⚠
glutamine dependent carbamoyl-phosphate synth
— OG7
C4B63_60g76 ⚠
glutamine-dependent carbamoyl-phosphate synth
— OG7
C4B63_60g78 ⚠
glutamine dependent carbamoyl-phosphate synth
— OG7
C4B63_44g236 ⚠
conserved hypothetical protein
— OG7
C4B63_60g75 ⚠
glutamine-dependent carbamoyl-phosphate synth
— OG7
C4B63_60g77 ⚠
glutamine dependent carbamoyl-phosphate synth
— OG7
C4B63_4g202 ⚠
Periodic tryptophan protein 2 homolog
— OG7
C4B63_7g395 ⚠
conserved hypothetical protein
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.