C4B63_4g200

conserved hypothetical protein

Trypanosoma cruzi Dm28c 2018 OG6: OG6_102176 OG7: OG7_0007065 201 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 201 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_47g107 ⚠ ABC transporter	—	OG6 TCSYLVIO_004518 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_004518 ↔ TCSYLVIO_006208 OG6 LdBPK_030150.1 ↔ LdBPK_180820.1 OG7 TCSYLVIO_004518 ↔ TCSYLVIO_006209 +2 more	Both
C4B63_252g9 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG7 TCSYLVIO_005373 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_005373 ↔ TCSYLVIO_006208 OG7 LdBPK_120170.1 ↔ LdBPK_180820.1	OG7
C4B63_2g502 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG7 TCSYLVIO_005373 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_005373 ↔ TCSYLVIO_006208 OG7 LdBPK_120170.1 ↔ LdBPK_180820.1	OG7
C4B63_2g83 ⚠ ubiquitin hydrolase	—	OG7 TCSYLVIO_005373 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_005373 ↔ TCSYLVIO_006208 OG7 LdBPK_120170.1 ↔ LdBPK_180820.1	OG7
C4B63_80g25 ⚠ ubiquitin hydrolase	—	OG6 TCSYLVIO_005373 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_005373 ↔ TCSYLVIO_006208 OG7 TCSYLVIO_005373 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_005373 ↔ TCSYLVIO_006208 +1 more	Both
C4B63_4g502 ⚠ ABC transporter	—	OG7 TCSYLVIO_004518 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_004518 ↔ TCSYLVIO_006208 OG7 LdBPK_030150.1 ↔ LdBPK_180820.1	OG7
C4B63_113g34 ⚠ ABC transporter	—	OG7 TCSYLVIO_004518 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_004518 ↔ TCSYLVIO_006208 OG7 LdBPK_030150.1 ↔ LdBPK_180820.1	OG7
C4B63_40g114 ⚠ glycosyl hydrolase	—	OG6 TCSYLVIO_006208 ↔ TCSYLVIO_008282 OG6 TCSYLVIO_006209 ↔ TCSYLVIO_008282 OG6 LdBPK_180820.1 ↔ LdBPK_365470.1 OG7 TCSYLVIO_006208 ↔ TCSYLVIO_008282 +2 more	Both
C4B63_7g87 ⚠ Alpha,alpha-trehalose phosphorylase	—	OG6 TCSYLVIO_003875 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_003875 ↔ TCSYLVIO_006208 OG6 LdBPK_180820.1 ↔ LdBPK_342000.1 OG7 TCSYLVIO_003875 ↔ TCSYLVIO_006209 +2 more	Both
C4B63_16g21 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_000050 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_000050 ↔ TCSYLVIO_006208 OG6 LdBPK_180820.1 ↔ LdBPK_230610.1 OG7 TCSYLVIO_000050 ↔ TCSYLVIO_006209 +2 more	Both
C4B63_16g20 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_000050 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_000050 ↔ TCSYLVIO_006208 OG6 LdBPK_180820.1 ↔ LdBPK_230610.1 OG7 TCSYLVIO_000050 ↔ TCSYLVIO_006209 +2 more	Both
C4B63_16g22 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_000050 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_000050 ↔ TCSYLVIO_006208 OG6 LdBPK_180820.1 ↔ LdBPK_230610.1 OG7 TCSYLVIO_000050 ↔ TCSYLVIO_006209 +2 more	Both
C4B63_206g11 ⚠ ABC transporter	—	OG6 TCSYLVIO_004518 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_004518 ↔ TCSYLVIO_006208 OG6 LdBPK_030150.1 ↔ LdBPK_180820.1 OG7 TCSYLVIO_004518 ↔ TCSYLVIO_006209 +2 more	Both
C4B63_44g149 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_002937 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_002937 ↔ TCSYLVIO_006208 OG6 LdBPK_180820.1 ↔ LdBPK_311230.1 OG7 TCSYLVIO_002937 ↔ TCSYLVIO_006209 +2 more	Both
C4B63_83g68 ⚠ protein phosphatase 2C	—	OG6 TCSYLVIO_002422 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_002422 ↔ TCSYLVIO_006208	OG6
C4B63_30g226 ⚠ lipin	—	OG6 TCSYLVIO_001856 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_001856 ↔ TCSYLVIO_006208 OG7 TCSYLVIO_001856 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_001856 ↔ TCSYLVIO_006208	Both
C4B63_2g729 ⚠ structural maintenance of chromosome (SMC) fa	—	OG7 LdBPK_080010.1 ↔ LdBPK_180820.1	OG7
C4B63_233g31 ⚠ ubiquitin hydrolase	—	OG7 TCSYLVIO_006208 ↔ TCSYLVIO_007047 OG7 TCSYLVIO_006209 ↔ TCSYLVIO_007047	OG7
C4B63_233g32 ⚠ ubiquitin hydrolase	—	OG7 TCSYLVIO_006208 ↔ TCSYLVIO_007047 OG7 TCSYLVIO_006209 ↔ TCSYLVIO_007047	OG7
C4B63_7g392 ⚠ ubiquitin hydrolase	—	OG7 TCSYLVIO_006208 ↔ TCSYLVIO_007047 OG7 TCSYLVIO_006209 ↔ TCSYLVIO_007047	OG7
C4B63_7g391 ⚠ ubiquitin hydrolase	—	OG7 TCSYLVIO_006208 ↔ TCSYLVIO_007047 OG7 TCSYLVIO_006209 ↔ TCSYLVIO_007047	OG7
C4B63_2g4 ⚠ ubiquitin hydrolase	—	OG7 TCSYLVIO_006208 ↔ TCSYLVIO_007047 OG7 TCSYLVIO_006209 ↔ TCSYLVIO_007047	OG7
C4B63_21g86 ⚠ conserved hypothetical protein	—	OG7 LdBPK_100850.1 ↔ LdBPK_180820.1	OG7
C4B63_259g8 ⚠ DNA polymerase theta (helicase domain only)	—	OG7 LdBPK_130390.1 ↔ LdBPK_180820.1	OG7
C4B63_17g284 ⚠ ATP-dependent DNA DEAD/DEAH box helicase	—	OG7 LdBPK_130390.1 ↔ LdBPK_180820.1	OG7
C4B63_186g23 ⚠ ATP-dependent DEAD/H RNA helicase(fragment)	—	OG7 LdBPK_130390.1 ↔ LdBPK_180820.1	OG7
C4B63_16g132 ⚠ DNA polymerase theta (helicase domain only)	—	OG7 LdBPK_130390.1 ↔ LdBPK_180820.1	OG7
C4B63_47g56 ⚠ RNA polymerase IIA largest subunit	—	OG7 LdBPK_161420.1 ↔ LdBPK_180820.1	OG7
C4B63_321g29 ⚠ RNA polymerase IIA largest subunit	—	OG7 LdBPK_161420.1 ↔ LdBPK_180820.1	OG7
C4B63_255g16 ⚠ RNA polymerase IIA largest subunit	—	OG7 LdBPK_161420.1 ↔ LdBPK_180820.1	OG7
C4B63_358g16 ⚠ RNA polymerase IIA largest subunit	—	OG7 LdBPK_161420.1 ↔ LdBPK_180820.1	OG7
C4B63_104g75 ⚠ RNA polymerase IIA largest subunit	—	OG7 LdBPK_161420.1 ↔ LdBPK_180820.1	OG7
C4B63_104g76 ⚠ RNA polymerase IIA largest subunit	—	OG7 LdBPK_161420.1 ↔ LdBPK_180820.1	OG7
C4B63_9g487 ⚠ histone deacetylase	—	OG7 LdBPK_081300.1 ↔ LdBPK_180820.1	OG7
C4B63_46g54 ⚠ Dpy-30 motif containing protein	—	OG7 TCSYLVIO_000435 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_000435 ↔ TCSYLVIO_006208	OG7
C4B63_37g373 ⚠ ribosome biogenesis protein	—	OG6 TCSYLVIO_000956 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_000956 ↔ TCSYLVIO_006208 OG7 TCSYLVIO_000956 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_000956 ↔ TCSYLVIO_006208	Both
C4B63_14g199 ⚠ myosin heavy chain	—	OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006208	OG6
C4B63_94g50 ⚠ myosin heavy chain	—	OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006208	OG6
C4B63_47g94 ⚠ Myosin motor domain superfamily protein	—	OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006208	OG6
C4B63_30g117 ⚠ Unconventional myosin	—	OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006208	OG6
C4B63_21g237 ⚠ myosin heavy chain	—	OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006208	OG6
C4B63_31g109 ⚠ ribose-phosphate pyrophosphokinase	—	OG6 LdBPK_080520.1 ↔ LdBPK_180820.1 OG7 LdBPK_080520.1 ↔ LdBPK_180820.1	Both
C4B63_80g4 ⚠ Unconventional myosin	—	OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006208	OG6
C4B63_112g35 ⚠ Unconventional myosin	—	OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_005358 ↔ TCSYLVIO_006208	OG6
C4B63_46g13 ⚠ mitochondrial DNA polymerase I protein D	—	OG6 TCSYLVIO_003485 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_003485 ↔ TCSYLVIO_006208 OG7 TCSYLVIO_003485 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_003485 ↔ TCSYLVIO_006208	Both
C4B63_62g90 ⚠ ribosome biogenesis protein	—	OG6 TCSYLVIO_000956 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_000956 ↔ TCSYLVIO_006208 OG7 TCSYLVIO_000956 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_000956 ↔ TCSYLVIO_006208	Both
C4B63_6g119 ⚠ oxidoreductase-like protein	—	OG6 TCSYLVIO_002566 ↔ TCSYLVIO_006209 OG6 TCSYLVIO_002566 ↔ TCSYLVIO_006208 OG7 TCSYLVIO_002566 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_002566 ↔ TCSYLVIO_006208	Both
C4B63_26g318 ⚠ conserved hypothetical protein	—	OG7 LdBPK_150740.1 ↔ LdBPK_180820.1	OG7
C4B63_2g380 ⚠ phosphoribosylpyrophosphate synthetase	—	OG7 LdBPK_080520.1 ↔ LdBPK_180820.1	OG7
C4B63_51g200 ⚠ mitochondrial DNA polymerase I protein B	—	OG7 TCSYLVIO_003485 ↔ TCSYLVIO_006209 OG7 TCSYLVIO_003485 ↔ TCSYLVIO_006208	OG7

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