C4B63_127g51

acetyl-CoA carboxylase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101052 OG7: OG7_0001434 229 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 229 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_59g118 ⚠
phosphoribosylpyrophosphate synthetase
— +5 more Both
C4B63_14g147 ⚠
phosphoribosylpyrophosphate synthetase
— +6 more Both
C4B63_2g380 ⚠
phosphoribosylpyrophosphate synthetase
— +6 more Both
C4B63_31g109 ⚠
ribose-phosphate pyrophosphokinase
— +5 more Both
C4B63_47g56 ⚠
RNA polymerase IIA largest subunit
— Both
C4B63_321g29 ⚠
RNA polymerase IIA largest subunit
— Both
C4B63_255g16 ⚠
RNA polymerase IIA largest subunit
— Both
C4B63_358g16 ⚠
RNA polymerase IIA largest subunit
— Both
C4B63_104g75 ⚠
RNA polymerase IIA largest subunit
— Both
C4B63_104g76 ⚠
RNA polymerase IIA largest subunit
— Both
C4B63_16g132 ⚠
DNA polymerase theta (helicase domain only)
— OG7
C4B63_186g23 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG7
C4B63_17g284 ⚠
ATP-dependent DNA DEAD/DEAH box helicase
— OG7
C4B63_259g8 ⚠
DNA polymerase theta (helicase domain only)
— OG7
C4B63_25g185 ⚠
ATP-dependent RNA helicase
— Both
C4B63_51g90 ⚠
ATP-dependent RNA helicase
— Both
C4B63_55g67 ⚠
DNA-directed rna polymerase I largest subunit
— Both
C4B63_16g21 ⚠
conserved hypothetical protein
— Both
C4B63_136g39 ⚠
conserved hypothetical protein
— OG7
C4B63_26g318 ⚠
conserved hypothetical protein
— OG7
C4B63_279g5 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_194g21 ⚠
DNA-directed RNA polymerase III
— OG7
C4B63_279g6 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_44g250 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_70g80 ⚠
proteasome alpha 7 subunit
— Both
C4B63_42g107
conserved hypothetical protein
— Both
C4B63_44g149
conserved hypothetical protein
— Both
C4B63_52g72
WD repeat-containing protein 3
— Both
C4B63_19g267 ⚠
Right handed beta helix region containing pro
— Both
C4B63_19g265 ⚠
F-box protein dre-1
— Both
C4B63_19g266 ⚠
conserved hypothetical protein
— Both
C4B63_21g277
conserved hypothetical protein
— Both
C4B63_112g19
proteasome beta 3 subunit
— Both
C4B63_34g309
proteasome regulatory non-ATPase subunit 6
— Both
C4B63_4g200 ⚠
conserved hypothetical protein
— Both
C4B63_4g201 ⚠
Protein ILITYHIA
— Both
C4B63_267g17 ⚠
cullin 4B
— OG6
C4B63_47g55
eukaryotic translation initiation factor 5
— Both
C4B63_47g105 ⚠
acetyltransferase
— Both
C4B63_17g180
RNA-binding protein,
— Both
C4B63_23g275 ⚠
ATP-dependent DEAD/H RNA helicase
— Both
C4B63_26g247 ⚠
conserved hypothetical protein
— Both
C4B63_7g145
conserved hypothetical protein
— Both
C4B63_14g170
19S proteasome regulatory subunit
— OG6
C4B63_10g511 ⚠
26S proteasome regulatory non-ATPase subunit
— Both
C4B63_7g263
ribosomal RNA processing protein 6
— Both
C4B63_20g172
chaperonin alpha subunit
— OG6
C4B63_4g92
19S proteasome non-atpase subunit 8
— Both
C4B63_23g31
26S protease regulatory subunit
— OG6
C4B63_78g44
proteasome regulatory non-ATPase subunit
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.