C4B63_21g277

conserved hypothetical protein
Trypanosoma cruzi Dm28c 2018 OG6: OG6_163296 OG7: OG7_0051916 114 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 114 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_52g136 ⚠
Cytoplasmic dynein 1 intermediate chain
— OG7
C4B63_6g279 ⚠
Coatomer subunit gamma
— Both
C4B63_63g7 ⚠
eukaryotic translation initiation factor 3 su
— Both
C4B63_8g210 ⚠
FYVE zinc-finger
— OG6
C4B63_7g421
coatomer alpha subunit
— Both
C4B63_7g395
conserved hypothetical protein
— Both
C4B63_7g67 ⚠
Sec7 guanine-nucleotide exchange factor
— Both
C4B63_192g23 ⚠
conserved hypothetical protein
— Both
C4B63_7g68 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— Both
C4B63_286g18 ⚠
eukaryotic translation initiation factor 3 su
— Both
C4B63_87g27 ⚠
Eukaryotic membrane protein family
— Both
C4B63_87g28 ⚠
Protein TAPT1 homolog
— Both
C4B63_31g109 ⚠
ribose-phosphate pyrophosphokinase
— Both
C4B63_43g210 ⚠
conserved hypothetical protein
— OG7
C4B63_43g211 ⚠
conserved hypothetical protein
— OG7
C4B63_14g147 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_59g118 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_2g380 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_9g487 ⚠
histone deacetylase
— OG7
C4B63_16g132 ⚠
DNA polymerase theta (helicase domain only)
— OG7
C4B63_186g23 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG7
C4B63_17g284 ⚠
ATP-dependent DNA DEAD/DEAH box helicase
— OG7
C4B63_259g8 ⚠
DNA polymerase theta (helicase domain only)
— OG7
C4B63_10g507 ⚠
DNA-directed RNA polymerases I and III subuni
— OG7
C4B63_93g92 ⚠
Myotubularin-related protein
— OG7
C4B63_41g138 ⚠
myotubularin
— OG7
C4B63_192g4 ⚠
adenylate kinase 1
— OG7
C4B63_48g169 ⚠
adenylate kinase 1
— OG7
C4B63_38g67 ⚠
adenylate kinase
— OG7
C4B63_2g60 ⚠
conserved hypothetical protein
— OG7
C4B63_2g729 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
C4B63_43g187 ⚠
structural maintenance of chromosome protein
— OG7
C4B63_14g249 ⚠
structural maintenance of chromosome 3
— OG7
C4B63_4g502 ⚠
ABC transporter
— OG7
C4B63_113g34 ⚠
ABC transporter
— OG7
C4B63_252g9 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG7
C4B63_2g502 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG7
C4B63_2g83 ⚠
ubiquitin hydrolase
— OG7
C4B63_80g25 ⚠
ubiquitin hydrolase
— OG7
C4B63_4g526
conserved hypothetical protein
— OG7
C4B63_4g265 ⚠
pre-RNA processing PIH1/Nop17
— OG7
C4B63_2g215 ⚠
PIH1 domain-containing protein 1
— OG7
C4B63_10g514 ⚠
WD domain, G-beta repeat
— OG7
C4B63_7g55 ⚠
conserved hypothetical protein
— OG7
C4B63_7g57 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_87g21 ⚠
conserved hypothetical protein
— OG7
C4B63_2g63 ⚠
conserved hypothetical protein
— OG7
C4B63_28g54 ⚠
Dynein intermediate chain 1, axonemal
— OG7
C4B63_2g62 ⚠
conserved hypothetical protein
— OG7
C4B63_81g14 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.