C4B63_40g114

glycosyl hydrolase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_103857 OG7: OG7_0008824 177 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 177 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_44g149
conserved hypothetical protein
— Both
C4B63_63g101 ⚠
Phosphatidylinositol 3-kinase tor1
— OG7
C4B63_22g113 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_124g2 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_34g361 ⚠
phosphatidylinositol kinase related protein
— OG7
C4B63_124g3 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_7g424 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_17g278 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_17g277 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_124g1 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_7g87
Alpha,alpha-trehalose phosphorylase
— Both
C4B63_7g380 ⚠
phosphatidylinositol 3-kinase(fragment)
— Both
C4B63_4g201 ⚠
Protein ILITYHIA
— +2 more Both
C4B63_4g200 ⚠
conserved hypothetical protein
— +2 more Both
C4B63_9g328 ⚠
conserved hypothetical protein
— OG7
C4B63_19g265 ⚠
F-box protein dre-1
— Both
C4B63_19g267 ⚠
Right handed beta helix region containing pro
— Both
C4B63_52g72
WD repeat-containing protein 3
— Both
C4B63_112g35 ⚠
Unconventional myosin
— OG6
C4B63_80g4 ⚠
Unconventional myosin
— OG6
C4B63_31g47 ⚠
myosin heavy chain MYA2-related
— OG6
C4B63_14g199 ⚠
myosin heavy chain
— OG6
C4B63_94g50 ⚠
myosin heavy chain
— OG6
C4B63_47g94 ⚠
Myosin motor domain superfamily protein
— OG6
C4B63_30g117 ⚠
Unconventional myosin
— OG6
C4B63_21g237 ⚠
myosin heavy chain
— OG6
C4B63_149g23
conserved hypothetical protein
— Both
C4B63_31g109 ⚠
ribose-phosphate pyrophosphokinase
— Both
C4B63_4g264 ⚠
Protein kintoun
— Both
C4B63_6g490
Vacuole membrane protein 1
— Both
C4B63_30g206
conserved hypothetical protein
— Both
C4B63_44g250 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_279g6 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_194g21 ⚠
DNA-directed RNA polymerase III
— OG7
C4B63_279g5 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_14g147 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_59g118 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_2g380 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_2g215 ⚠
PIH1 domain-containing protein 1
— OG7
C4B63_4g265 ⚠
pre-RNA processing PIH1/Nop17
— OG7
C4B63_26g318 ⚠
conserved hypothetical protein
— OG7
C4B63_136g39 ⚠
conserved hypothetical protein
— OG7
C4B63_14g103 ⚠
beta adaptin
— OG7
C4B63_63g32 ⚠
adaptin-related protein-like
— OG7
C4B63_12g219 ⚠
adaptin-related protein-like
— OG7
C4B63_23g143 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_10g280 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_113g34 ⚠
ABC transporter
— OG7
C4B63_38g158 ⚠
Poly(A) RNA polymerase cid14
— OG7
C4B63_137g45 ⚠
receptor for activated C kinase 1
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.